An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering

by Daniel A Keedy, Zachary B Hill, Justin T Biel, Emily Kang, T Justin Rettenmaier, José Brandão-Neto, Nicholas M Pearce, Frank von Delft, James A Wells, James S Fraser
Published 2018-06-01

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

by Emily F Ruff, Joseph M Muretta, Andrew R Thompson, Eric W Lake, Soreen Cyphers, Steven K Albanese, Sonya M Hanson, Julie M Behr, David D Thomas, John D Chodera, Nicholas M Levinson
Published 2018-02-01

Signaling within Allosteric Machines: Signal Transmission Pathways Inside G Protein-Coupled Receptors

by Damian Bartuzi, Agnieszka A. Kaczor, Dariusz Matosiuk
Published 2017-07-01

Deconstruction of the Ras switching cycle through saturation mutagenesis

by Pradeep Bandaru, Neel H Shah, Moitrayee Bhattacharyya, John P Barton, Yasushi Kondo, Joshua C Cofsky, Christine L Gee, Arup K Chakraborty, Tanja Kortemme, Rama Ranganathan, John Kuriyan
Published 2017-07-01

Unraveling of a Strongly Correlated Dynamical Network of Residues Controlling the Permeation of Potassium in KcsA Ion Channel

by Salvatore M. Cosseddu, Eunju Julia Choe, Igor A. Khovanov
Published 2021-01-01

The Structural Dynamics of Human Immunodeficiency Virus Type I Reverse Transcriptase

by Seckler, James Malcolm
Published 2011

Allosteric activation of SENP1 by SUMO1 β-grasp domain involves a dock-and-coalesce mechanism

by Jingjing Guo, Huan-Xiang Zhou
Published 2016-08-01

Large scale analysis of protein conformational transitions from aqueous to non-aqueous media

by Ana Julia Velez Rueda, Alexander Miguel Monzon, Sebastián M. Ardanaz, Luis E. Iglesias, Gustavo Parisi
Published 2018-01-01

Effects of Pressure and Temperature on the Atomic Fluctuations of Dihydrofolate Reductase from a Psychropiezophile and a Mesophile

by Qi Huang, Jocelyn M. Rodgers, Russell J. Hemley, Toshiko Ichiye
Published 2019-03-01

Lactose Binding Induces Opposing Dynamics Changes in Human Galectins Revealed by NMR-Based Hydrogen–Deuterium Exchange

by Chih-Ta Henry Chien, Meng-Ru Ho, Chung-Hung Lin, Shang-Te Danny Hsu
Published 2017-08-01

An In Vivo Study of the Function and Dynamics of Stereociliary Proteins

by Hwang, Philsang
Published 2015

Comparative investigations of H-transfer in dihydrofolate reductases from different families

by Yahashiri, Atsushi
Published 2010

Local frustration determines loop opening during the catalytic cycle of an oxidoreductase

by Lukas S Stelzl, Despoina AI Mavridou, Emmanuel Saridakis, Diego Gonzalez, Andrew J Baldwin, Stuart J Ferguson, Mark SP Sansom, Christina Redfield
Published 2020-06-01

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

by Daniel A Keedy, Lillian R Kenner, Matthew Warkentin, Rahel A Woldeyes, Jesse B Hopkins, Michael C Thompson, Aaron S Brewster, Andrew H Van Benschoten, Elizabeth L Baxter, Monarin Uervirojnangkoorn, Scott E McPhillips, Jinhu Song, Roberto Alonso-Mori, James M Holton, William I Weis, Axel T Brunger, S Michael Soltis, Henrik Lemke, Ana Gonzalez, Nicholas K Sauter, Aina E Cohen, Henry van den Bedem, Robert E Thorne, James S Fraser
Published 2015-09-01

Assessment of transferable forcefields for protein simulations attests improved description of disordered states and secondary structure propensities, and hints at multi-protein sy...

by Luciano A. Abriata, Matteo Dal Peraro
Published 2021-01-01

Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

by Benjamin P. Cossins, Alastair D. G. Lawson
Published 2015-09-01

X-ray lasers for structure and dynamics in biology

by John C. H. Spence
Published 2018-05-01

Calorimetric and Dielectric Studies of Self-assembled Bio-molecules in an Aqueous Environment

by Kashuri, Klaida
Published 2014

Dynamics and Mechanism of Short-Range Electron Transfer Reactions in Flavoproteins.

by Kundu, Mainak
Published 2019

Entropy-Based Strategies for Rapid Pre-Processing and Classification of Time Series Data from Single-Molecule Force Experiments

by Denis Horvath, Gabriel Žoldák
Published 2020-06-01