human 515 genetics 444 Article 439 Humans 423 controlled study 325 nonhuman 255 metabolism 248 RNA 213 male 209 female 201 gene expression 195 adult 167 unclassified drug 164 microRNA 149 messenger RNA 146 Female 136 Animals 134 animal 129 Male 127 gene expression regulation 117 pathology 116 human cell 112 MicroRNAs 110 protein expression 103 real time polymerase chain reaction 101 middle aged 98 upregulation 98 RNA sequencing 93 Middle Aged 91 major clinical study 89