The Promise of Genomic Studies on Human Diseases: From Basic Science to Clinical Application

by Lam C. Tsoi, Bethany Wolf, Y. Ann Chen
Published 2017-01-01

Machine learning workflow to enhance predictions of Adverse Drug Reactions (ADRs) through drug-gene interactions: application to drugs for cutaneous diseases

by Kalpana Raja, Matthew Patrick, James T. Elder, Lam C. Tsoi
Published 2017-06-01

A Review of Recent Advancement in Integrating Omics Data with Literature Mining towards Biomedical Discoveries

by Kalpana Raja, Matthew Patrick, Yilin Gao, Desmond Madu, Yuyang Yang, Lam C. Tsoi
Published 2017-01-01

Integrative Approach to Reveal Cell Type Specificity and Gene Candidates for Psoriatic Arthritis Outside the MHC

by Matthew T. Patrick, Philip E. Stuart, Kalpana Raja, Kalpana Raja, Sunyi Chi, Sunyi Chi, Zhi He, John J. Voorhees, Trilokraj Tejasvi, Trilokraj Tejasvi, Johann E. Gudjonsson, J. Michelle Kahlenberg, Vinod Chandran, Vinod Chandran, Vinod Chandran, Vinod Chandran, Vinod Chandran, Proton Rahman, Dafna D. Gladman, Dafna D. Gladman, Dafna D. Gladman, Rajan P. Nair, James T. Elder, James T. Elder, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi
Published 2019-04-01

2D Visualization of the Psoriasis Transcriptome Fails to Support the Existence of Dual-Secreting IL-17A/IL-22 Th17 T Cells

by Stephanie T. Le, Alexander A. Merleev, Guillaume Luxardi, Michiko Shimoda, Iannis E. Adamopoulos, Lam C. Tsoi, Lam C. Tsoi, Jenny Z. Wang, Jenny Z. Wang, Claire Alexanian, Claire Alexanian, Siba P. Raychaudhuri, Siba P. Raychaudhuri, Samuel T. Hwang, Johann Gudjonsson, Alina I. Marusina, Emanual Maverakis
Published 2019-04-01

GRHL3 binding and enhancers rearrange as epidermal keratinocytes transition between functional states.

by Rachel Herndon Klein, Ziguang Lin, Amelia Soto Hopkin, William Gordon, Lam C Tsoi, Yun Liang, Johann E Gudjonsson, Bogi Andersen
Published 2017-04-01

Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis

by Richard Ahn, Richard Ahn, Damjan Vukcevic, Damjan Vukcevic, Damjan Vukcevic, Allan Motyer, Allan Motyer, Joanne Nititham, David McG. Squire, David McG. Squire, Jill A. Hollenbach, Paul J. Norman, Eva Ellinghaus, Rajan P. Nair, Lam C. Tsoi, Lam C. Tsoi, Lam C. Tsoi, Jorge Oksenberg, John Foerster, Wolfgang Lieb, Stephan Weidinger, Andre Franke, James T. Elder, James T. Elder, Eric Jorgenson, Stephen Leslie, Stephen Leslie, Stephen Leslie, Wilson Liao
Published 2021-06-01

Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

by Yanyun Jiang, Lam C. Tsoi, Allison C. Billi, Nicole L. Ward, Paul W. Harms, Chang Zeng, Emanual Maverakis, J. Michelle Kahlenberg, Johann E. Gudjonsson
Published 2020-10-01

RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature

by William R. Swindell, Maria A. Beamer, Mrinal K. Sarkar, Shannon Loftus, Joseph Fullmer, Xianying Xing, Nicole L. Ward, Lam C. Tsoi, Michelle J. Kahlenberg, Yun Liang, Johann E. Gudjonsson
Published 2018-01-01

Molecular Profiling of Cutaneous Lupus Lesions Identifies Subgroups Distinct from Clinical Phenotypes

by Celine C. Berthier, Lam C. Tsoi, Tamra J. Reed, Jasmine N. Stannard, Emily M. Myers, Rajaie Namas, Xianying Xing, Stephanie Lazar, Lori Lowe, Matthias Kretzler, Johann E. Gudjonsson, J. Michelle Kahlenberg
Published 2019-08-01

IL18-containing 5-gene signature distinguishes histologically identical dermatomyositis and lupus erythematosus skin lesions

by Lam C. Tsoi, Mehrnaz Gharaee-Kermani, Celine C. Berthier, Tori Nault, Grace A. Hile, Shannon N. Estadt, Matthew T. Patrick, Rachael Wasikowski, Allison C. Billi, Lori Lowe, Tamra J. Reed, Johann E. Gudjonsson, J. Michelle Kahlenberg
Published 2020-08-01

Correction: Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools.

by Jun Ding, Carlo Sidore, Thomas J Butler, Mary Kate Wing, Yong Qian, Osorio Meirelles, Fabio Busonero, Lam C Tsoi, Andrea Maschio, Andrea Angius, Hyun Min Kang, Ramaiah Nagaraja, Francesco Cucca, Gonçalo R Abecasis, David Schlessinger
Published 2015-09-01

Assessing Mitochondrial DNA Variation and Copy Number in Lymphocytes of ~2,000 Sardinians Using Tailored Sequencing Analysis Tools.

by Jun Ding, Carlo Sidore, Thomas J Butler, Mary Kate Wing, Yong Qian, Osorio Meirelles, Fabio Busonero, Lam C Tsoi, Andrea Maschio, Andrea Angius, Hyun Min Kang, Ramaiah Nagaraja, Francesco Cucca, Gonçalo R Abecasis, David Schlessinger
Published 2015-07-01

Epigenetic regulation of the PGE2 pathway modulates macrophage phenotype in normal and pathologic wound repair

by Frank M. Davis, Lam C. Tsoi, Rachael Wasikowski, Aaron denDekker, Amrita Joshi, Carol Wilke, Hongping Deng, Sonya Wolf, Andrea Obi, Steven Huang, Allison C. Billi, Scott Robinson, Jay Lipinski, William J. Melvin, Christopher O. Audu, Stephan Weidinger, Steven L. Kunkel, Andrew Smith, Johann E. Gudjonsson, Bethany B. Moore, Katherine A. Gallagher
Published 2020-09-01

Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients

by Matthew T. Patrick, Philip E. Stuart, Kalpana Raja, Johann E. Gudjonsson, Trilokraj Tejasvi, Jingjing Yang, Vinod Chandran, Sayantan Das, Kristina Callis-Duffin, Eva Ellinghaus, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Hyun M. Kang, Gerald G. Krueger, Henry W. Lim, Proton Rahman, Cheryl F. Rosen, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, John J. Voorhees, Gonçalo R. Abecasis, Dafna D. Gladman, Rajan P. Nair, James T. Elder, Lam C. Tsoi
Published 2018-10-01

Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study.

by Ashley Budu-Aggrey, Ben Brumpton, Jess Tyrrell, Sarah Watkins, Ellen H Modalsli, Carlos Celis-Morales, Lyn D Ferguson, Gunnhild Åberge Vie, Tom Palmer, Lars G Fritsche, Mari Løset, Jonas Bille Nielsen, Wei Zhou, Lam C Tsoi, Andrew R Wood, Samuel E Jones, Robin Beaumont, Marit Saunes, Pål Richard Romundstad, Stefan Siebert, Iain B McInnes, James T Elder, George Davey Smith, Timothy M Frayling, Bjørn Olav Åsvold, Sara J Brown, Naveed Sattar, Lavinia Paternoster
Published 2019-01-01

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants

by Lam C. Tsoi, Philip E. Stuart, Chao Tian, Johann E. Gudjonsson, Sayantan Das, Matthew Zawistowski, Eva Ellinghaus, Jonathan N. Barker, Vinod Chandran, Nick Dand, Kristina Callis Duffin, Charlotta Enerbäck, Tõnu Esko, Andre Franke, Dafna D. Gladman, Per Hoffmann, Külli Kingo, Sulev Kõks, Gerald G. Krueger, Henry W. Lim, Andres Metspalu, Ulrich Mrowietz, Sören Mucha, Proton Rahman, Andre Reis, Trilokraj Tejasvi, Richard Trembath, John J. Voorhees, Stephan Weidinger, Michael Weichenthal, Xiaoquan Wen, Nicholas Eriksson, Hyun M. Kang, David A. Hinds, Rajan P. Nair, Gonçalo R. Abecasis, James T Elder
Published 2017-05-01

Contribution of plasma cells and B cells to hidradenitis suppurativa pathogenesis

by Johann E. Gudjonsson, Lam C. Tsoi, Feiyang Ma, Allison C. Billi, K.R. van Straalen, A.R.J.V. Vossen, H.H. van der Zee, Paul W. Harms, Rachael Wasikowski, Christine M. Yee, Syed M. Rizvi, Xianying Xing, Enze Xing, Olesya Plazyo, Chang Zeng, Matthew T. Patrick, Margaret M. Lowe, Richard E. Burney, Jeffrey H. Kozlow, Jill R. Cherry-Bukowiec, Yanyun Jiang, Joseph Kirma, Stephan Weidinger, Kelly C. Cushing, Michael D. Rosenblum, Celine Berthier, Amanda S. MacLeod, John J. Voorhees, Fei Wen, J. Michelle Kahlenberg, Emanual Maverakis, Robert L. Modlin, Errol P. Prens
Published 2020-10-01

Neutrophil Subsets, Platelets, and Vascular Disease in Psoriasis

by Heather L. Teague, PhD, Nevin J. Varghese, BS, Lam C. Tsoi, PhD, Amit K. Dey, MD, Michael S. Garshick, MD, Joanna I. Silverman, BA, Yvonne Baumer, PhD, Charlotte L. Harrington, BA, Erin Stempinski, MS, Youssef A. Elnabawi, BS, Pradeep K. Dagur, PhD, Kairong Cui, PhD, Ilker Tunc, PhD, Fayaz Seifuddin, MSc, Aditya A. Joshi, MD, Elena Stansky, BS, Monica M. Purmalek, BS, Justin A. Rodante, PA, Andrew Keel, DNP, Tarek Z. Aridi, BS, Carmelo Carmona-Rivera, PhD, Gregory E. Sanda, BS, Marcus Y. Chen, MD, Mehdi Pirooznia, MD, PhD, J. Philip McCoy, Jr., PhD, Joel M. Gelfand, MD, Keji Zhao, PhD, Johann E. Gudjonsson, MD, PhD, Martin P. Playford, PhD, Mariana J. Kaplan, MD, Jeffrey S. Berger, MD, Nehal N. Mehta, MD
Published 2019-02-01

Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study.

by Bram P Prins, Ali Abbasi, Anson Wong, Ahmad Vaez, Ilja Nolte, Nora Franceschini, Philip E Stuart, Javier Guterriez Achury, Vanisha Mistry, Jonathan P Bradfield, Ana M Valdes, Jose Bras, Aleksey Shatunov, PAGE Consortium, International Stroke Genetics Consortium, Systemic Sclerosis consortium, Treat OA consortium, DIAGRAM Consortium, CARDIoGRAMplusC4D Consortium, ALS consortium, International Parkinson’s Disease Genomics Consortium, Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, CKDGen consortium, GERAD1 Consortium, International Consortium for Blood Pressure, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Inflammation Working Group of the CHARGE Consortium, Chen Lu, Buhm Han, Soumya Raychaudhuri, Steve Bevan, Maureen D Mayes, Lam C Tsoi, Evangelos Evangelou, Rajan P Nair, Struan F A Grant, Constantin Polychronakos, Timothy R D Radstake, David A van Heel, Melanie L Dunstan, Nicholas W Wood, Ammar Al-Chalabi, Abbas Dehghan, Hakon Hakonarson, Hugh S Markus, James T Elder, Jo Knight, Dan E Arking, Timothy D Spector, Bobby P C Koeleman, Cornelia M van Duijn, Javier Martin, Andrew P Morris, Rinse K Weersma, Cisca Wijmenga, Patricia B Munroe, John R B Perry, Jennie G Pouget, Yalda Jamshidi, Harold Snieder, Behrooz Z Alizadeh
Published 2016-06-01