The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours

by Rokaya El Ansari, Madeleine L. Craze, Islam Miligy, Maria Diez-Rodriguez, Christopher C. Nolan, Ian O. Ellis, Emad A. Rakha, Andrew R. Green
Published 2018-03-01

The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model

by Pascal Häfliger, Julien Graff, Matthias Rubin, Amandine Stooss, Matthias S. Dettmer, Karl-Heinz Altmann, Jürg Gertsch, Roch-Philippe Charles
Published 2018-09-01

Tumor Suppressor miR-184 Enhances Chemosensitivity by Directly Inhibiting SLC7A5 in Retinoblastoma

by Tian-Geng He, Zi-Yun Xiao, Zi-Yun Xiao, Yi-Qiao Xing, Hua-Jing Yang, Hong Qiu, Jian-Bin Chen
Published 2019-11-01

Glioblastoma Exhibits Inter-Individual Heterogeneity of TSPO and LAT1 Expression in Neoplastic and Parenchymal Cells

by Linzhi Cai, Sabrina V. Kirchleitner, Dongxu Zhao, Min Li, Jörg-Christian Tonn, Rainer Glass, Roland E. Kälin
Published 2020-01-01

Co-Expression Effect of SLC7A5/SLC3A2 to Predict Response to Endocrine Therapy in Oestrogen-Receptor-Positive Breast Cancer

by Lutfi H. Alfarsi, Rokaya El-Ansari, Madeleine L. Craze, Brendah K. Masisi, Omar J. Mohammed, Ian O. Ellis, Emad A. Rakha, Andrew R. Green
Published 2020-02-01

OIP5-AS1 contributes to the development in endometrial carcinoma cells by targeting miR-152-3p to up-regulate SLC7A5

by Minglin Liang, Hongbo Wang, Cong Liu, Tao Lei, Jie Min
Published 2021-08-01

Control of Slc7a5 sensitivity by the voltage-sensing domain of Kv1 channels

by Shawn M Lamothe, Nazlee Sharmin, Grace Silver, Motoyasu Satou, Yubin Hao, Toru Tateno, Victoria A Baronas, Harley T Kurata
Published 2020-11-01

Upregulation of the solute carrier family 7 genes is indicative of poor prognosis in papillary thyroid carcinoma

by Lei Shen, Chunhua Qian, Huimin Cao, Zhongrui Wang, Tingxian Luo, Chunli Liang
Published 2018-12-01

Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes

by Jing Xu, Congshan Jiang, Yongsong Cai, Yuanxu Guo, Xipeng Wang, Jiaxiang Zhang, Jiawen Xu, Ke Xu, Wenhua Zhu, Si Wang, Fujun Zhang, Manman Geng, Yan Han, Qilan Ning, Peng Xu, Liesu Meng, Shemin Lu
Published 2020-08-01

Abnormalities in the genes that encode Large Amino Acid Transporters increase the risk of Autism Spectrum Disorder

by Lauren Cascio, Chin‐Fu Chen, Rini Pauly, Sujata Srikanth, Kelly Jones, Cindy D. Skinner, Roger E. Stevenson, Charles E. Schwartz, Luigi Boccuto
Published 2020-01-01

The Regulation and Function of the L-Type Amino Acid Transporter 1 (LAT1) in Cancer

by Travis B Salisbury, Subha Arthur
Published 2018-08-01

Oncogenic MYC Activates a Feedforward Regulatory Loop Promoting Essential Amino Acid Metabolism and Tumorigenesis

by Ming Yue, Jue Jiang, Peng Gao, Hudan Liu, Guoliang Qing
Published 2017-12-01

Functional Polarity of Microvascular Brain Endothelial Cells Supported by Neurovascular Unit Computational Model of Large Neutral Amino Acid Homeostasis

by Mehdi Taslimifar, Mehdi Taslimifar, Stefano Buoso, Stefano Buoso, Francois Verrey, Francois Verrey, Francois Verrey, Vartan Kurtcuoglu, Vartan Kurtcuoglu, Vartan Kurtcuoglu, Vartan Kurtcuoglu
Published 2018-03-01

Methylmercury Uptake into BeWo Cells Depends on LAT2-4F2hc, a System L Amino Acid Transporter

by Christina Balthasar, Herbert Stangl, Raimund Widhalm, Sebastian Granitzer, Markus Hengstschläger, Claudia Gundacker
Published 2017-08-01

Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

by Angelika Bröer, Stephen Fairweather, Stefan Bröer
Published 2018-07-01

Targeting Amino Acid Metabolic Reprogramming via L-Type Amino Acid Transporter 1 (LAT1) for Endocrine-Resistant Breast Cancer

by Haruhiko Shindo, Narumi Harada-Shoji, Akiko Ebata, Miku Sato, Tomoyoshi Soga, Minoru Miyashita, Hiroshi Tada, Masaaki Kawai, Shinkichi Kosaka, Koji Onuki, Shin Usami, Shozo Furumoto, Shinichi Hayashi, Takaaki Abe, Takashi Suzuki, Takanori Ishida, Hironobu Sasano
Published 2021-08-01

The Harmonious Interplay of Amino Acid and Monocarboxylate Transporters Induces the Robustness of Cancer Cells

by Go J. Yoshida
Published 2021-01-01

Targeted Suppression and Knockout of ASCT2 or LAT1 in Epithelial and Mesenchymal Human Liver Cancer Cells Fail to Inhibit Growth

by Paige J. Bothwell, Clare D. Kron, Evan F. Wittke, Bradley N. Czerniak, Barrie P. Bode
Published 2018-07-01

Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1

by Palanivel Kandasamy, Inti Zlobec, Damian T. Nydegger, Jonai Pujol‐Giménez, Rajesh Bhardwaj, Senji Shirasawa, Toshiyuki Tsunoda, Matthias A. Hediger
Published 2021-10-01

A Proton-Coupled Transport System for β-Hydroxy-β-Methylbutyrate (HMB) in Blood–Brain Barrier Endothelial Cell Line hCMEC/D3

by Kei Higuchi, Sathish Sivaprakasam, Souad R. Sennoune, Jiro Ogura, Yangzom D. Bhutia, Ricardo Rueda, Suzette L. Pereira, Vadivel Ganapathy
Published 2021-09-01