An immune-based risk-stratification system for predicting prognosis in pulmonary sarcomatoid carcinoma (PSC)

by Haoyue Guo, Binglei Li, Li Diao, Hao Wang, Peixin Chen, Minlin Jiang, Lishu Zhao, Yayi He, Caicun Zhou
Published 2021-01-01

Integrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer

by Yuzhen Gao, Hao Wang, Huiming Li, Xinxin Ye, Yan Xia, Shijin Yuan, Jie Lu, Xinyou Xie, Liangjing Wang, Jun Zhang
Published 2021-01-01

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

by Adrien Joseph, Juncheng Pan, Judith Michels, Guido Kroemer, Maria Castedo
Published 2021-01-01

Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells

by Dandan Fan, Qi Yue, Jian Chen, Cong Wang, Ruilin Yu, Ziyi Jin, Shujie Yin, Qinyue Wang, Luo Chen, Xueling Liao, Chengyuan Peng, Jianpin Zhang, Zhonglian Cao, Ying Mao, Ruimin Huang, Liang Chen, Cong Li
Published 2021-01-01

Impact of cancer cachexia on the therapeutic outcome of combined chemoimmunotherapy in patients with non-small cell lung cancer: a retrospective study

by Kenji Morimoto, Junji Uchino, Takashi Yokoi, Takashi Kijima, Yasuhiro Goto, Akira Nakao, Makoto Hibino, Takayuki Takeda, Hiroyuki Yamaguchi, Chieko Takumi, Masafumi Takeshita, Yusuke Chihara, Takahiro Yamada, Osamu Hiranuma, Yoshie Morimoto, Masahiro Iwasaku, Yoshiko Kaneko, Tadaaki Yamada, Koichi Takayama
Published 2021-01-01

Tertiary lymphoid structure signatures are associated with survival and immunotherapy response in muscle-invasive bladder cancer

by Lin Zhou, Bin Xu, Yushan Liu, Zhong Wang
Published 2021-01-01

Sustained localized delivery of immunotherapy to lymph nodes reverses immunosuppression and increases long-term survival in murine glioblastoma

by John Choi, Ayush Pant, Ravi Medikonda, Young-Hoon Kim, Denis Routkevitch, Laura Saleh, Luqing Tong, Hok Yee Chan, Jessie Nedrow, Christopher Jackson, Christina Jackson, Michael Lim
Published 2021-01-01

Evaluation of switch-mediated costimulation in trans on universal CAR-T cells (UniCAR) targeting CD123-positive AML

by Jan-Erik Meyer, Simon Loff, Josephine Dietrich, Johannes Spehr, Gabriel Jurado Jiménez, Malte von Bonin, Gerhard Ehninger, Marc Cartellieri, Armin Ehninger
Published 2021-01-01

Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers

by Kwang-Yu Chang, Nai-Jung Chiang, Shang-Yin Wu, Chia-Jui Yen, Shang-Hung Chen, Yu-Min Yeh, Chien-Feng Li, Xiaoxing Feng, Katherine Wu, Amanda Johnston, John S. Bomalaski, Bor-Wen Wu, Jianjun Gao, Sumit K. Subudhi, Ahmed O. Kaseb, Jorge M. Blando, Shalini S. Yadav, Peter W. Szlosarek, Li-Tzong Chen
Published 2021-01-01

Have CD19-directed immunotherapy and haploidentical hematopoietic cell transplantation transformed pediatric B-cell acute lymphoblastic leukemia into a chronic disease?

by Holly Pariury, Laurel Truscott, Emmanuel Katsanis
Published 2021-01-01

Cldn-7 deficiency promotes experimental colitis and associated carcinogenesis by regulating intestinal epithelial integrity

by Kun Wang, Yuhan Ding, Chang Xu, Mengdi Hao, Huimin Li, Lei Ding
Published 2021-01-01

Comprehensive analyses reveal TKI-induced remodeling of the tumor immune microenvironment in EGFR/ALK-positive non-small-cell lung cancer

by Yisheng Fang, Yuanyuan Wang, Dongqiang Zeng, Shimeng Zhi, Tingting Shu, Na Huang, Siting Zheng, Jianhua Wu, Yantan Liu, Genjie Huang, Yichen Xue, Jianping Bin, Yulin Liao, Min Shi, Wangjun Liao
Published 2021-01-01

In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced...

by Sarah Bonte, Stijn de Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz de Cock, Karin Weening, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
Published 2021-01-01

Expression of the immune checkpoint receptors PD-1, LAG3, and TIM3 in the immune context of stage II and III gastric cancer by using single and chromogenic multiplex immunohistoche...

by Yujun Park, An Na Seo, Jiwon Koh, Soo Kyoung Nam, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Hye Seung Lee
Published 2021-01-01

Hypoxia increases melanoma-associated fibroblasts immunosuppressive potential and inhibitory effect on T cell-mediated cytotoxicity

by Linda Ziani, Stéphanie Buart, Salem Chouaib, Jerome Thiery
Published 2021-01-01

Autoantibody profiling of alveolar rhabdomyosarcoma patients unveils tumor-associated antigens with diagnostic and prognostic significance

by Elena Poli, Manuela Cattelan, Ilaria Zanetti, Angela Scagnellato, Giuseppe Giordano, Angelica Zin, Gianni Bisogno, Paolo Bonvini
Published 2021-01-01

DGKζ exerts greater control than DGKα over CD8+ T cell activity and tumor inhibition

by Junchen Gu, Cindy Wang, Carolyn Cao, Jinwen Huang, Sandra Holzhauer, Heshani Desilva, Erin M. Wesley, Douglas B. Evans, Joseph Benci, Michael Wichroski, Susan Wee, Matthew J. Riese
Published 2021-01-01

CanImmunother: a manually curated database for identification of cancer immunotherapies associating with biomarkers, targets, and clinical effects

by Wenliang Zhang, Binghui Zeng, Huancai Lin, Wen Guan, Jing Mo, Song Wu, Yanjie Wei, Qianshen Zhang, Dongsheng Yu, Weizhong Li, Godfrey Chi-Fung Chan
Published 2021-01-01

A therapeutic DNA vaccine and gemcitabine act synergistically to eradicate HPV-associated tumors in a preclinical model

by Jamile Ramos da Silva, Ana Carolina Ramos Moreno, Natiely Silva Sales, Mariângela de Oliveira Silva, Luana R. M. M. Aps, Bruna F.M.M. Porchia, Karine Bitencourt Rodrigues, Natália Cestari Moreno, Aléxia Adrianne Venceslau-Carvalho, Carlos Frederico M. Menck, Mariana de Oliveira Diniz, Luís Carlos de Souza Ferreira
Published 2021-01-01

Alternol triggers immunogenic cell death via reactive oxygen species generation

by Changlin Li, Ying Zhang, Siyuan Yan, Guoan Zhang, Wei Wei, Zhi Qi, Benyi Li
Published 2021-01-01