An Integrated Mathematical Model of Cellular Cholesterol Biosynthesis and Lipoprotein Metabolism

by Frances Pool, Peter K. Sweby, Marcus J. Tindall
Published 2018-08-01

Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

by Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu
Published 2021-05-01

Oxymatrine Attenuates Osteoclastogenesis via Modulation of ROS-Mediated SREBP2 Signaling and Counteracts Ovariectomy-Induced Osteoporosis

by Chao Jiang, Chao Jiang, Qingliang Ma, Qingliang Ma, Shiyu Wang, Shiyu Wang, Yang Shen, Yang Shen, An Qin, Shunwu Fan, Shunwu Fan, Zhiwei Jie, Zhiwei Jie
Published 2021-05-01

Spermine synthesis inhibitor blocks 25-hydroxycholesterol-induced- apoptosis via SREBP2 upregulation in DLD-1 cell spheroids

by Miku Kakimoto, Hideya Yamamoto, Arowu R. Tanaka
Published 2020-07-01

Fibronectin Overexpression Modulates Formation of Macrophage Foam Cells by Activating SREBP2 Involved in Endoplasmic Reticulum Stress

by Hansong Du, Yu Wang, Zhengfeng Zhang, Jing Yang, Jie Zhang, Ying Zhang
Published 2015-07-01

Genistein upregulates LDLR levels via JNK-mediated activation of SREBP-2

by Medicia Kartawijaya, Hye Won Han, Yunhye Kim, Seung-Min Lee
Published 2016-05-01

Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-Cancer Effects in Hepatocellular Carcinoma Cells

by Geon-Hee Kim, Sang-Yeon Kan, Hyeji Kang, Sujin Lee, Hyun Myung Ko, Ji Hyung Kim, Ji-Hong Lim
Published 2019-09-01

Rutin and Quercetin Decrease Cholesterol in HepG2 Cells but Not Plasma Cholesterol in Hamsters by Oral Administration

by Ning Liang, Yuk-Man Li, Zouyan He, Wangjun Hao, Yimin Zhao, Jianhui Liu, Hanyue Zhu, Erika Kwek, Ka-Ying Ma, Wen-Sen He, Zhen-Yu Chen
Published 2021-06-01

Serum sdLDL-C and cellular SREBP2-dependent cholesterol levels: Is there a challenge on targeting PCSK9?

by Soltanmohammadi Elham, Piran Sadegh, Mohammadi Asghar, Hosseni Bita, Naseri Faezeh, Shabani Mohammad, Najafi Mohammad
Published 2016-01-01

Beneficial Effects of SREBP Decoy Oligodeoxynucleotide in an Animal Model of Hyperlipidemia

by Hyun-Jin An, Jung-Yeon Kim, Mi-Gyeong Gwon, Hyemin Gu, Hyun-Ju Kim, Jaechan Leem, Sung Won Youn, Kwan-Kyu Park
Published 2020-01-01

Cyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death

by Joseph Longo, Aleksandra A. Pandyra, Paweł Stachura, Mark D. Minden, Aaron D. Schimmer, Linda Z. Penn
Published 2020-10-01

Neoagarooligosaccharides enhance the level and efficiency of LDL receptor and improve cholesterol homeostasis

by Ji Hye Yang, Sam Seok Cho, Kyu Min Kim, Ji Young Kim, Eun Joo Kim, Eun Young Park, Je Hyeon Lee, Sung Hwan Ki
Published 2017-11-01

Targeting SREBP-2-Regulated Mevalonate Metabolism for Cancer Therapy

by Linyuan Xue, Hongyu Qi, He Zhang, Lu Ding, Qingxia Huang, Qingxia Huang, Daqing Zhao, Boyang Jason Wu, Xiangyan Li
Published 2020-08-01

Brahma Related Gene 1 (Brg1) Regulates Cellular Cholesterol Synthesis by Acting as a Co-factor for SREBP2

by Zhiwen Fan, Ming Kong, Min Li, Wenxuan Hong, Xiangshan Fan, Yong Xu, Yong Xu
Published 2020-05-01

Effect of a synthetic liver X receptor agonist TO901317 on cholesterol concentration in goose primary hepatocytes

by Fang He, Chunchun Han, Dandan Liu, Huofu Wan, Jiwen Wang, Hehe Liu, Liang Li, Hengyong Xu, Hua He
Published 2014-03-01

Role of leptin on the expression of low density lipoprotein receptor

by Naval Kishor Yadav, Albina Arjuman, Nimai C Chandra
Published 2014-01-01

Pterostilbene Increases LDL Metabolism in HL-1 Cardiomyocytes by Modulating the PCSK9/HNF1α/SREBP2/LDLR Signaling Cascade, Upregulating Epigenetic hsa-miR-335 and hsa-miR-6825, and...

by Yen-Kuang Lin, Chi-Tai Yeh, Kuang-Tai Kuo, Vijesh Kumar Yadav, Iat-Hang Fong, Nicholas G. Kounis, Patrick Hu, Ming-Yow Hung
Published 2021-08-01

The Cholesterol-Lowering Effect of Capsella Bursa-Pastoris Is Mediated via SREBP2 and HNF-1α-Regulated PCSK9 Inhibition in Obese Mice and HepG2 Cells

by Jin-Taek Hwang, Eunji Choi, Hyo-Kyoung Choi, Jae-Ho Park, Min-Yu Chung
Published 2021-02-01

Unripe <i>Rubus coreanus</i> Miquel Extract Containing Ellagic Acid Regulates AMPK, SREBP-2, HMGCR, and INSIG-1 Signaling and Cholesterol Metabolism In Vitro and In<i> </i>Vivo

by Ki Hoon Lee, Eui-Seon Jeong, Goeun Jang, Ju-Ryun Na, Soyi Park, Wan Seok Kang, Eun Kim, Hakjoon Choi, Jin Seok Kim, Sunoh Kim
Published 2020-02-01

Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors

by Trang Thi Thu Nguyen, Chiaki Tsuge Ishida, Enyuan Shang, Chang Shu, Elena Bianchetti, Georg Karpel-Massler, Markus D. Siegelin
Published 2019-06-01