Dystrophin R16/17-syntrophin PDZ fusion protein restores sarcolemmal nNOSμ

by Aman Patel, Junling Zhao, Yongping Yue, Keqing Zhang, Dongsheng Duan, Yi Lai
Published 2018-11-01

Acute conversion of patient-derived Duchenne muscular dystrophy iPSC into myotubes reveals constitutive and inducible over-activation of TGFβ-dependent pro-fibrotic signaling

by Luca Caputo, Alice Granados, Jessica Lenzi, Alessandro Rosa, Slimane Ait-Si-Ali, Pier Lorenzo Puri, Sonia Albini
Published 2020-05-01

Muscle injury-induced hypoxia alters the proliferation and differentiation potentials of muscle resident stromal cells

by Geneviève Drouin, Vanessa Couture, Marc-Antoine Lauzon, Frédéric Balg, Nathalie Faucheux, Guillaume Grenier
Published 2019-06-01

RNA-sequencing reveals altered skeletal muscle contraction, E3 ligases, autophagy, apoptosis, and chaperone expression in patients with critical illness myopathy

by Monica Llano-Diez, Wen Fury, Haruka Okamoto, Yu Bai, Jesper Gromada, Lars Larsson
Published 2019-04-01

Congenital myopathy with hanging big toe due to homozygous myopalladin (MYPN) mutation

by Luciano Merlini, Patrizia Sabatelli, Manuela Antoniel, Valeria Carinci, Fabio Niro, Giuseppe Monetti, Annalaura Torella, Teresa Giugliano, Cesare Faldini, Vincenzo Nigro
Published 2019-05-01

X-linked muscular dystrophy in a Labrador Retriever strain: phenotypic and molecular characterisation

by Inès Barthélémy, Nadège Calmels, Robert B. Weiss, Laurent Tiret, Adeline Vulin, Nicolas Wein, Cécile Peccate, Carole Drougard, Christophe Beroud, Nathalie Deburgrave, Jean-Laurent Thibaud, Catherine Escriou, Isabel Punzón, Luis Garcia, Jean-Claude Kaplan, Kevin M. Flanigan, France Leturcq, Stéphane Blot
Published 2020-08-01

Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity

by Takako I. Jones, Guo-Liang Chew, Pamela Barraza-Flores, Spencer Schreier, Monique Ramirez, Ryan D. Wuebbles, Dean J. Burkin, Robert K. Bradley, Peter L. Jones
Published 2020-04-01

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

by Neena Lala-Tabbert, Rim Lejmi-Mrad, Kristen Timusk, Marina Fukano, Janelle Holbrook, Martine St-Jean, Eric C. LaCasse, Robert G. Korneluk
Published 2019-05-01

Pluripotent stem cell-derived skeletal muscle fibers preferentially express myosin heavy-chain isoforms associated with slow and oxidative muscles

by Tania Incitti, Alessandro Magli, Asher Jenkins, Karena Lin, Ami Yamamoto, Rita C. R. Perlingeiro
Published 2020-06-01

Exercise enhances mitochondrial fission and mitophagy to improve myopathy following critical limb ischemia in elderly mice via the PGC1a/FNDC5/irisin pathway

by Wuyang He, Peng Wang, Qingwei Chen, Chunqiu Li
Published 2020-09-01

Efficient engraftment of pluripotent stem cell-derived myogenic progenitors in a novel immunodeficient mouse model of limb girdle muscular dystrophy 2I

by Karim Azzag, Carolina Ortiz-Cordero, Nelio A. J. Oliveira, Alessandro Magli, Sridhar Selvaraj, Sudheer Tungtur, Weston Upchurch, Paul A. Iaizzo, Qi Long Lu, Rita C. R. Perlingeiro
Published 2020-04-01

HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses

by Eva Pigna, Alessandra Renzini, Emanuela Greco, Elena Simonazzi, Stefania Fulle, Rosa Mancinelli, Viviana Moresi, Sergio Adamo
Published 2018-02-01

Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells

by Dimuthu K. Wasgewatte Wijesinghe, Eleanor J. Mackie, Charles N. Pagel
Published 2019-02-01

Exclusive vital labeling of myonuclei for studying myonuclear arrangement in mouse skeletal muscle tissue

by Robert Louis Hastings, Ryan T. Massopust, Seth G. Haddix, Young il Lee, Wesley J. Thompson
Published 2020-05-01

Angiotensin-converting-enzyme inhibitor prevents skeletal muscle fibrosis in myocardial infarction mice

by Naoya Kakutani, Shingo Takada, Hideo Nambu, Junichi Matsumoto, Takaaki Furihata, Takashi Yokota, Arata Fukushima, Shintaro Kinugawa
Published 2020-04-01

SMN-deficiency disrupts SERCA2 expression and intracellular Ca2+ signaling in cardiomyocytes from SMA mice and patient-derived iPSCs

by Guzal Khayrullina, Kasey E. Moritz, James F. Schooley, Naheed Fatima, Coralie Viollet, Nikki M. McCormack, Jeremy T. Smyth, Martin L. Doughty, Clifton L. Dalgard, Thomas P. Flagg, Barrington G. Burnett
Published 2020-05-01

Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle

by Tahnee L. Kennedy, Lee Moir, Sarah Hemming, Ben Edwards, Sarah Squire, Kay Davies, Simon Guiraud
Published 2017-10-01

β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility

by Jihee Kim, Chad A. Grotegut, James W. Wisler, Tianyu Li, Lan Mao, Minyong Chen, Wei Chen, Paul B. Rosenberg, Howard A. Rockman, Robert J. Lefkowitz
Published 2018-12-01

Dilated cardiomyopathy-mediated heart failure induces a unique skeletal muscle myopathy with inflammation

by Taejeong Song, Palanikumar Manoharan, Douglas P. Millay, Sheryl E. Koch, Jack Rubinstein, Judith A. Heiny, Sakthivel Sadayappan
Published 2019-01-01

Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction

by Craig L. Doig, Agnieszka E. Zielinska, Rachel S. Fletcher, Lucy A. Oakey, Yasir S. Elhassan, Antje Garten, David Cartwright, Silke Heising, Ahmed Alsheri, David G. Watson, Cornelia Prehn, Jerzy Adamski, Daniel A. Tennant, Gareth G. Lavery
Published 2020-02-01