Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

by Nicholas F. Fitz, Cody M. Wolfe, Brittany E. Playso, Richard J. Biedrzycki, Yi Lu, Kyong Nyon Nam, Iliya Lefterov, Radosveta Koldamova
Published 2020-07-01

Dynamic changes of CSF sTREM2 in preclinical Alzheimer’s disease: the CABLE study

by Ling-Zhi Ma, Lan Tan, Yan-Lin Bi, Xue-Ning Shen, Wei Xu, Ya-Hui Ma, Hong-Qi Li, Qiang Dong, Jin-Tai Yu
Published 2020-04-01

The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer’s Disease

by Li Zhong, Xiao-Fen Chen, Xiao-Fen Chen
Published 2019-11-01

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

by Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao-Fen Chen
Published 2018-03-01

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

by Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Huaxi Xu, Guojun Bu, Guojun Bu, Xiao-Fen Chen, Xiao-Fen Chen
Published 2017-06-01

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

by Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Todd E Golde
Published 2018-11-01

Neuroinflammation in Alzheimer's disease continuum

by Aslihan Taskiran-Sag, Müge Yemişçi
Published 2020-01-01

Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker

by Xin Cheng, Xiaowei Wang, Kechao Nie, Lin Cheng, Zheyu Zhang, Yang Hu, Weijun Peng
Published 2021-02-01

Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer’s disease models

by Michael Fassler, Maya Saban Rappaport, Clara Benaim Cuño, Jacob George
Published 2021-01-01

TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding

by Can Liu, Pinhao Li, Hui Li, Sicong Wang, Lifeng Ding, Hanbin Wang, Hui Ye, Yue Jin, Jinchao Hou, Xiangming Fang, Qiang Shu
Published 2019-09-01

Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup

by Ione O. C. Woollacott, Jennifer M. Nicholas, Amanda Heslegrave, Carolin Heller, Martha S. Foiani, Katrina M. Dick, Lucy L. Russell, Ross W. Paterson, Ashvini Keshavan, Nick C. Fox, Jason D. Warren, Jonathan M. Schott, Henrik Zetterberg, Jonathan D. Rohrer
Published 2018-08-01

Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities

by Hailan Yao, Hailan Yao, Kyle Coppola, Kyle Coppola, Jonas Elias Schweig, Jonas Elias Schweig, Fiona Crawford, Fiona Crawford, Michael Mullan, Michael Mullan, Daniel Paris, Daniel Paris
Published 2019-10-01

Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation

by Alejandro Carrillo-Jimenez, Alejandro Carrillo-Jimenez, Mar Puigdellívol, Anna Vilalta, Jose Luis Venero, Jose Luis Venero, Guy Charles Brown, Peter StGeorge-Hyslop, Miguel Angel Burguillos
Published 2018-09-01

New insights into the role of TREM2 in Alzheimer’s disease

by Maud Gratuze, Cheryl E. G. Leyns, David M. Holtzman
Published 2018-12-01

CSF sTREM2 in delirium—relation to Alzheimer’s disease CSF biomarkers Aβ42, t-tau and p-tau

by Kristi Henjum, Else Quist-Paulsen, Henrik Zetterberg, Kaj Blennow, Lars N. G. Nilsson, Leiv Otto Watne
Published 2018-11-01

Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease

by Estella A. Newcombe, Judith Camats-Perna, Mallone L. Silva, Nicholas Valmas, Tee Jong Huat, Rodrigo Medeiros
Published 2018-09-01

An analysis of modifiable risk factors, genetic underpinnings, and current medications for Alzheimer's disease

by Bailey, Jack
Published 2019

Microglial Function and Regulation during Development, Homeostasis and Alzheimer’s Disease

by Brad T. T. Casali, Erin G. G. Reed-Geaghan
Published 2021-04-01

Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Surviva...

by Baoying Cheng, Xin Li, Kai Dai, Shengshun Duan, Zhouyi Rong, Yingmin Chen, Liangcheng Lü, Zhaoji Liu, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang, Honghua Zheng, Honghua Zheng
Published 2021-03-01

Differential accumulation of storage bodies with aging defines discrete subsets of microglia in the healthy brain

by Burns, Jeremy Carlos
Published 2021