The Role of APOE and TREM2 in Alzheimer′s Disease—Current Understanding and Perspectives

by Cody M. Wolfe, Nicholas F. Fitz, Kyong Nyon Nam, Iliya Lefterov, Radosveta Koldamova
Published 2018-12-01

Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment

by Yuteng Weng, Haicheng Wang, Lin Li, Yanhuizhi Feng, Shuyu Xu, Zuolin Wang
Published 2021-04-01

Alzheimer’s Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia

by Marvin Reich, Marvin Reich, Iñaki Paris, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A. Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschgi
Published 2021-02-01

Microglial Hyperreactivity Evolved to Immunosuppression in the Hippocampus of a Mouse Model of Accelerated Aging and Alzheimer’s Disease Traits

by Patricia Molina-Martínez, Rubén Corpas, Rubén Corpas, Elisa García-Lara, Elisa García-Lara, Marta Cosín-Tomás, Rosa Cristòfol, Perla Kaliman, Perla Kaliman, Carme Solà, Carme Solà, José Luis Molinuevo, José Luis Molinuevo, José Luis Molinuevo, José Luis Molinuevo, Raquel Sánchez-Valle, Raquel Sánchez-Valle, Raquel Sánchez-Valle, Anna Antonell, Anna Antonell, Anna Antonell, Albert Lladó, Albert Lladó, Albert Lladó, Coral Sanfeliu, Coral Sanfeliu
Published 2021-01-01

Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila models

by Michiko Sekiya, Minghui Wang, Naoki Fujisaki, Yasufumi Sakakibara, Xiuming Quan, Michelle E. Ehrlich, Philip L. De Jager, David A. Bennett, Eric E. Schadt, Sam Gandy, Kanae Ando, Bin Zhang, Koichi M. Iijima
Published 2018-03-01