Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome

by Yuhei Mizunoe, Masaki Kobayashi, Ryoma Tagawa, Yoshimi Nakagawa, Hitoshi Shimano, Yoshikazu Higami
Published 2019-07-01

Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

by Ria Thomas, Elizabeth B. Moloney, Zachary K. Macbain, Penelope J. Hallett, Ole Isacson
Published 2021-01-01

Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson's Disease

by Juan Segura-Aguilar, Sandro Huenchuguala
Published 2018-03-01

Insight into the Role of Extracellular Vesicles in Lysosomal Storage Disorders

by Brunella Tancini, Sandra Buratta, Krizia Sagini, Eva Costanzi, Federica Delo, Lorena Urbanelli, Carla Emiliani
Published 2019-07-01

Hermansky–Pudlak syndrome with interstitial lung disease: A holistically worked up couplet

by Abhishek Gupta, Ketaki Utpat, Unnati Desai, Jyotsna M Joshi
Published 2019-01-01

Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis

by Katarzyna Bocheńska, Magdalena Gabig-Cimińska
Published 2020-03-01

Iron in Neurodegeneration – Cause or Consequence?

by Alain Ndayisaba, Christine Kaindlstorfer, Gregor K. Wenning
Published 2019-03-01

Lipids, lysosomes, and autophagy

by Bharat Jaishy, E.Dale Abel
Published 2016-09-01

Diclofenac impairs autophagic flux via oxidative stress and lysosomal dysfunction: Implications for hepatotoxicity

by Seung-Hwan Jung, Wonseok Lee, Seung-Hyun Park, Kang-Yo Lee, You-Jin Choi, Soohee Choi, Dongmin Kang, Sinri Kim, Tong-Shin Chang, Soon-Sun Hong, Byung-Hoon Lee
Published 2020-10-01

Persistent reduction in sialylation of cerebral glycoproteins following postnatal inflammatory exposure

by Ekaterina P. Demina, Wyston C. Pierre, Annie L. A. Nguyen, Irene Londono, Bela Reiz, Chunxia Zou, Radhika Chakraberty, Christopher W. Cairo, Alexey V. Pshezhetsky, Gregory A. Lodygensky
Published 2018-12-01

Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice

by Jonathan Frew, Haakon Berge Nygaard
Published 2021-04-01

Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease

by Caleb Pitcairn, Willayat Yousuf Wani, Joseph R. Mazzulli
Published 2019-02-01

The marker of cobalamin deficiency, plasma methylmalonic acid, may help identifying lysosomal iron trapping in patients. Its possible utility for heart failure

by Alphons J.M. Vermorken, Jingjing Zhu, Paul Holvoet, Yali Cui
Published 2021-08-01

Vesicular Dysfunction and the Pathogenesis of Parkinson’s Disease: Clues From Genetic Studies

by Kirsten Ebanks, Kirsten Ebanks, Patrick A. Lewis, Patrick A. Lewis, Rina Bandopadhyay, Rina Bandopadhyay
Published 2020-01-01

Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease

by Leanne K. Hein, Stephen Duplock, Maria Fuller
Published 2013-06-01

Could the Inhibition of Endo-Lysosomal Two-Pore Channels (TPCs) by the Natural Flavonoid Naringenin Represent an Option to Fight SARS-CoV-2 Infection?

by Antonio Filippini, Antonella D'Amore, Fioretta Palombi, Armando Carpaneto, Armando Carpaneto
Published 2020-04-01

LRRK2 Kinase Inhibition Rescues Deficits in Lysosome Function Due to Heterozygous GBA1 Expression in Human iPSC-Derived Neurons

by Anwesha Sanyal, Hailey S. Novis, Emile Gasser, Steven Lin, Matthew J. LaVoie
Published 2020-05-01

Bovine Milk Lactoferrin Selectively Kills Highly Metastatic Prostate Cancer PC-3 and Osteosarcoma MG-63 Cells In Vitro

by Joana P. Guedes, Joana P. Guedes, Cátia S. Pereira, Cátia S. Pereira, Lígia R. Rodrigues, Manuela Côrte-Real
Published 2018-06-01

Alteration in Intracellular Zn2+ Homeostasis as a Result of TRPM2 Channel Activation Contributes to ROS-Induced Hippocampal Neuronal Death

by Xin Li, Wei Yang, Wei Yang, Lin-Hua Jiang, Lin-Hua Jiang
Published 2017-12-01

Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson’s disease pathogenesis

by Stefanie Smolders, Christine Van Broeckhoven
Published 2020-05-01