Autophagy stimulation reduces ocular hypertension in a murine glaucoma model via autophagic degradation of mutant myocilin

by Ramesh B. Kasetti, Prabhavathi Maddineni, Charles Kiehlbauch, Shruti Patil, Charles C. Searby, Beth Levine, Val C. Sheffield, Gulab S. Zode
Published 2021-03-01

Human C. difficile toxin–specific memory B cell repertoires encode poorly neutralizing antibodies

by Hemangi B. Shah, Kenneth Smith, Edgar J. Scott II, Jason L. Larabee, Judith A. James, Jimmy D. Ballard, Mark L. Lang
Published 2020-08-01

Perilipin 2 downregulation in β cells impairs insulin secretion under nutritional stress and damages mitochondria

by Akansha Mishra, Siming Liu, Joseph Promes, Mikako Harata, William Sivitz, Brian Fink, Gourav Bhardwaj, Brian T. O’Neill, Chen Kang, Rajan Sah, Stefan Strack, Samuel Stephens, Timothy King, Laura Jackson, Andrew S. Greenberg, Frederick Anokye-Danso, Rexford S. Ahima, James Ankrum, Yumi Imai
Published 2021-05-01

Enhancing durability of CIS43 monoclonal antibody by Fc mutation or AAV delivery for malaria prevention

by Neville K. Kisalu, Lais D. Pereira, Keenan Ernste, Yevel Flores-Garcia, Azza H. Idris, Mangaiarkarasi Asokan, Marlon Dillon, Scott MacDonald, Wei Shi, Xuejun Chen, Amarendra Pegu, Arne Schön, Fidel Zavala, Alejandro B. Balazs, Joseph R. Francica, Robert A. Seder
Published 2021-02-01

Adverse effects of Δ9-tetrahydrocannabinol on neuronal bioenergetics during postnatal development

by Johannes Beiersdorf, Zsofia Hevesi, Daniela Calvigioni, Jakob Pyszkowski, Roman Romanov, Edit Szodorai, Gert Lubec, Sally Shirran, Catherine H. Botting, Siegfried Kasper, Geoffrey W. Guy, Roy Gray, Vincenzo Di Marzo, Tibor Harkany, Erik Keimpema
Published 2020-12-01

Obesity-induced inflammation: The impact of the hematopoietic stem cell niche

by Emily Bowers, Kanakadurga Singer
Published 2021-02-01

Characterization of quinoxaline derivatives for protection against iatrogenically induced hearing loss

by Marisa Zallocchi, Santanu Hati, Zhenhang Xu, William Hausman, Huizhan Liu, David Z. He, Jian Zuo
Published 2021-03-01

Epithelial miR-141 regulates IL-13–induced airway mucus production

by Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R. Bonser, Kyung Duk Koh, Olivier Le Tonqueze, Samaneh Bolourchi, Rodriel A. Bautista, Lorna Zlock, Theodore L. Roth, Alexander Marson, Nirav R. Bhakta, K. Mark Ansel, Walter E. Finkbeiner, David J. Erle, Prescott G. Woodruff
Published 2021-03-01

IL18-containing 5-gene signature distinguishes histologically identical dermatomyositis and lupus erythematosus skin lesions

by Lam C. Tsoi, Mehrnaz Gharaee-Kermani, Celine C. Berthier, Tori Nault, Grace A. Hile, Shannon N. Estadt, Matthew T. Patrick, Rachael Wasikowski, Allison C. Billi, Lori Lowe, Tamra J. Reed, Johann E. Gudjonsson, J. Michelle Kahlenberg
Published 2020-08-01

An immune-based biomarker signature is associated with mortality in COVID-19 patients

by Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle L. Fink, Adriana A. Almeida de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily F. Gliniewicz, Elana Shaw, Dana E. Kahle, Andre T. Rastegar, Michael Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter D. Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, NIAID COVID-19 Consortium, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S. Lionakis, Luigi D. Notarangelo
Published 2021-01-01

ORMDL3 expression in ASM regulates hypertrophy, hyperplasia via TPM1 and TPM4, and contractility

by Alexa K. Pham, Marina Miller, Peter Rosenthal, Sudipta Das, Ning Weng, Sunghoon Jang, Richard C. Kurten, Jana Badrani, Taylor A. Doherty, Brian Oliver, David H. Broide
Published 2021-04-01

Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity

by Patricia René, Damien Lanfray, Denis Richard, Michel Bouvier
Published 2021-02-01

Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver

by Max Preti, Lena Schlott, David Lübbering, Daria Krzikalla, Anna-Lena Müller, Fenja A. Schuran, Tobias Poch, Miriam Schakat, Sören Weidemann, Ansgar W. Lohse, Christina Weiler-Normann, Marcial Sebode, Dorothee Schwinge, Christoph Schramm, Antonella Carambia, Johannes Herkel
Published 2021-03-01

Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity

by Emma J. Kenyon, Nerissa K. Kirkwood, Siân R. Kitcher, Richard J. Goodyear, Marco Derudas, Daire M. Cantillon, Sarah Baxendale, Antonio de la Vega de León, Virginia N. Mahieu, Richard T. Osgood, Charlotte Donald Wilson, James C. Bull, Simon J. Waddell, Tanya T. Whitfield, Simon E. Ward, Corné J. Kros, Guy P. Richardson
Published 2021-04-01

Effective virus-neutralizing activities in antisera from the first wave of survivors of severe COVID-19

by Yang Han, Peipei Liu, Yang Qiu, Jie Zhou, Ying Liu, Xujuan Hu, Qingyu Yang, Rui Huang, Xinyue Wen, Hao Song, Pengcheng Yu, Mengjie Yang, Jing Zhang, William J. Liu, Ke Peng, Guizhen Wu, Dingyu Zhang, Xi Zhou, Ying Wu
Published 2021-02-01

Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension

by Aglaia Ntokou, Jui M. Dave, Amy C. Kauffman, Maor Sauler, Changwan Ryu, John Hwa, Erica L. Herzog, Inderjit Singh, W. Mark Saltzman, Daniel M. Greif
Published 2021-03-01

miR-122 promotes virus-induced lung disease by targeting SOCS1

by Adam M. Collison, Leon A. Sokulsky, Elizabeth Kepreotes, Ana Pereira de Siqueira, Matthew Morten, Michael R. Edwards, Ross P. Walton, Nathan W. Bartlett, Ming Yang, Thi Hiep Nguyen, Sebastian L. Johnston, Paul S. Foster, Joerg Mattes
Published 2021-04-01

Myofibroblast dedifferentiation proceeds via distinct transcriptomic and phenotypic transitions

by Sean M. Fortier, Loka R. Penke, Dana King, Tho X. Pham, Giovanni Ligresti, Marc Peters-Golden
Published 2021-03-01

PALLD mutation in a European family conveys a stromal predisposition for familial pancreatic cancer

by Lucia Liotta, Sebastian Lange, H. Carlo Maurer, Kenneth P. Olive, Rickmer Braren, Nicole Pfarr, Sebastian Burger, Alexander Muckenhuber, Moritz Jesinghaus, Katja Steiger, Wilko Weichert, Helmut Friess, Roland Schmid, Hana Algül, Philipp J. Jost, Juliane Ramser, Christine Fischer, Anne S. Quante, Maximilian Reichert, Michael Quante
Published 2021-04-01

Repurposing calcium-sensing receptor agonist cinacalcet for treatment of CFTR-mediated secretory diarrheas

by Apurva A. Oak, Parth D. Chhetri, Amber A. Rivera, Alan S. Verkman, Onur Cil
Published 2021-02-01