Design, synthesis and biological evaluation of a new thieno[2,3-d]pyrimidine-based urea derivative with potential antitumor activity against tamoxifen sensitive and resistant breas...

by Marwa Sharaky, Marwa Kamel, Marwa A. Aziz, Mervat Omran, Monira M. Rageh, Khaled A. M. Abouzid, Samia A. Shouman
Published 2020-01-01

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

by Wenjin Li, Joren Guillaume, Younis Baqi, Isabell Wachsmann, Volkmar Gieselmann, Serge Van Calenbergh, Christa E. Müller
Published 2020-01-01

Toxicity evaluation of sulfamides and coumarins that efficiently inhibit human carbonic anhydrases

by Ashok Aspatwar, Emanuela Berrino, Silvia Bua, Fabrizio Carta, Clemente Capasso, Seppo Parkkila, Claudiu T. Supuran
Published 2020-01-01

Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors

by Begüm Nurpelin Sağlık, Derya Osmaniye, Ulviye Acar Çevik, Serkan Levent, Betül Kaya Çavuşoğlu, Özlem Atlı Eklioğlu, Yusuf Özkay, Ali Savaş Koparal, Zafer Asım Kaplancıklı
Published 2020-01-01

Inhibitory activity against carbonic anhydrase IX and XII as a candidate selection criterion in the development of new anticancer agents

by Mikhail Krasavin, Stanislav Kalinin, Tatiana Sharonova, Claudiu T. Supuran
Published 2020-01-01

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

by Tommaso Felicetti, Gianmarco Mangiaterra, Rolando Cannalire, Nicholas Cedraro, Donatella Pietrella, Andrea Astolfi, Serena Massari, Oriana Tabarrini, Giuseppe Manfroni, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini
Published 2020-01-01

Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control

by Xin Wang, Kaiyuan Deng, Cheng Wang, Yao Li, Tianqi Wang, Zhi Huang, Yakun Ma, Peiqing Sun, Yi Shi, Shengyong Yang, Yan Fan, Rong Xiang
Published 2020-01-01

Synthesis and biological activity of 2-cyanoacrylamide derivatives tethered to imidazopyridine as TAK1 inhibitors

by Seok Jong Kang, Jung Wuk Lee, Jiho Song, Jiwon Park, Jaeyul Choi, Kwee Hyun Suh, Kyung Hoon Min
Published 2020-01-01

Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

by Fabrice Pagniez, Nicolas Lebouvier, Young Min Na, Isabelle Ourliac-Garnier, Carine Picot, Marc Le Borgne, Patrice Le Pape
Published 2020-01-01

Inhibition of African swine fever virus protease by myricetin and myricitrin

by Seri Jo, Suwon Kim, Dong Hae Shin, Mi-Sun Kim
Published 2020-01-01

Inhibition survey with phenolic compounds against the δ- and η-class carbonic anhydrases from the marine diatom thalassiosira weissflogii and protozoan Plasmodium falciparum

by Siham A. Alissa, Hanan A. Alghulikah, Zeid A. ALOthman, Sameh M. Osman, Sonia Del Prete, Clemente Capasso, Alessio Nocentini, Claudiu T. Supuran
Published 2020-01-01

Inhibition mechanism of naphthylphenylamine derivatives acting on the CDC25B dual phosphatase and analysis of the molecular processes involved in the high cytotoxicity exerted by o...

by Federica Aliotta, Rosarita Nasso, Rosario Rullo, Alessandro Arcucci, Angelica Avagliano, Martina Simonetti, Gennaro Sanità, Mariorosario Masullo, Antonio Lavecchia, Maria Rosaria Ruocco, Emmanuele De Vendittis
Published 2020-01-01

Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists

by Aurélie Hurtevent, Morgan Le Naour, Veronique Leclerc, Pascal Carato, Patricia Melnyk, Nathalie Hennuyer, Bart Staels, Monique Beucher-Gaudin, Daniel-Henri Caignard, Catherine Dacquet, Nicolas Lebegue
Published 2020-01-01

Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy

by Yuyan Lin, Tao Zhou, Renren Bai, Yuanyuan Xie
Published 2020-01-01

Screening of ninety herbal products of commercial interest as potential ingredients for phytocosmetics

by Mariacaterina Lianza, Manuela Mandrone, Ilaria Chiocchio, Paola Tomasi, Lorenzo Marincich, Ferruccio Poli
Published 2020-01-01

Design, synthesis and α-glucosidase inhibition study of novel embelin derivatives

by Xiaole Chen, Min Gao, Rongchao Jian, Weiqian David Hong, Xiaowen Tang, Yuling Li, Denggao Zhao, Kun Zhang, Wenhua Chen, Xi Zheng, Zhaojun Sheng, Panpan Wu
Published 2020-01-01

Antiproliferative chromone derivatives induce K562 cell death through endogenous and exogenous pathways

by Runwei Jiao, Fanxing Xu, Xiaofang Huang, Haonan Li, Weiwei Liu, Hao Cao, Linghe Zang, Zhanlin Li, Huiming Hua, Dahong Li
Published 2020-01-01

Biochemical and structural characterisation of a protozoan beta-carbonic anhydrase from Trichomonas vaginalis

by Linda J. Urbański, Anna Di Fiore, Latifeh Azizi, Vesa P. Hytönen, Marianne Kuuslahti, Martina Buonanno, Simona M. Monti, Andrea Angeli, Reza Zolfaghari Emameh, Claudiu T. Supuran, Giuseppina De Simone, Seppo Parkkila
Published 2020-01-01

Design, synthesis, HER2 inhibition and anticancer evaluation of new substituted 1,5-dihydro-4,1-benzoxazepines

by Olga Cruz-López, Matilde Ner, Francho Nerín-Fonz, Yaiza Jiménez-Martínez, David Araripe, Juan A. Marchal, Houria Boulaiz, Hugo Gutiérrez-de-Terán, Joaquín M. Campos, Ana Conejo-García
Published 2021-01-01

Carbonic anhydrase IX as a novel candidate in liquid biopsy

by Ozen Ozensoy Guler, Claudiu. T. Supuran, Clemente Capasso
Published 2020-01-01