Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF

by David McMillan, Carlos Martinez-Fleites, John Porter, David Fox, Rachel Davis, Prashant Mori, Tom Ceska, Bruce Carrington, Alastair Lawson, Tim Bourne, James O’Connell
Published 2021-01-01

Crystal structure of dopamine D1 receptor in complex with G protein and a non-catechol agonist

by Bingfa Sun, Dan Feng, Matthew Ling-Hon Chu, Inbar Fish, Silvia Lovera, Zara A. Sands, Sebastian Kelm, Anne Valade, Martyn Wood, Tom Ceska, Tong Sun Kobilka, Florence Lebon, Brian K. Kobilka
Published 2021-06-01

A conformation-selective monoclonal antibody against a small molecule-stabilised signalling-deficient form of TNF

by Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O’Connell, Alastair D. G. Lawson
Published 2021-01-01

Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimer

by James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne, Alastair Lawson
Published 2019-12-01