A study of Rose Bengal against a 2-keto-3-deoxy-d-manno-octulosonate cytidylyltransferase as an antibiotic candidate

by Suwon Kim, Seri Jo, Mi-Sun Kim, Dong Hae Shin
Published 2020-01-01

Multidirectional in vitro and in cellulo studies as a tool for identification of multi-target-directed ligands aiming at symptoms and causes of Alzheimer’s disease

by Natalia Szałaj, Justyna Godyń, Jakub Jończyk, Anna Pasieka, Dawid Panek, Tomasz Wichur, Krzysztof Więckowski, Paula Zaręba, Marek Bajda, Anja Pislar, Barbara Malawska, Raimon Sabate, Anna Więckowska
Published 2020-01-01

Design, synthesis and biological evaluation of edaravone derivatives bearing the N-benzyl pyridinium moiety as multifunctional anti-Alzheimer’s agents

by Luke S. Zondagh, Sarel F. Malan, Jacques Joubert
Published 2020-01-01

Design, synthesis, and evaluation of 1, 4-benzodioxan-substituted chalcones as selective and reversible inhibitors of human monoamine oxidase B

by Zhuo Kong, Demeng Sun, Yanmei Jiang, Yun Hu
Published 2020-01-01

Design, synthesis and anticancer activity of naphthoquinone derivatives

by Xiao-bao Shen, Yang Wang, Xuan-zhen Han, Liang-quan Sheng, Fu-fang Wu, Xinhua Liu
Published 2020-01-01

Discovery of 3-alkyl-5-aryl-1-pyrimidyl-1H-pyrazole derivatives as a novel selective inhibitor scaffold of JNK3

by Youri Oh, Miyoung Jang, Hyunwook Cho, Songyi Yang, Daseul Im, Hyungwoo Moon, Jung-Mi Hah
Published 2020-01-01

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison

by Ulviye Acar Çevik, Begüm Nurpelin Sağlık, Derya Osmaniye, Serkan Levent, Betül Kaya Çavuşoğlu, Abdullah Burak Karaduman, Özlem Atlı Eklioğlu, Yusuf Özkay, Zafer Asım Kaplancıklı
Published 2020-01-01

Synthesis and human carbonic anhydrase I, II, VA, and XII inhibition with novel amino acid–sulphonamide conjugates

by Hasan Küçükbay, Nesrin Buğday, F. Zehra Küçükbay, Andrea Ageli, Gianluca Bartolucci, Claudiu T. Supuran
Published 2020-01-01

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson’s disease

by Serena Vittorio, Ilenia Adornato, Rosaria Gitto, Samuel Peña-Díaz, Salvador Ventura, Laura De Luca
Published 2020-01-01

A nanobody-derived mimotope against VEGF inhibits cancer angiogenesis

by Elmira Karami, Jean-Marc Sabatier, Mahdi Behdani, Shiva Irani, Fatemeh Kazemi-Lomedasht
Published 2020-01-01

Quetiapine and novel PDE10A inhibitors potentiate the anti-BuChE activity of donepezil

by Joanna Sikora, Maria Podsiedlik, Tadeusz Pietras, Marcin Kosmalski, Mikołaj Matłoka, Rafał Moszczyński-Petkowski, Maciej Wieczorek, Magdalena Markowicz-Piasecka
Published 2020-01-01

Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors

by Thomas S. Corrigan, Leilani M. Lotti Diaz, Sarah E. Border, Steven C. Ratigan, Kayla Q. Kasper, Daniel Sojka, Pavla Fajtova, Conor R. Caffrey, Guy S. Salvesen, Craig A. McElroy, Christopher M. Hadad, Özlem Doğan Ekici
Published 2020-01-01

Structure activity relationship studies on Amb639752: toward the identification of a common pharmacophoric structure for DGKα inhibitors

by Suresh Velnati, Alberto Massarotti, Annamaria Antona, Maria Talmon, Luigia Grazia Fresu, Alessandra Silvia Galetto, Daniela Capello, Alessandra Bertoni, Valentina Mercalli, Andrea Graziani, Gian Cesare Tron, Gianluca Baldanzi
Published 2020-01-01

Development of a cheminformatics platform for selectivity analyses of carbonic anhydrase inhibitors

by Giulio Poli, Salvatore Galati, Adriano Martinelli, Claudiu T. Supuran, Tiziano Tuccinardi
Published 2020-01-01

Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii

by Sonia Del Prete, Alessio Nocentini, Claudiu T. Supuran, Clemente Capasso
Published 2020-01-01

Novel piperidine derivatives as colchicine binding site inhibitors induce apoptosis and inhibit epithelial-mesenchymal transition against prostate cancer PC3 cells

by Dong-Jun Fu, Si-Meng Liu, Jia-Jia Yang, Jun Li
Published 2020-01-01

S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors

by Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Nawaf A. AlSaif, Mohammed M. Alanazi, Manal A. El-Gendy, Hany E. A. Ahmed, Claudiu T. Supuran
Published 2020-01-01

CO2 permeability of the rat erythrocyte membrane and its inhibition

by Samer Al-Samir, Maximilian Prill, Claudiu T. Supuran, Gerolf Gros, Volker Endeward
Published 2021-01-01

Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3

by Paula Martínez de Iturrate, Victor Sebastián-Pérez, Montserrat Nácher-Vázquez, Catherine S. Tremper, Despina Smirlis, Julio Martín, Ana Martínez, Nuria E. Campillo, Luis Rivas, Carmen Gil
Published 2020-01-01

Enzyme-assisted modification of flavonoids from Matricaria chamomilla: antioxidant activity and inhibitory effect on digestive enzymes

by Elida Paula Dini de Franco, Fabiano Jares Contesini, Bianca Lima da Silva, Anna Maria Alves de Piloto Fernandes, Camila Wielewski Leme, João Pedro Gonçalves Cirino, Paula Renata Bueno Campos, Patrícia de Oliveira Carvalho
Published 2020-01-01