The C allele of rs5743836 polymorphism in the human TLR9 promoter links IL-6 and TLR9 up-regulation and confers increased B-cell proliferation.

by Agostinho Carvalho, Nuno S Osório, Margarida Saraiva, Cristina Cunha, Agostinho J Almeida, Maria Teixeira-Coelho, Paula Ludovico, Jorge Pedrosa, Lucia Pitzurra, Franco Aversa, Luigina Romani, António G Castro, Fernando Rodrigues
Published 2011-01-01

IL-22 and IDO1 affect immunity and tolerance to murine and human vaginal candidiasis.

by Antonella De Luca, Agostinho Carvalho, Cristina Cunha, Rossana G Iannitti, Lucia Pitzurra, Gloria Giovannini, Antonella Mencacci, Lorenzo Bartolommei, Silvia Moretti, Cristina Massi-Benedetti, Dietmar Fuchs, Flavia De Bernardis, Paolo Puccetti, Luigina Romani
Published 2013-01-01

TLR9 activation dampens the early inflammatory response to Paracoccidioides brasiliensis, impacting host survival.

by João Filipe Menino, Margarida Saraiva, Ana G Gomes-Alves, Diogo Lobo-Silva, Mark Sturme, Jéssica Gomes-Rezende, Ana Laura Saraiva, Gustavo H Goldman, Cristina Cunha, Agostinho Carvalho, Luigina Romani, Jorge Pedrosa, António Gil Castro, Fernando Rodrigues
Published 2013-01-01

Impact of Paracoccin Gene Silencing on Paracoccidioides brasiliensis Virulence

by Fabrício F. Fernandes, Aline F. Oliveira, Taise N. Landgraf, Cristina Cunha, Agostinho Carvalho, Patríícia E. Vendruscolo, Relber A. Goncales, Fausto Almeida, Thiago A. da Silva, Fernando Rodrigues, Maria Cristina Roque-Barreira, Christina A. Cuomo, Antonio Cassone
Published 2017-07-01

Common genetic polymorphisms within NFκB-related genes and the risk of developing invasive aspergillosis

by Carmen Belén Lupiañez, Carmen Belén Lupiañez, María Teresa Villaescusa, María Teresa Villaescusa, Agostinho Carvalho, Agostinho Carvalho, Jan Springer, Michaela Lackner, José Manuel Sánchez-Maldonado, Luz María Canet, Cristina Cunha, Juana Segura-Catena, Juana Segura-Catena, Laura Alcazar-Fuoli, Carlos Solano, Luana Fianchi, Livio Pagano, Leonardo Potenza, José María Aguado, Mario Luppi, Manuel Cuenca-Estrella, Cornelia Lass-Flörl, Hermann Einsele, Lourdes Vázquez, PCRAGA Study Group, Rafael Ríos-Tamayo, Rafael Ríos-Tamayo, Jurgen Loeffler, Manuel Jurado, Manuel Jurado, Juan Sainz, Juan Sainz
Published 2016-08-01

Fungal and host protein persulfidation are functionally correlated and modulate both virulence and antifungal response.

by Monica Sueiro-Olivares, Jennifer Scott, Sara Gago, Dunja Petrovic, Emilia Kouroussis, Jasmina Zivanovic, Yidong Yu, Marlene Strobel, Cristina Cunha, Darren Thomson, Rachael Fortune-Grant, Sina Thusek, Paul Bowyer, Andreas Beilhack, Agostinho Carvalho, Elaine Bignell, Milos R Filipovic, Jorge Amich
Published 2021-06-01

Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways

by Mariolina Bruno, Intan M.W. Dewi, Vicky Matzaraki, Rob ter Horst, Marina Pekmezovic, Berenice Rösler, Laszlo Groh, Rutger J. Röring, Vinod Kumar, Yang Li, Agostinho Carvalho, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Published 2021-01-01

The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

by Inês Mesquita, Carolina Ferreira, Diana Moreira, George Eduardo Gabriel Kluck, Ana Margarida Barbosa, Egídio Torrado, Ricardo Jorge Dinis-Oliveira, Luís Gafeira Gonçalves, Charles-Joly Beauparlant, Arnaud Droit, Luciana Berod, Tim Sparwasser, Neelam Bodhale, Bhaskar Saha, Fernando Rodrigues, Cristina Cunha, Agostinho Carvalho, António Gil Castro, Jérôme Estaquier, Ricardo Silvestre
Published 2020-03-01

Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus

by Andrea Doni, Raffaella Parente, Ilaria Laface, Elena Magrini, Cristina Cunha, Federico Simone Colombo, João F. Lacerda, António Campos, Sarah N. Mapelli, Francesca Petroni, Rémi Porte, Tilo Schorn, Antonio Inforzato, Toine Mercier, Katrien Lagrou, Johan Maertens, John D. Lambris, Barbara Bottazzi, Cecilia Garlanda, Marina Botto, Agostinho Carvalho, Alberto Mantovani
Published 2021-06-01

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

by Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos, Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdonk
Published 2018-07-01

Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis

by Intan M.W. Dewi, Cristina Cunha, Martin Jaeger, Mark S. Gresnigt, Marina E. Gkountzinopoulou, Fadel M. Garishah, Cláudio Duarte-Oliveira, Cláudia F. Campos, Lore Vanderbeke, Agustin Resendiz Sharpe, Roger J. Brüggemann, Paul E. Verweij, Katrien Lagrou, Greetje Vande Velde, Quirijn de Mast, Leo A.B. Joosten, Mihai G. Netea, Andre J.A.M. van der Ven, Joost Wauters, Agostinho Carvalho, Frank L. van de Veerdonk
Published 2021-05-01

Characterization of specific immune responses to different Aspergillus antigens during the course of invasive Aspergillosis in hematologic patients.

by Leonardo Potenza, Daniela Vallerini, Patrizia Barozzi, Giovanni Riva, Fabio Forghieri, Anne Beauvais, Remi Beau, Anna Candoni, Johan Maertens, Giulio Rossi, Giulio Rossi, Monica Morselli, Eleonora Zanetti, Chiara Quadrelli, Mauro Codeluppi, Giovanni Guaraldi, Livio Pagano, Morena Caira, Cinzia Del Giovane, Monica Maccaferri, Alessandro Stefani, Uliano Morandi, Giovanni Tazzioli, Massimo Girardis, Mario Delia, Giorgina Specchia, Giuseppe Longo, Roberto Marasca, Franco Narni, Francesco Merli, Annalisa Imovilli, Giovanni Apolone, Agostinho Carvalho, Patrizia Comoli, Luigina Romani, Jean Paul Latgè, Mario Luppi
Published 2013-01-01

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

by Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Cláudia F. Campos, Vishukumar Aimanianda, Rob ter Horst, Luis Leite, Toine Mercier, Paulo Pereira, Miguel Fernández-García, Daniela Antunes, Cláudia S. Rodrigues, Catarina Barbosa-Matos, Joana Gaifem, Inês Mesquita, António Marques, Nuno S. Osório, Egídio Torrado, Fernando Rodrigues, Sandra Costa, Leo AB. Joosten, Katrien Lagrou, Johan Maertens, João F. Lacerda, António Campos, Gordon D. Brown, Axel A. Brakhage, Coral Barbas, Ricardo Silvestre, Frank L. van de Veerdonk, Georgios Chamilos, Mihai G. Netea, Jean-Paul Latgé, Cristina Cunha, Agostinho Carvalho
Published 2020-05-01

Polymorphisms within the <i>TNFSF4</i> and <i>MAPKAPK2</i> Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIO...

by Jose Manuel Sánchez-Maldonado, Ana Moñiz-Díez, Rob ter Horst, Daniele Campa, Antonio José Cabrera-Serrano, Manuel Martínez-Bueno, María del Pilar Garrido-Collado, Francisca Hernández-Mohedo, Laura Fernández-Puerta, Miguel Ángel López-Nevot, Cristina Cunha, Pedro Antonio González-Sierra, Jan Springer, Michaela Lackner, Laura Alcazar-Fuoli, Luana Fianchi, José María Aguado, Livio Pagano, Elisa López-Fernández, Esther Clavero, Leonardo Potenza, Mario Luppi, Lucia Moratalla, Carlos Solano, Antonio Sampedro, Manuel Cuenca-Estrella, Cornelia Lass-Flörl, Federico Canzian, Juergen Loeffler, Yang Li, Hermann Einsele, Mihai G. Netea, Lourdes Vázquez, Agostinho Carvalho, Manuel Jurado, Juan Sainz, on behalf of the PCRAGA Study Group
Published 2021-12-01