Antibody Fragments Defining Biologically Relevant Conformations of Target Proteins

by Alastair D. G. Lawson
Published 2014-12-01

Opportunities for Conformation-Selective Antibodies in Amyloid-Related Diseases

by Marta Westwood, Alastair D. G. Lawson
Published 2015-07-01

Small Molecule Targeting of Protein–Protein Interactions through Allosteric Modulation of Dynamics

by Benjamin P. Cossins, Alastair D. G. Lawson
Published 2015-09-01

Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules

by Alastair D. G. Lawson, Malcolm MacCoss, Dominique L. Baeten, Alex Macpherson, Jiye Shi, Alistair J. Henry
Published 2021-05-01

Bimekizumab, a Novel Humanized IgG1 Antibody That Neutralizes Both IL-17A and IL-17F

by Ralph Adams, Asher Maroof, Terry Baker, Alastair D. G. Lawson, Ruth Oliver, Ross Paveley, Steve Rapecki, Stevan Shaw, Pavan Vajjah, Shauna West, Meryn Griffiths
Published 2020-08-01

Isolation of antigen-specific, disulphide-rich knob domain peptides from bovine antibodies.

by Alex Macpherson, Anthony Scott-Tucker, Anastasios Spiliotopoulos, Catherine Simpson, Justin Staniforth, Adam Hold, James Snowden, Leah Manning, Jean van den Elsen, Alastair D G Lawson
Published 2020-09-01

A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

by Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O’Connell, Alastair D. G. Lawson
Published 2021-01-01

Insights Into the Structure-Function Relationships of Dimeric C3d Fragments

by Ayla A. Wahid, Rhys W. Dunphy, Alex Macpherson, Alex Macpherson, Beth G. Gibson, Liudmila Kulik, Kevin Whale, Catherine Back, Thomas M. Hallam, Bayan Alkhawaja, Rebecca L. Martin, Ingrid Meschede, Maisem Laabei, Alastair D. G. Lawson, V. Michael Holers, Andrew G. Watts, Andrew G. Watts, Susan J. Crennell, Claire L. Harris, Kevin J. Marchbank, Jean M. H. van den Elsen, Jean M. H. van den Elsen
Published 2021-08-01