A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity.

by Iana Parvanova, Sabrina Epiphanio, Abdul Fauq, Todd E Golde, Miguel Prudêncio, Maria M Mota
Published 2009-01-01

Targeting psychologic stress signaling pathways in Alzheimer’s disease

by Hunter S. Futch, Cara L. Croft, Van Q. Truong, Eric G. Krause, Todd E. Golde
Published 2017-06-01

Fyn depletion ameliorates tauP301L-induced neuropathology

by Guanghao Liu, Kimberly L. Fiock, Yona Levites, Todd E. Golde, Marco M. Hefti, Gloria Lee
Published 2020-07-01

Designing antibodies against LRRK2-targeted tau epitopes.

by Matthew Hamm, Thomas B Ladd, Yona Levites, Todd E Golde, Benoit I Giasson, Jada Lewis
Published 2018-01-01

Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice

by Tuhina Prasad, Ping Zhu, Amrisha Verma, Paramita Chakrabarty, Awilda M. Rosario, Todd E. Golde, Qiuhong Li
Published 2017-06-01

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).

by Christian B Lessard, Barbara A Cottrell, Hiroko Maruyama, Suraj Suresh, Todd E Golde, Edward H Koo
Published 2015-01-01

Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration

by Michael R. Strickland, Emily J. Koller, Doris Z. Deng, Carolina Ceballos-Diaz, Todd E. Golde, Paramita Chakrabarty
Published 2018-02-01

Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.

by Yong Ran, Gabriela Z Ladd, Carolina Ceballos-Diaz, Joo In Jung, Doron Greenbaum, Kevin M Felsenstein, Todd E Golde
Published 2015-01-01

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.

by Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasson
Published 2018-01-01

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.

by Jess-Karan S Dhillon, Cara Riffe, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Todd E Golde, Benoit I Giasson
Published 2017-01-01

Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model.

by Andrew T N Tebbenkamp, Keith W Crosby, Zoe B Siemienski, Hilda H Brown, Todd E Golde, David R Borchelt
Published 2012-01-01

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

by Zachary A. Sorrentino, Mieu M.T. Brooks, Vincent Hudson, Nicola J. Rutherford, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty
Published 2017-05-01

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

by Kevin H. Strang, Marshall S. Goodwin, Cara Riffe, Brenda D. Moore, Paramita Chakrabarty, Yona Levites, Todd E. Golde, Benoit I. Giasson
Published 2017-07-01

Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization.

by Yiying Zhang, Yu Zhen, Yuanlin Dong, Zhipeng Xu, Yun Yue, Todd E Golde, Rudolph E Tanzi, Robert D Moir, Zhongcong Xie
Published 2011-01-01

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

by Christian B. Lessard, Edgardo Rodriguez, Thomas B. Ladd, Lisa M. Minter, Barbara A. Osborne, Lucio Miele, Todd E. Golde, Yong Ran
Published 2020-05-01

Free-water imaging of the hippocampus is a sensitive marker of Alzheimer's disease

by Edward Ofori, Steven T. DeKosky, Marcelo Febo, Luis Colon-Perez, Paramita Chakrabarty, Ranjan Duara, Malek Adjouadi, Todd E. Golde, David E. Vaillancourt
Published 2019-01-01

Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity.

by Joo In Jung, Sasha Premraj, Pedro E Cruz, Thomas B Ladd, Yewon Kwak, Edward H Koo, Kevin M Felsenstein, Todd E Golde, Yong Ran
Published 2014-01-01

Precision therapeutic targets for COVID-19

by Zachary A. Krumm, Grace M. Lloyd, Connor P. Francis, Lith H. Nasif, Duane A. Mitchell, Todd E. Golde, Benoit I. Giasson, Yuxing Xia
Published 2021-03-01

Cholesterol-Dependent γ-Secretase Activity in Buoyant Cholesterol-Rich Membrane Microdomains

by Suzanne Wahrle, Pritam Das, Andrew C. Nyborg, Chris McLendon, Mikio Shoji, Takeshi Kawarabayashi, Linda H. Younkin, Steven G. Younkin, Todd E. Golde
Published 2002-02-01

Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis

by Guilian Xu, Susan E. Fromholt, Paramita Chakrabarty, Fanchao Zhu, Xuefei Liu, Michael C. Pace, Jin Koh, Todd E. Golde, Yona Levites, Jada Lewis, David R. Borchelt
Published 2020-04-01