“Don’t Phos Over Tau”: recent developments in clinical biomarkers and therapies targeting tau phosphorylation in Alzheimer’s disease and other tauopathies

by Yuxing Xia, Stefan Prokop, Benoit I. Giasson
Published 2021-06-01

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation

by Yuxing Xia, Brach M. Bell, Benoit I. Giasson
Published 2021-08-01

The ER retention protein RER1 promotes alpha-synuclein degradation via the proteasome.

by Hyo-Jin Park, Daniel Ryu, Mayur Parmar, Benoit I Giasson, Nikolaus R McFarland
Published 2017-01-01

Designing antibodies against LRRK2-targeted tau epitopes.

by Matthew Hamm, Thomas B Ladd, Yona Levites, Todd E Golde, Benoit I Giasson, Jada Lewis
Published 2018-01-01

Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology

by Michael C. Pace, Guilian Xu, Susan Fromholt, John Howard, Benoit I. Giasson, Jada Lewis, David R. Borchelt
Published 2018-05-01

Robust α-synuclein pathology in select brainstem neuronal populations is a potential instigator of multiple system atrophy

by Ethan W. Hass, Zachary A. Sorrentino, Grace M. Lloyd, Nikolaus R. McFarland, Stefan Prokop, Benoit I. Giasson
Published 2021-05-01

Novel monoclonal antibodies targeting the microtubule-binding domain of human tau.

by Cara L Croft, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E Golde, Benoit I Giasson
Published 2018-01-01

A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.

by Jess-Karan S Dhillon, Cara Riffe, Brenda D Moore, Yong Ran, Paramita Chakrabarty, Todd E Golde, Benoit I Giasson
Published 2017-01-01

Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity

by Zachary A. Sorrentino, Mieu M.T. Brooks, Vincent Hudson, Nicola J. Rutherford, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty
Published 2017-05-01

Disease-, region- and cell type specific diversity of α-synuclein carboxy terminal truncations in synucleinopathies

by Ethan W. Hass, Zachary A. Sorrentino, Yuxing Xia, Grace M. Lloyd, John Q. Trojanowski, Stefan Prokop, Benoit I. Giasson
Published 2021-08-01

Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau

by Kevin H. Strang, Marshall S. Goodwin, Cara Riffe, Brenda D. Moore, Paramita Chakrabarty, Yona Levites, Todd E. Golde, Benoit I. Giasson
Published 2017-07-01

Fragile X-associated tremor ataxia syndrome with co-occurrent progressive supranuclear palsy-like neuropathology

by Amanda N. Sacino, Stefan Prokop, Meggen A. Walsh, Jennifer Adamson, S. H. Subramony, Amy Krans, Peter K. Todd, Benoit I. Giasson, Anthony T. Yachnis
Published 2019-10-01

Comparative analyses of the in vivo induction and transmission of α-synuclein pathology in transgenic mice by MSA brain lysate and recombinant α-synuclein fibrils

by Jess-Karan S. Dhillon, Jorge A. Trejo-Lopez, Cara Riffe, Yona Levites, Amanda N. Sacino, David R. Borchelt, Anthony Y. Yachnis, Benoit I. Giasson
Published 2019-05-01

Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

by Grace M. Lloyd, Jess-Karan S. Dhillon, Kimberly-Marie M. Gorion, Cara Riffe, Susan E. Fromholt, Yuxing Xia, Benoit I. Giasson, David R. Borchelt
Published 2021-09-01

Precision therapeutic targets for COVID-19

by Zachary A. Krumm, Grace M. Lloyd, Connor P. Francis, Lith H. Nasif, Duane A. Mitchell, Todd E. Golde, Benoit I. Giasson, Yuxing Xia
Published 2021-03-01

Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier – phenotypic variability in autosomal dominant Alzheimer’s disease

by Grace M. Lloyd, Jorge A. Trejo-Lopez, Yuxing Xia, Karen N. McFarland, Sarah J. Lincoln, Nilüfer Ertekin-Taner, Benoit I. Giasson, Anthony T. Yachnis, Stefan Prokop
Published 2020-03-01

Tau Ser208 phosphorylation promotes aggregation and reveals neuropathologic diversity in Alzheimer’s disease and other tauopathies

by Yuxing Xia, Stefan Prokop, Kimberly-Marie M. Gorion, Justin D. Kim, Zachary A. Sorrentino, Brach M. Bell, Alyssa N. Manaois, Paramita Chakrabarty, Peter Davies, Benoit I. Giasson
Published 2020-06-01

Unique α-synuclein pathology within the amygdala in Lewy body dementia: implications for disease initiation and progression

by Zachary A. Sorrentino, Marshall S. Goodwin, Cara J. Riffe, Jess-Karan S. Dhillon, Yuxing Xia, Kimberly-Marie Gorion, Niran Vijayaraghavan, Karen N. McFarland, Lawrence I. Golbe, Anthony T. Yachnis, Benoit I. Giasson
Published 2019-09-01

Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration

by Zachary A. Sorrentino, Yuxing Xia, Cory Funk, Cara J. Riffe, Nicola J. Rutherford, Carolina Ceballos Diaz, Amanda N. Sacino, Nathan D. Price, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty
Published 2018-12-01

Il-10 signaling reduces survival in mouse models of synucleinopathy

by Samuel G. Cockey, Karen N. McFarland, Emily J. Koller, Mieu M. T. Brooks, Elsa Gonzalez De La Cruz, Pedro E. Cruz, Carolina Ceballos-Diaz, Awilda M. Rosario, Yona R. Levites, David R. Borchelt, Todd E. Golde, Benoit I. Giasson, Paramita Chakrabarty
Published 2021-03-01