Robustness and applicability of transcription factor and pathway analysis tools on single-cell RNA-seq data

by Christian H. Holland, Jovan Tanevski, Javier Perales-Patón, Jan Gleixner, Manu P. Kumar, Elisabetta Mereu, Brian A. Joughin, Oliver Stegle, Douglas A. Lauffenburger, Holger Heyn, Bence Szalai, Julio Saez-Rodriguez
Published 2020-02-01

Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.

by Dequina Nicholas, Elizabeth A Proctor, Forum M Raval, Blanche C Ip, Chloe Habib, Eleni Ritou, Tom N Grammatopoulos, Devin Steenkamp, Hans Dooms, Caroline M Apovian, Douglas A Lauffenburger, Barbara S Nikolajczyk
Published 2017-01-01

The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile.

by Jesse Lyons, Phaedra C Ghazi, Alina Starchenko, Alessio Tovaglieri, Katherine R Baldwin, Emily J Poulin, Jessica J Gierut, Casie Genetti, Vijay Yajnik, David T Breault, Douglas A Lauffenburger, Kevin M Haigis
Published 2018-03-01

Antibody Subclass and Glycosylation Shift Following Effective TB Treatment

by Patricia S. Grace, Patricia S. Grace, Sepideh Dolatshahi, Lenette L. Lu, Adam Cain, Fabrizio Palmieri, Linda Petrone, Sarah M. Fortune, Tom H. M. Ottenhoff, Douglas A. Lauffenburger, Delia Goletti, Simone A. Joosten, Galit Alter
Published 2021-07-01

Multivariate Computational Analysis of Gamma Delta T Cell Inhibitory Receptor Signatures Reveals the Divergence of Healthy and ART-Suppressed HIV+ Aging

by Anna C. Belkina, Anna C. Belkina, Alina Starchenko, Katherine A. Drake, Elizabeth A. Proctor, Riley M. F. Pihl, Alex Olson, Douglas A. Lauffenburger, Nina Lin, Jennifer E. Snyder-Cappione, Jennifer E. Snyder-Cappione
Published 2018-12-01

Hepatic Dysfunction Caused by Consumption of a High-Fat Diet

by Anthony R. Soltis, Norman J. Kennedy, Xiaofeng Xin, Feng Zhou, Scott B. Ficarro, Yoon Sing Yap, Bryan J. Matthews, Douglas A. Lauffenburger, Forest M. White, Jarrod A. Marto, Roger J. Davis, Ernest Fraenkel
Published 2017-12-01

Exploiting glycan topography for computational design of Env glycoprotein antigenicity.

by Wen-Han Yu, Peng Zhao, Monia Draghi, Claudia Arevalo, Christina B Karsten, Todd J Suscovich, Bronwyn Gunn, Hendrik Streeck, Abraham L Brass, Michael Tiemeyer, Michael Seaman, John R Mascola, Lance Wells, Douglas A Lauffenburger, Galit Alter
Published 2018-04-01

A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis

by Stephanie Fischinger, Stephanie Fischinger, Deniz Cizmeci, Deniz Cizmeci, Sally Shin, Leela Davies, Patricia S. Grace, Aida Sivro, Aida Sivro, Nonhlanhla Yende-Zuma, Nonhlanhla Yende-Zuma, Hendrik Streeck, Sarah M. Fortune, Sarah M. Fortune, Douglas A. Lauffenburger, Kogieleum Naidoo, Kogieleum Naidoo, Galit Alter
Published 2021-09-01

Mining for humoral correlates of HIV control and latent reservoir size.

by Jishnu Das, Anush Devadhasan, Caitlyn Linde, Tom Broge, Jessica Sassic, Max Mangano, Sean O'Keefe, Todd Suscovich, Hendrik Streeck, Alivelu Irrinki, Chris Pohlmeyer, Gundula Min-Oo, Shu Lin, Joshua A Weiner, Thomas Cihlar, Margaret E Ackerman, Boris Julg, Steven Deeks, Douglas A Lauffenburger, Galit Alter
Published 2020-10-01

Discrete SARS-CoV-2 antibody titers track with functional humoral stability

by Yannic C. Bartsch, Stephanie Fischinger, Sameed M. Siddiqui, Zhilin Chen, Jingyou Yu, Makda Gebre, Caroline Atyeo, Matthew J. Gorman, Alex Lee Zhu, Jaewon Kang, John S. Burke, Matthew Slein, Matthew J. Gluck, Samuel Beger, Yiyuan Hu, Justin Rhee, Eric Petersen, Benjamin Mormann, Michael de St Aubin, Mohammad A. Hasdianda, Guruprasad Jambaulikar, Edward W. Boyer, Pardis C. Sabeti, Dan H. Barouch, Boris D. Julg, Elon R. Musk, Anil S. Menon, Douglas A. Lauffenburger, Eric J. Nilles, Galit Alter
Published 2021-02-01

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

by Elizabeth C. Randall, Kristina B. Emdal, Janice K. Laramy, Minjee Kim, Alison Roos, David Calligaris, Michael S. Regan, Shiv K. Gupta, Ann C. Mladek, Brett L. Carlson, Aaron J. Johnson, Fa-Ke Lu, X. Sunney Xie, Brian A. Joughin, Raven J. Reddy, Sen Peng, Walid M. Abdelmoula, Pamela R. Jackson, Aarti Kolluri, Katherine A. Kellersberger, Jeffrey N. Agar, Douglas A. Lauffenburger, Kristin R. Swanson, Nhan L. Tran, William F. Elmquist, Forest M. White, Jann N. Sarkaria, Nathalie Y. R. Agar
Published 2018-11-01

Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination

by Matthew J. Gorman, Nita Patel, Mimi Guebre-Xabier, Alex L. Zhu, Caroline Atyeo, Krista M. Pullen, Carolin Loos, Yenny Goez-Gazi, Ricardo Carrion, Jr., Jing-Hui Tian, Dansu Yuan, Kathryn A. Bowman, Bin Zhou, Sonia Maciejewski, Marisa E. McGrath, James Logue, Matthew B. Frieman, David Montefiori, Colin Mann, Sharon Schendel, Fatima Amanat, Florian Krammer, Erica Ollmann Saphire, Douglas A. Lauffenburger, Ann M. Greene, Alyse D. Portnoff, Michael J. Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Galit Alter
Published 2021-09-01

Computational analysis of cell-cell communication in the tumor microenvironment

by Kumar, Manu Prajapati.
Published 2019

Macrophage-mediated resistance mechanisms against MAPK inhibitory by cancer therapeutics

by Wang, Stephanie Joy.
Published 2019

Regulation of integrin-mediated linkages during cell migration

by Palecek, Sean Paul
Published 2010

Tau aggregation is heterogeneous across cases of sporadic Alzheimer's disease and is influenced by autophagy pathways in vitro

by Kamath, Tarun(Tarun Vinod)
Published 2020

Quantitative analysis of the T cell receptor signaling network in response to altered peptide ligands

by Wille, Lucia
Published 2006

Development and analysis of an in vitro model of inflammatory cytokine-mediated idiosyncratic drug hepatotoxicity

by Hasan, Maya
Published 2008

Cellular compartmentation effects in receptor-mediated signal transduction

by Haugh, Jason Michael, 1972-
Published 2014

Quantification of receptor-ligand interactions on bioengineered autocrine call system : a comparision of theory and experiments

by Oehrtman, Gregory Todd
Published 2009