Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors

by Andrew L Mammen, Jarushka Naidoo, Divyanshu Dubey, Michael Dougan, Teilo H Schaller, Meghan J Mooradian, Douglas B Johnson, Jorg Dietrich, Leyre Zubiri, Tomas G Neilan, Bianca D Santomasso, Ryan J Sullivan, Kerry L Reynolds, Allison Betof Warner, Justine V Cohen, Nancy Wang, Jenny Linnoila, Jeffrey M Gelfand, Anthony A Amato, Stacey L Clardy, David A Reardon, William C Louv, Amanda C Guidon, Leeann B Burton, Bart K Chwalisz, James Hillis, Priscilla K Brastianos, Tracey A Cho, Christopher T Doughty, Jeffrey T Guptill, Vern C Juel, Robert Kadish, Noah Kolb, Nicole R LeBoeuf, Maria Martinez-Lage, Krista M Rubin, Karin Woodman
Published 2021-07-01

It’s not ‘just a tube of blood’: principles of protocol development, sample collection, staffing and budget considerations for blood-based biomarkers in immunotherapy studies

by Michael D Green, Lili Zhao, Dean E Brenner, Cindy Y Jiang, Zeqi Niu, Shelby Raupp, Brittany Pannecouk, Sunitha Nagrath, Nithya Ramnath
Published 2021-07-01

Clinical efficacy of T-cell therapy after short-term BRAF-inhibitor priming in patients with checkpoint inhibitor-resistant metastatic melanoma

by Marco Donia, Rikke Andersen, Troels Holz Borch, Per Kongsted, Özcan Met, Julie Westerlin Kjeldsen, Morten Nielsen, Magnus Pedersen, Martin Lauss, Göran Jönsson, Inge Marie Svane, Katja Harbst, Aynal Haque Rana, Evelina Martinenaite, Anders Handrup Kverneland, Lisbet Rosenkrantz Hölmich, Helle Hendel
Published 2021-07-01

Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy

by Guangsheng Pei, Zhongming Zhao, Divya Ravirala, Brandon Mistretta, Preethi H Gunaratne, Xiaoliu Zhang
Published 2021-07-01

Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity

by Ling Li, Jing Jin, Jun Ye, Tong Sun, Zhaohui Wang, Hongliang Wang, Yuling Liu, Ming Ji, Yue Gao, Yanfang Yang, Baolian Wang, Xiaoyan Xu, Hengfeng Liao, Chunfang Lian, Yaqi Xu, Renjie Li, Lili Gao, Xiaoguang Chen
Published 2021-07-01

Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies

by Christian Klein, Marina Bacac, Pablo Umana, Gabrielle Leclercq, Hélène Haegel, Anneliese Schneider, Anna Maria Giusti, Estelle Marrer-Berger, Christophe Boetsch, Antje-Christine Walz, Vesna Pulko, Johannes Sam, John Challier, Cristiano Ferlini, Alex Odermatt
Published 2021-07-01

p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition

by Rienk Offringa, Daniel Baumann, Jennifer Drebant, Tanja Hägele, Luisa Burger, Clara Serger, Claudia Lauenstein, Przemyslaw Dudys, Gerrit Erdmann
Published 2021-07-01

First-in-human DR5 PET reveals insufficient DR5 expression in patients with gastrointestinal cancer

by Feng Wang, Yan Zhang, Hua Zhu, Jin Ding, Nan Li, Tong Zhou, Jun Zhao, Zhi Yang, Yingjie Li, Xinyu Wang, Yunfeng Yao, Shujing Wang, Lixin Ding, Aiwen Wu
Published 2021-07-01

Tumor rejection in Cblb−/− mice depends on IL-9 and Th9 cells

by Jenny Landsberg, Dominik Wolf, Peter Krawitz, Gottfried Baier, Peter Brossart, Oliver Schanz, Isabelle Cornez, Sowmya Parampalli Yajnanarayana, Friederike Sophie David, Sebastian Peer, Thomas Gruber, Annkristin Heine
Published 2021-07-01

CX-072 (pacmilimab), a Probody® PD-L1 inhibitor, in advanced or recurrent solid tumors (PROCLAIM-CX-072): an open-label dose-finding and first-in-human study

by Hendrik-Tobias Arkenau, Marta Gil-Martin, Fiona Thistlethwaite, Karen A. Autio, Patrick A. Ott, Johanna Bendell, Patricia LoRusso, Valentina Boni, Alexander Spira, Javier Garcia-Corbacho, Mark Stroh, Elisabeth G.E. De Vries, Ferry A.L.M. Eskens, Nataliya Uboha, Manreet Randhawa, Greg Durm, Alison L. Hannah
Published 2021-07-01

Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead

by Daniel Abate-Daga, Christine H Chung, Kedar Kirtane, Hany Elmariah
Published 2021-07-01

DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma

by Bastian Schilling, Sascha Tierling, Jörn Walter, Katharina Filipski, Michael Scherer, Kim N. Zeiner, Andreas Bucher, Johannes Kleemann, Philipp Jurmeister, Tabea I. Hartung, Markus Meissner, Karl H. Plate, Tim R. Fenton, Pia S. Zeiner, Patrick N. Harter
Published 2021-07-01

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies

by Shohei Koyama, Hiroyoshi Nishikawa
Published 2021-07-01

ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer

by Lan Shao, Bin Huang, Xinyao Zhang, Zongren Wang, Xueling Zhang, Wuguo Li, Qiao Su, Zhaoyang Huang, Haiqi Chen, Chengqiang Mo, Wei Ou, Junxing Chen, Guangyin Zhao, Lingwu Chen
Published 2021-07-01

CX-072 (pacmilimab), a Probody PD-L1 inhibitor, in combination with ipilimumab in patients with advanced solid tumors (PROCLAIM-CX-072): a first-in-human, dose-finding study

by Omid Hamid, Fiona Thistlethwaite, Johanna Bendell, Ruth Plummer, Patrick A Ott, Rachel E Sanborn, Karen A Autio, Valentina Boni, Elisabeth GE de Vries, Javier Garcia-Corbacho, Daniel C Cho, Mark Stroh, Lawrence Lu
Published 2021-07-01

WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

by Jennifer L Waller, Chunwan Lu, Kebin Liu, John D Klement, Dafeng Yang, Zhuoqi Liu, Alyssa D Merting, Dakota Poschel, Thomas Albers, Huidong Shi
Published 2021-07-01

Durable responses in patients with genitourinary cancers following immune checkpoint therapy rechallenge after moderate-to-severe immune-related adverse events

by Jennifer Wang, Jianjun Gao, Pavlos Msaouel, Padmanee Sharma, Nizar Tannir, Sumit K Subudhi, Eric Jonasch, Amishi Shah, Matthew T Campbell, Bilal A Siddiqui, Jinesh S Gheeya, Rohit Goswamy, Tharakeswara K Bathala, Devaki Shilpa Surasi, Sangeeta Goswami, Amado J Zurita, Paul G Corn, Ana M Aparicio, Arlene O Siefker-Radtke
Published 2021-07-01

Antiviral antibody responses to systemic administration of an oncolytic RNA virus: the impact of standard concomitant anticancer chemotherapies

by Kevin Harrington, Hardev Pandha, Alan Melcher, David Mansfield, Johann De Bono, Victoria Roulstone, Christine White, James Spicer, Richard Vile, Sophia N Karagiannis, Robert J Harris, Katie Twigger
Published 2021-07-01

Modified Glasgow Prognostic Score associated with survival in metastatic renal cell carcinoma treated with immune checkpoint inhibitors

by Yuan Liu, Haydn Kissick, Viraj A Master, Mehmet Asim Bilen, Dylan Martini, Lauren Yantorni, Sarah Caulfield, Bassel Nazha, Omer Kucuk, Deepak Ravindranathan, Kenneth Ogan, Jacqueline T Brown, Julie M Shabto, Emilie Elise Hitron, Greta Anne Russler, Shreyas Subhash Joshi, Bradley C Carthon, Wayne B Harris
Published 2021-07-01

Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/...

by Lei Wang, Mohammed Milhem, Sudershan Bhatia, Varun Monga, Benjamin J Miller, Munir Tanas, Sarag Boukhar, Bryan Allen, Carryn Anderson, Laura Stephens, Stacey Hartwig, Steven Varga, Jon Houtman, Weizhou Zhang, Omar Jaber, Jon Thomason, David Kuehn, Maheen Rajput, Catherine Metz, K.D. Zamba, Sarah Mott, Chinemerem Abanonu
Published 2021-07-01