Exploring the Ubiquitin-Proteasome System (UPS) through PROTAC Technology

by Carlotta Cecchini, Sébastien Tardy, Valentina Ceserani, Jean-Philippe Theurillat, Leonardo Scapozza
Published 2020-04-01

Targeting the CDK6 Dependence of Ph+ Acute Lymphoblastic Leukemia

by Patrizia Porazzi, Marco De Dominici, Joseph Salvino, Bruno Calabretta
Published 2021-08-01

Ubiquitination of Nonhistone Proteins in Cancer Development and Treatment

by Xiuzhen Zhang, Tong Meng, Shuaishuai Cui, Ling Feng, Dongwu Liu, Dongwu Liu, Qiuxiang Pang, Ping Wang
Published 2021-02-01

Applications of Bacterial Degrons and Degraders — Toward Targeted Protein Degradation in Bacteria

by Matylda Anna Izert, Maria Magdalena Klimecka, Maria Wiktoria Górna
Published 2021-05-01

Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer

by Giovanni L. Beretta, Nadia Zaffaroni
Published 2019-05-01

From Conception to Development: Investigating PROTACs Features for Improved Cell Permeability and Successful Protein Degradation

by Carlotta Cecchini, Carlotta Cecchini, Sara Pannilunghi, Sara Pannilunghi, Sébastien Tardy, Sébastien Tardy, Leonardo Scapozza, Leonardo Scapozza
Published 2021-04-01

Proteolysis Targeting Chimeras for BTK Efficiently Inhibit B-Cell Receptor Signaling and Can Overcome Ibrutinib Resistance in CLL Cells

by Yamit Shorer Arbel, Ben-Zion Katz, Ben-Zion Katz, Ronen Gabizon, Amit Shraga, Yotam Bronstein, Talia Kamdjou, Anat Globerson Levin, Chava Perry, Chava Perry, Irit Avivi, Irit Avivi, Nir London, Yair Herishanu, Yair Herishanu
Published 2021-05-01

PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors

by Peiyi Zhang, Xuan Zhang, Xingui Liu, Sajid Khan, Daohong Zhou, Guangrong Zheng
Published 2020-08-01

Photopharmacology of Proteolysis-Targeting Chimeras: A New Frontier for Drug Discovery

by Shenxin Zeng, Shenxin Zeng, Hongjie Zhang, Hongjie Zhang, Zhengrong Shen, Zhengrong Shen, Wenhai Huang, Wenhai Huang
Published 2021-03-01

Role of BET Proteins in Inflammation and CNS Diseases

by Lei Liu, Changjun Yang, Eduardo Candelario-Jalil
Published 2021-09-01

Development of PROTACs to address clinical limitations associated with BTK-targeted kinase inhibitors

by Rachael Arthur, Beatriz Valle-Argos, Andrew J. Steele, Graham Packham
Published 2020-06-01

Development of Dual ARV-825 and Nintedanib-Loaded PEGylated Nano-Liposomes for Synergistic Efficacy in Vemurafnib-Resistant Melanoma

by Yige Fu, Aishwarya Saraswat, Zenghui Wei, Manas Yogendra Agrawal, Vikas V. Dukhande, Sandra E. Reznik, Ketan Patel
Published 2021-07-01

New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities

by Marcin Cieślak, Julia Kaźmierczak-Barańska, Karolina Królewska-Golińska, Mariola Napiórkowska, Iga Stukan, Urszula Wojda, Barbara Nawrot
Published 2019-09-01

Proteolysis targeting chimera technology: a novel strategy for treating diseases of the central nervous system

by Ke Ma, Xiao-Xiao Han, Xiao-Ming Yang, Song-Lin Zhou
Published 2021-01-01

Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors

by Gabriel LaPlante, Wei Zhang
Published 2021-06-01

Inhibitory effect on the proteasome regulatory subunit, RPN11/POH1, with the use of Capzimin-PROTAC to trigger apoptosis in cancer cells

by Holmqvist, Andreas
Published 2020