mTOR Blockade by Rapamycin in Spondyloarthritis: Impact on Inflammation and New Bone Formation in vitro and in vivo

by Sijia Chen, Sijia Chen, Sijia Chen, Melissa N. van Tok, Melissa N. van Tok, Véronique L. Knaup, Lianne Kraal, Lianne Kraal, Désiree Pots, Désiree Pots, Lina Bartels, Ellen M. Gravallese, Joel D. Taurog, Marleen van de Sande, Marleen van de Sande, Leonie M. van Duivenvoorde, Leonie M. van Duivenvoorde, Dominique L. Baeten, Dominique L. Baeten, Dominique L. Baeten
Published 2020-02-01

Modulating Target Protein Biology Through the Re-mapping of Conformational Distributions Using Small Molecules

by Alastair D. G. Lawson, Malcolm MacCoss, Dominique L. Baeten, Alex Macpherson, Jiye Shi, Alistair J. Henry
Published 2021-05-01

Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

by Melissa N. van Tok, Melissa N. van Tok, Nimman Satumtira, Martha Dorris, Desirée Pots, Desirée Pots, Gleb Slobodin, Marleen G. van de Sande, Joel D. Taurog, Dominique L. Baeten, Dominique L. Baeten, Leonie M. van Duivenvoorde, Leonie M. van Duivenvoorde
Published 2017-08-01

Paradoxical Augmentation of Experimental Spondyloarthritis by RORC Inhibition in HLA-B27 Transgenic Rats

by Melissa N. van Tok, Melissa N. van Tok, Mohamed Mandour, Mohamed Mandour, Joseph Wahle, Mark E. Labadia, Marleen G. H. van de Sande, Marleen G. H. van de Sande, Gerald Nabozny, Dominique L. Baeten, Dominique L. Baeten, Leonie M. van Duivenvoorde, Leonie M. van Duivenvoorde
Published 2021-09-01

Soluble biomarkers of cartilage and bone metabolism in early proof of concept trials in psoriatic arthritis: effects of adalimumab versus placebo.

by Arno W R van Kuijk, Jeroen DeGroot, Rishma C Koeman, Nico Sakkee, Dominique L Baeten, Danielle M Gerlag, Paul P Tak
Published 2010-01-01

The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling

by Melissa N. van Tok, Melissa N. van Tok, Songqing Na, Christopher R. Lao, Marina Alvi, Desirée Pots, Desirée Pots, Marleen G. H. van de Sande, Marleen G. H. van de Sande, Joel D. Taurog, Jonathon D. Sedgwick, Jonathon D. Sedgwick, Dominique L. Baeten, Dominique L. Baeten, Leonie M. van Duivenvoorde, Leonie M. van Duivenvoorde
Published 2018-07-01

Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis.

by Melissa N van Tok, Nataliya G Yeremenko, Christine A Teitsma, Barbara E Kream, Véronique L Knaup, Rik J Lories, Dominique L Baeten, Leonie M van Duivenvoorde
Published 2016-01-01

Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: data from the spondyloarthritis caught early (SPACE) cohort

by Janneke J. de Winter, Marleen G. van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A. van Gaalen, Torsten Witte, Dominique L. Baeten
Published 2018-03-01

Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype.

by Samuel García, Sarah Krausz, Carmen A Ambarus, Beatriz Malvar Fernández, Linda M Hartkamp, Inge E van Es, Jörg Hamann, Dominique L Baeten, Paul P Tak, Kris A Reedquist
Published 2014-01-01

Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

by Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten, Timothy R. D. J. Radstake
Published 2018-07-01

Impact of the B Cell Growth Factor APRIL on the Qualitative and Immunological Characteristics of Atherosclerotic Plaques.

by Sophie J Bernelot Moens, Sander I van Leuven, Kang H Zheng, Stefan R Havik, Miranda V Versloot, Leonie M van Duivenvoorde, Michael Hahne, Erik S G Stroes, Dominique L Baeten, Anouk A J Hamers
Published 2016-01-01

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

by Yasunori Omata, Michael Frech, Tatjana Primbs, Sébastien Lucas, Darja Andreev, Carina Scholtysek, Kerstin Sarter, Markus Kindermann, Nataliya Yeremenko, Dominique L. Baeten, Nico Andreas, Thomas Kamradt, Aline Bozec, Andreas Ramming, Gerhard Krönke, Stefan Wirtz, Georg Schett, Mario M. Zaiss
Published 2018-07-01