Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause

by Rui Fan, Yung Su Kim, Jie Wu, Rui Chen, Dagmar Zeuschner, Karina Mildner, Kenjiro Adachi, Guangming Wu, Styliani Galatidou, Jianhua Li, Hans R. Schöler, Sebastian A. Leidel, Ivan Bedzhov
Published 2020-10-01

Direct Conversion of Mouse Fibroblasts into Cholangiocyte Progenitor Cells

by Kyung Tae Lim, Jonghun Kim, Seon In Hwang, Ludi Zhang, Heonjong Han, Dasom Bae, Kee-Pyo Kim, Yi-Ping Hu, Hans R. Schöler, Insuk Lee, Lijian Hui, Dong Wook Han
Published 2018-05-01

Cell-Type-Specific High Throughput Toxicity Testing in Human Midbrain Organoids

by Henrik Renner, Katharina J. Becker, Katharina J. Becker, Theresa E. Kagermeier, Theresa E. Kagermeier, Martha Grabos, Farsam Eliat, Farsam Eliat, Patrick Günther, Patrick Günther, Hans R. Schöler, Jan M. Bruder
Published 2021-07-01

Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model

by Hyunah Lee, Hye Yeong Lee, Byeong Eun Lee, Daniela Gerovska, Soo Yong Park, Holm Zaehres, Marcos J Araúzo-Bravo, Jae-Ick Kim, Yoon Ha, Hans R Schöler, Jeong Beom Kim
Published 2020-06-01

Comparative transcriptome analysis in induced neural stem cells reveals defined neural cell identities in vitro and after transplantation into the adult rodent brain

by Anna-Lena Hallmann, Marcos J. Araúzo-Bravo, Christina Zerfass, Volker Senner, Marc Ehrlich, Olympia E. Psathaki, Dong Wook Han, Natalia Tapia, Holm Zaehres, Hans R. Schöler, Tanja Kuhlmann, Gunnar Hargus
Published 2016-05-01

Blockage of the Epithelial-to-Mesenchymal Transition Is Required for Embryonic Stem Cell Derivation

by Mehdi Totonchi, Seyedeh-Nafiseh Hassani, Ali Sharifi-Zarchi, Natalia Tapia, Kenjiro Adachi, Julia Arand, Boris Greber, Davood Sabour, Marcos J. Araúzo-Bravo, Jörn Walter, Mohammad Pakzad, Hamid Gourabi, Hans R. Schöler, Hossein Baharvand
Published 2017-10-01

Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model.

by Myung Rae Park, Man Sze Wong, Marcos J Araúzo-Bravo, Hyunah Lee, Donggyu Nam, Soo Yong Park, Hong Dae Seo, Sang Min Lee, Hans Florian Zeilhofer, Holm Zaehres, Hans R Schöler, Jeong Beom Kim
Published 2019-01-01

GAA Deficiency in Pompe Disease Is Alleviated by Exon Inclusion in iPSC-Derived Skeletal Muscle Cells

by Erik van der Wal, Atze J. Bergsma, Tom J.M. van Gestel, Stijn L.M. in ‘t Groen, Holm Zaehres, Marcos J. Araúzo-Bravo, Hans R. Schöler, Ans T. van der Ploeg, W.W.M. Pim Pijnappel
Published 2017-06-01

Germ cell nuclear factor regulates gametogenesis in developing gonads.

by Davood Sabour, Xueping Xu, Arthur C K Chung, Damien Le Menuet, Kinarm Ko, Natalia Tapia, Marcos J Araúzo-Bravo, Luca Gentile, Boris Greber, Karin Hübner, Vittorio Sebastiano, Guangming Wu, Hans R Schöler, Austin J Cooney
Published 2014-01-01

Fusion of Reprogramming Factors Alters the Trajectory of Somatic Lineage Conversion

by Sergiy Velychko, Kyuree Kang, Sung Min Kim, Tae Hwan Kwak, Kee-Pyo Kim, Chanhyeok Park, Kwonho Hong, ChiHye Chung, Jung Keun Hyun, Caitlin M. MacCarthy, Guangming Wu, Hans R. Schöler, Dong Wook Han
Published 2019-04-01

Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells.

by Guangming Wu, Na Liu, Ina Rittelmeyer, Amar Deep Sharma, Malte Sgodda, Holm Zaehres, Martina Bleidissel, Boris Greber, Luca Gentile, Dong Wook Han, Cornelia Rudolph, Doris Steinemann, Axel Schambach, Michael Ott, Hans R Schöler, Tobias Cantz
Published 2011-07-01

A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids

by Henrik Renner, Martha Grabos, Katharina J Becker, Theresa E Kagermeier, Jie Wu, Mandy Otto, Stefan Peischard, Dagmar Zeuschner, Yaroslav TsyTsyura, Paul Disse, Jürgen Klingauf, Sebastian A Leidel, Guiscard Seebohm, Hans R Schöler, Jan M Bruder
Published 2020-11-01

Genome-wide tracking of dCas9-methyltransferase footprints

by Christina Galonska, Jocelyn Charlton, Alexandra L. Mattei, Julie Donaghey, Kendell Clement, Hongcang Gu, Arman W. Mohammad, Elena K. Stamenova, Davide Cacchiarelli, Sven Klages, Bernd Timmermann, Tobias Cantz, Hans R. Schöler, Andreas Gnirke, Michael J. Ziller, Alexander Meissner
Published 2018-02-01

Correction: Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

by Peter Reinhardt, Michael Glatza, Kathrin Hemmer, Yaroslav Tsytsyura, Cora S. Thiel, Susanne Höing, Sören Moritz, Juan A. Parga, Lydia Wagner, Jan M. Bruder, Guangming Wu, Benjamin Schmid, Albrecht Röpke, Jürgen Klingauf, Jens C. Schwamborn, Thomas Gasser, Hans R. Schöler, Jared Sterneckert
Published 2013-01-01

Correction: Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling.

by Peter Reinhardt, Michael Glatza, Kathrin Hemmer, Yaroslav Tsytsyura, Cora S. Thiel, Susanne Höing, Sören Moritz, Juan A. Parga, Lydia Wagner, Jan M. Bruder, Guangming Wu, Benjamin Schmid, Albrecht Röpke, Jürgen Klingauf, Jens C. Schwamborn, Thomas Gasser, Hans R. Schöler, Jared Sterneckert
Published 2013-01-01

Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.

by Peter Reinhardt, Michael Glatza, Kathrin Hemmer, Yaroslav Tsytsyura, Cora S Thiel, Susanne Höing, Sören Moritz, Juan A Parga, Lydia Wagner, Jan M Bruder, Guangming Wu, Benjamin Schmid, Albrecht Röpke, Jürgen Klingauf, Jens C Schwamborn, Thomas Gasser, Hans R Schöler, Jared Sterneckert
Published 2013-01-01

Pluripotency reprogramming by competent and incompetent POU factors uncovers temporal dependency for Oct4 and Sox2

by Vikas Malik, Laura V. Glaser, Dennis Zimmer, Sergiy Velychko, Mingxi Weng, Markus Holzner, Marius Arend, Yanpu Chen, Yogesh Srivastava, Veeramohan Veerapandian, Zahir Shah, Miguel A. Esteban, Huating Wang, Jiekai Chen, Hans R. Schöler, Andrew P. Hutchins, Sebastiaan H. Meijsing, Sebastian Pott, Ralf Jauch
Published 2019-08-01

Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis

by Gemma Gomez-Giro, Jonathan Arias-Fuenzalida, Javier Jarazo, Dagmar Zeuschner, Muhammad Ali, Nina Possemis, Silvia Bolognin, Rashi Halder, Christian Jäger, Willemijn F. E. Kuper, Peter M. van Hasselt, Holm Zaehres, Antonio del Sol, Herman van der Putten, Hans R. Schöler, Jens C. Schwamborn
Published 2019-12-01

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein

by Marc Ehrlich, Anna-Lena Hallmann, Peter Reinhardt, Marcos J. Araúzo-Bravo, Sabrina Korr, Albrecht Röpke, Olympia E. Psathaki, Petra Ehling, Sven G. Meuth, Adrian L. Oblak, Jill R. Murrell, Bernardino Ghetti, Holm Zaehres, Hans R. Schöler, Jared Sterneckert, Tanja Kuhlmann, Gunnar Hargus
Published 2015-07-01

A Dynamic Role of TBX3 in the Pluripotency Circuitry

by Ronan Russell, Marcus Ilg, Qiong Lin, Guangming Wu, André Lechel, Wendy Bergmann, Tim Eiseler, Leonhard Linta, Pavan Kumar P., Moritz Klingenstein, Kenjiro Adachi, Meike Hohwieler, Olena Sakk, Stefanie Raab, Anne Moon, Martin Zenke, Thomas Seufferlein, Hans R. Schöler, Anett Illing, Stefan Liebau, Alexander Kleger
Published 2015-12-01