Article controlled study 311 human 300 Humans 225 nonhuman 222 genetics 215 male 179 female 169 unclassified drug 153 adult 150 gene expression 149 metabolism 132 human cell 107 Female 104 Male 101 messenger RNA 95 protein expression 93 major clinical study 89 upregulation 88 pathology 87 real time polymerase chain reaction 86 middle aged 85 gene expression regulation 84 human tissue 84 animal experiment 82 Middle Aged 78 down regulation 75 Animals 69 animal 69 aged 61