Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages

by Ann-Lii Cheng, Da-Liang Ou, Chia-Wei Chen, Chia-Lang Hsu, Chih-Hung Chung, Zi-Rui Feng, Bin-Shyun Lee, Muh-Hwa Yang, Chiun Hsu
Published 2021-03-01

Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC)

by Mark Awad, Mizuki Nishino, Mariano Severgnini, Biagio Ricciuti, Joao V Alessi, Gonzalo Recondo, Marissa Lawrence, Greg Jones, Tim Forshew, Christine Lydon, Michael Cheng
Published 2021-03-01

Circulating cytokines associated with clinical response to systemic therapy in metastatic renal cell carcinoma

by Marcin Kortylewski, Nazli Dizman, Nicholas Salgia, Marice Alcantara, Luis Meza, Sabrina Salgia, Jasnoor Malhotra, Paulo Bergerot, Nora Ruel, Ewa Karczewska
Published 2021-03-01

Clinical and immunologic impact of short-course enzalutamide alone and with immunotherapy in non-metastatic castration sensitive prostate cancer

by Harpreet Singh, Seth Steinberg, Lisa Cordes, Helen Owens, Amy Hankin, Anna Couvillon, Marc R Theoret, Munjid Al-Harthy, Inger I Rosner, Philip M Arlen, Moniquea Williams, Sarah E Lochrin, Cindy H Chau, William Douglas Figg, William Dahut
Published 2021-03-01

LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types

by Ramy Sedhom, Santosh Gupta, Yuan Wu, Jason Zhu, Daniele Marin, Michael R Harrison, Landon C Brown, Matthew D Tucker, Eric B Schwartz, Chester Kao, Matthew K Labriola, Rajan T Gupta, Daniel J George, Emmanuel S Antonarakis, Andrew J Armstrong
Published 2021-03-01

T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A+CD141+ cDC1 and CD14+ antigen-presenting cell recruitment

by Tanja D de Gruijl, M Petrousjka van den Tol, Bas D Koster, Rik J Scheper, Barbara G Molenkamp, Alfons JM van den Eertwegh, Mari FCM van den Hout, Berbel JR Sluijter, Paul AM van Leeuwen, Marta López González, Annelies W Turksma, Saskia Vosslamber, Ekaterina J Jordanova
Published 2021-03-01

Primary results from TAIL: a global single-arm safety study of atezolizumab monotherapy in a diverse population of patients with previously treated advanced non-small cell lung can...

by Jinming Yu, Andrés Cardona, Andrea Ardizzoni, Delvys Rodriguez-Abreu, Sergio Azevedo, Belen Rubio-Viqueira, Jorge Alatorre-Alexander, Hans J M Smit, Konstantinos Syrigos, Kerstin Trunzer, Hina Patel, Jonathan Tolson, Pablo D Perez-Moreno
Published 2021-03-01

Prediction of severe immune-related adverse events requiring hospital admission in patients on immune checkpoint inhibitors: study of a population level insurance claims database f...

by Kun-Hsing Yu, Shannon Wongvibulsin, William Murphy, Leyre Zubiri, Vartan Pahalyants, Mark Kalinich, Feicheng Wang, Vivek Naranbhai, Alexander Gusev, Kerry L Reynolds, Chenyue Lu, Shawn G Kwatra, Yevgeniy R Semenov
Published 2021-03-01

Tumor DNA methylation profiles correlate with response to anti-PD-1 immune checkpoint inhibitor monotherapy in sarcoma patients

by Matthias Preusser, Leonhard Müllauer, Anna S Berghoff, Sebastian Bauer, Gerwin Heller, Thomas Brodowicz, Wolfgang Lamm, Katharina Feldmann, Angelika M Starzer, Rainer Hamacher, Erwin Tomasich, Teresa Hatziioannou, Stefan Traint, Iris M Noebauer-Huhmann, Julia Furtner, Gabriele Amann, Hans-Ulrich Schildhaus
Published 2021-03-01

Complete metabolic response in patients with advanced non-small cell lung cancer with prolonged response to immune checkpoint inhibitor therapy

by Viktor Grünwald, Justin Ferdinandus, Martin Metzenmacher, Lukas Kessler, Lale Umutlu, Clemens Aigner, Wolfgang Peter Fendler, Ken Herrmann, Martin Faehling, Daniel Christian Christoph, Karl-Otto Kambartel, Wilfried Ernst Erich Eberhardt
Published 2021-03-01

Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breas...

by Simon Gebremeskel, Adam Nelson, Brynn Walker, Tora Oliphant, Lynnea Lobert, Douglas Mahoney, Brent Johnston
Published 2021-03-01

Anti-GD2 antibody dinutuximab inhibits triple-negative breast tumor growth by targeting GD2+ breast cancer stem-like cells

by Debasish Tripathy, Khoa Nguyen, Stanley Ly, Vivek Anand, Fouad El-Dana, Yiming Cai, Shirong Cai, Helen Piwnica-Worms, Aysegul A Sahin, Michael Andreeff, Venkata Lokesh Battula
Published 2021-03-01

Host response to immune checkpoint inhibitors contributes to tumor aggressiveness

by Ziv Raviv, Yuval Shaked, Michal Harel, Eyal Jacob, Irina Khononov, Ella Fremder, Nili Dahan, Boris Krastev
Published 2021-03-01

Safety and activity of the TGFβ receptor I kinase inhibitor galunisertib plus the anti-PD-L1 antibody durvalumab in metastatic pancreatic cancer

by Antoine Hollebecque, Rocio Garcia-Carbonero, Do-Youn Oh, Emiliano Calvo, Davide Melisi, Teresa Macarulla, Valeria Merz, Erkut Borazanci, Anna Varghese, Camilla Zecchetto, Yumin Zhao, Ivelina Gueorguieva, Michael Man, Shawn T Estrem, Karim A Benhadji, Emin Avsar, Susan C Guba
Published 2021-03-01

Narrowband ultraviolet B therapy for refractory immune-related lichenoid dermatitis on PD-1 therapy: a case report

by Wilson H Miller, Khashayar Esfahani, Meagan-Helen Henderson Berg, Hanieh Zargham, Robin Billick, Kevin Pehr, Margaret Redpath, Osama Roshdy
Published 2021-03-01

Higher postoperative plasma EV PD-L1 predicts poor survival in patients with gastric cancer

by Guoliang Wang, Feng Li, Gaopeng Li, Ting Liu, Fenqing Chi, Yuqi Jia, Quankai Mu, Keru Qin, Xiaoxia Zhu, Baixue Xu, Guangen Feng, Yuhu Niu, Tao Gong, Hongwei Zhang, Xiushan Dong, Jinfeng Ma, Zefeng Gao, Kai Tao, Baofeng Yu
Published 2021-03-01

Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer

by Yuan Li, Jian Zheng, Zhizhong Pan, Guochen Liu, Wu Jiang, Pei-Rong Ding, Zexian Liu, Qiaoqi Sui, Dingxin Liu, Jinghua Tang, Lingheng Kong, Kai Han, Leen Liao, Qingjian Ou, Binyi Xiao, Yihong Ling, Jiewei Chen, Zhixiang Zuo
Published 2021-03-01