Liquid–liquid phase separation in human health and diseases

by Bin Wang, Lei Zhang, Tong Dai, Ziran Qin, Huasong Lu, Long Zhang, Fangfang Zhou
Published 2021-08-01

Pattern recognition receptors in health and diseases

by Danyang Li, Minghua Wu
Published 2021-08-01

SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses

by Yuanmei Zhu, Danwei Yu, Yue Hu, Tong Wu, Huihui Chong, Yuxian He
Published 2021-08-01

TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity

by Xueer Wang, Honghai Zhang, Zhugui Shao, Wanxin Zhuang, Chao Sui, Feng Liu, Xiaorong Chen, Jinxiu Hou, Lingli Kong, Hansen Liu, Yi Zheng, Bingyu Liu, Tian Chen, Lei Zhang, Xinming Jia, Chengjiang Gao
Published 2021-08-01

Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence

by Ying Xu, Guan-Hua Su, Ding Ma, Yi Xiao, Zhi-Ming Shao, Yi-Zhou Jiang
Published 2021-08-01

Nicotinamide mononucleotide: a potential effective natural compound against insulin resistance

by Julian Roos, Julia Zinngrebe, Pamela Fischer-Posovszky
Published 2021-08-01

Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients

by Linlin Cheng, Xiaomei Zhang, Yu Chen, Dan Wang, Dong Zhang, Songxin Yan, Hongye Wang, Meng Xiao, Te Liang, Haolong Li, Meng Xu, Xin Hou, jiayu Dai, Xian Wu, Mingyuan Li, Minya Lu, Dong Wu, Ran Tian, Jing Zhao, Yan Zhang, Wei Cao, Jinglan Wang, Xiaowei Yan, Xiang Zhou, Zhengyin Liu, Yingchun Xu, Fuchu He, Yongzhe Li, Xiaobo Yu, Shuyang Zhang
Published 2021-08-01

WWP1 targeting MUC1 for ubiquitin-mediated lysosomal degradation to suppress carcinogenesis

by Chunhua Liao, Liping Yu, Zhi Pang, Huayun Deng, Xiaodong Liao, Shengze Li, Jinke Cheng, Min Qi, Guoqiang Chen, Lei Huang
Published 2021-08-01

Cyro-EM structure of human mGlus: leading therapeutic potential to neurological diseases

by Huan Xiao, Qiu Sun
Published 2021-08-01

Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

by Ruoxi Xie, Zijun Wu, Fanxin Zeng, Huawei Cai, Dan Wang, Lei Gu, Hongyan Zhu, Su Lui, Gang Guo, Bin Song, Jinxing Li, Min Wu, Qiyong Gong
Published 2021-08-01

BCL9 regulates CD226 and CD96 checkpoints in CD8+ T cells to improve PD-1 response in cancer

by Mei Feng, Zhongen Wu, Yan Zhou, Zhuang Wei, Enming Tian, Shenglin Mei, Yuanyuan Zhu, Chenglong Liu, Fenglian He, Huiyu Li, Cao Xie, Joy Jin, Jibin Dong, Dehua Yang, Ker Yu, Junbin Qian, Diether Lambrechts, Ming-Wei Wang, Di Zhu
Published 2021-08-01

“Armed for the future Coronavirus pandemic”: a promising use of the multimeric SARS-CoV-2 receptor binding domain nanoparticle as a new Pan-Coronavirus vaccine

by Manoj Kumar, Souhaila Al Khodor
Published 2021-08-01

Glucose-sensitive acetylation of Seryl tRNA synthetase regulates lipid synthesis in breast cancer

by Jin Zhao, Hangming Bai, Xiaoyu Li, Jie Yan, Gengyi Zou, Longlong Wang, Xiru Li, Ze Liu, Rong Xiang, Xiang-Lei Yang, Yi Shi
Published 2021-08-01

HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19

by Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo, Qiwei Zhang, Jianguo Wu
Published 2021-08-01

Insights from the degradation mechanism of cyclin D into targeted therapy of the cancer cell cycle

by Maiwen Caudron-Herger, Sven Diederichs
Published 2021-08-01

Assessment of infectivity and the impact on neutralizing activity of immune sera of the COVID-19 variant, CAL.20C

by Zhongcheng Zhou, Peng Du, Meixing Yu, Daniel T. Baptista-Hon, Man Miao, Andy P. Xiang, Johnson Yiu-Nam Lau, COVID-19 Immunity Investigation Group, Gen Li, Kang Zhang
Published 2021-07-01

Somatic mutations predict prognosis in myelodysplastic syndrome patients with normal karyotypes

by Xiangzong Zeng, Yu Zhang, Ke Zhao, Lingling Zhou, Ya Zhou, Li Xuan, Rui Cao, Jun Xu, Min Dai, Qifa Liu
Published 2021-07-01

Spontaneous apoptosis of cells in therapeutic stem cell preparation exert immunomodulatory effects through release of phosphatidylserine

by Xuemei He, Weiqi Hong, Jingyun Yang, Hong Lei, Tianqi Lu, Cai He, Zhenfei Bi, Xiangyu Pan, Yu Liu, Lunzhi Dai, Wei Wang, Canhua Huang, Hongxin Deng, Xiawei Wei
Published 2021-07-01

Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

by Cameron Mura, Saskia Preissner, Susanne Nahles, Max Heiland, Philip E. Bourne, Robert Preissner
Published 2021-07-01

PTEN suppresses tumorigenesis by directly dephosphorylating Akt

by Lang Bu, Huan Wang, Ji-an Pan, Lang Chen, Fan Xing, Junyu Wu, Shun Li, Deyin Guo
Published 2021-07-01