Deep sequencing of the Nicastrin gene in pooled DNA, the identification of genetic variants that affect risk of Alzheimer's disease.

by Michelle K Lupton, Petroula Proitsi, Makrina Danillidou, Magda Tsolaki, Gillian Hamilton, Richard Wroe, Megan Pritchard, Kathryn Lord, Belinda M Martin, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Denise Harold, Paul Hollingworth, Simon Lovestone, John F Powell
Published 2011-02-01

Pooling individual participant data from randomized controlled trials: Exploring potential loss of information.

by Lennard L van Wanrooij, Marieke P Hoevenaar-Blom, Nicola Coley, Tiia Ngandu, Yannick Meiller, Juliette Guillemont, Anna Rosenberg, Cathrien R L Beishuizen, Eric P Moll van Charante, Hilkka Soininen, Carol Brayne, Sandrine Andrieu, Miia Kivipelto, Edo Richard
Published 2020-01-01

Genetic loci associated with Alzheimer's disease and cerebrospinal fluid biomarkers in a Finnish case-control cohort.

by Lyzel S Elias-Sonnenschein, Seppo Helisalmi, Teemu Natunen, Anette Hall, Teemu Paajanen, Sanna-Kaisa Herukka, Marjo Laitinen, Anne M Remes, Anne M Koivisto, Kari M Mattila, Terho Lehtimäki, Frans R J Verhey, Pieter Jelle Visser, Hilkka Soininen, Mikko Hiltunen
Published 2013-01-01

Recruitment and Baseline Characteristics of Participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)—A Randomized Controlled...

by Tiia Ngandu, Jenni Lehtisalo, Esko Levälahti, Tiina Laatikainen, Jaana Lindström, Markku Peltonen, Alina Solomon, Satu Ahtiluoto, Riitta Antikainen, Tuomo Hänninen, Antti Jula, Francesca Mangialasche, Teemu Paajanen, Satu Pajala, Rainer Rauramaa, Timo Strandberg, Jaakko Tuomilehto, Hilkka Soininen, Miia Kivipelto
Published 2014-09-01

Brain volumes and cortical thickness on MRI in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)

by Ruth Stephen, Yawu Liu, Tiia Ngandu, Riitta Antikainen, Juha Hulkkonen, Juha Koikkalainen, Nina Kemppainen, Jyrki Lötjönen, Esko Levälahti, Riitta Parkkola, Pauliina Pippola, Juha Rinne, Timo Strandberg, Jaakko Tuomilehto, Ritva Vanninen, Miia Kivipelto, Hilkka Soininen, Alina Solomon, for the FINGER study group
Published 2019-06-01

Plasma biomarkers of brain atrophy in Alzheimer's disease.

by Madhav Thambisetty, Andrew Simmons, Abdul Hye, James Campbell, Eric Westman, Yi Zhang, Lars-Olof Wahlund, Anna Kinsey, Mirsada Causevic, Richard Killick, Iwona Kloszewska, Patrizia Mecocci, Hilkka Soininen, Magda Tsolaki, Bruno Vellas, Christian Spenger, Simon Lovestone, AddNeuroMed Consortium
Published 2011-01-01

Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia.

by Sarah Jesse, Stefan Lehnert, Olaf Jahn, Lucilla Parnetti, Hilkka Soininen, Sanna-Kaisa Herukka, Petra Steinacker, Saskia Tawfik, Hayrettin Tumani, Christine A F von Arnim, Manuela Neumann, Hans A Kretzschmar, Hasan Kulaksiz, Martin Lenter, Jens Wiltfang, Boris Ferger, Bastian Hengerer, Markus Otto
Published 2012-01-01

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death

by Henna Martiskainen, Kaisa M. A. Paldanius, Teemu Natunen, Mari Takalo, Mikael Marttinen, Stina Leskelä, Nadine Huber, Petra Mäkinen, Enni Bertling, Hiramani Dhungana, Mikko Huuskonen, Paavo Honkakoski, Pirta Hotulainen, Kirsi Rilla, Jari Koistinaho, Hilkka Soininen, Tarja Malm, Annakaisa Haapasalo, Mikko Hiltunen
Published 2017-11-01

Differential diagnosis of neurodegenerative diseases using structural MRI data

by Juha Koikkalainen, Hanneke Rhodius-Meester, Antti Tolonen, Frederik Barkhof, Betty Tijms, Afina W. Lemstra, Tong Tong, Ricardo Guerrero, Andreas Schuh, Christian Ledig, Daniel Rueckert, Hilkka Soininen, Anne M. Remes, Gunhild Waldemar, Steen Hasselbalch, Patrizia Mecocci, Wiesje van der Flier, Jyrki Lötjönen
Published 2016-01-01

The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer’s pathology

by Sarah Westwood, Benjamine Liu, Alison L. Baird, Sneha Anand, Alejo J. Nevado-Holgado, Danielle Newby, Maria Pikkarainen, Merja Hallikainen, Johanna Kuusisto, Johannes R. Streffer, Gerald Novak, Kaj Blennow, Ulf Andreasson, Henrik Zetterberg, Ulf Smith, Markku Laakso, Hilkka Soininen, Simon Lovestone
Published 2017-04-01

Selection of memory clinic patients for CSF biomarker assessment can be restricted to a quarter of cases by using computerized decision support, without compromising diagnostic acc...

by Hanneke F M Rhodius-Meester, Ingrid S van Maurik, Juha Koikkalainen, Antti Tolonen, Kristian S Frederiksen, Steen G Hasselbalch, Hilkka Soininen, Sanna-Kaisa Herukka, Anne M Remes, Charlotte E Teunissen, Frederik Barkhof, Yolande A L Pijnenburg, Philip Scheltens, Jyrki Lötjönen, Wiesje M van der Flier
Published 2020-01-01

Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a Mendelian randomization analysis.

by Petroula Proitsi, Michelle K Lupton, Latha Velayudhan, Stephen Newhouse, Isabella Fogh, Magda Tsolaki, Makrina Daniilidou, Megan Pritchard, Iwona Kloszewska, Hilkka Soininen, Patrizia Mecocci, Bruno Vellas, Alzheimer's Disease Neuroimaging Initiative, Julie Williams, GERAD1 Consortium, Robert Stewart, Pak Sham, Simon Lovestone, John F Powell
Published 2014-09-01

Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis

by Antti Cajanus, Anette Hall, Juha Koikkalainen, Eino Solje, Antti Tolonen, Timo Urhemaa, Yawu Liu, Ramona M. Haanpää, Päivi Hartikainen, Seppo Helisalmi, Ville Korhonen, Daniel Rueckert, Steen Hasselbalch, Gunhild Waldemar, Patrizia Mecocci, Ritva Vanninen, Mark van Gils, Hilkka Soininen, Jyrki Lötjönen, Anne M. Remes
Published 2018-02-01

Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer’s...

by Luke Whiley, Katie E. Chappell, Ellie D’Hondt, Matthew R. Lewis, Beatriz Jiménez, Stuart G. Snowden, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Jonathan R. Swann, Abdul Hye, Simon Lovestone, Cristina Legido-Quigley, Elaine Holmes, on behalf of AddNeuroMed consortium
Published 2021-01-01

Five-class differential diagnostics of neurodegenerative diseases using random undersampling boosting

by Tong Tong, Christian Ledig, Ricardo Guerrero, Andreas Schuh, Juha Koikkalainen, Antti Tolonen, Hanneke Rhodius, Frederik Barkhof, Betty Tijms, Afina W Lemstra, Hilkka Soininen, Anne M Remes, Gunhild Waldemar, Steen Hasselbalch, Patrizia Mecocci, Marta Baroni, Jyrki Lötjönen, Wiesje van der Flier, Daniel Rueckert
Published 2017-01-01

Detecting frontotemporal dementia syndromes using MRI biomarkers

by Marie Bruun, Juha Koikkalainen, Hanneke F.M. Rhodius-Meester, Marta Baroni, Le Gjerum, Mark van Gils, Hilkka Soininen, Anne M. Remes, Päivi Hartikainen, Gunhild Waldemar, Patrizia Mecocci, Frederik Barkhof, Yolande Pijnenburg, Wiesje M. van der Flier, Steen G. Hasselbalch, Jyrki Lötjönen, Kristian S. Frederiksen
Published 2019-01-01

Plasma based markers of [11C] PiB-PET brain amyloid burden.

by Steven John Kiddle, Madhav Thambisetty, Andrew Simmons, Joanna Riddoch-Contreras, Abdul Hye, Eric Westman, Ian Pike, Malcolm Ward, Caroline Johnston, Michelle Katharine Lupton, Katie Lunnon, Hilkka Soininen, Iwona Kloszewska, Magda Tsolaki, Bruno Vellas, Patrizia Mecocci, Simon Lovestone, Stephen Newhouse, Richard Dobson, Alzheimers Disease Neuroimaging Initiative
Published 2012-01-01

Diabetes is associated with familial idiopathic normal pressure hydrocephalus: a case–control comparison with family members

by Joel Räsänen, Joel Huovinen, Ville E. Korhonen, Antti Junkkari, Sami Kastinen, Simo Komulainen, Minna Oinas, Cecilia Avellan, Janek Frantzen, Jaakko Rinne, Antti Ronkainen, Mikko Kauppinen, Kimmo Lönnrot, Markus Perola, Anne M. Koivisto, Anne M. Remes, Hilkka Soininen, Mikko Hiltunen, Seppo Helisalmi, Mitja I. Kurki, Juha E. Jääskeläinen, Ville Leinonen
Published 2020-09-01

cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases

by Philipp Spitzer, Hans Wolfgang Klafki, Kaj Blennow, Luc Buée, Hermann Esselmann, Sanna-Kaisa Herruka, Connie Jimenez, Peter Klivenyi, Piotr Lewczuk, Juan Manuel Maler, Katrin Markus, Helmut E. Meyer, Chris Morris, Thorsten Müller, Markus Otto, Lucilla Parnetti, Hilkka Soininen, Susanna Schraen, Charlotte Teunissen, Laszlo Vecsei, Henrik Zetterberg, Jens Wiltfang
Published 2010-01-01

Evaluating combinations of diagnostic tests to discriminate different dementia types

by Marie Bruun, Hanneke F.M. Rhodius‐Meester, Juha Koikkalainen, Marta Baroni, Le Gjerum, Afina W. Lemstra, Frederik Barkhof, Anne M. Remes, Timo Urhemaa, Antti Tolonen, Daniel Rueckert, Mark vanGils, Kristian S. Frederiksen, Gunhild Waldemar, Philip Scheltens, Patrizia Mecocci, Hilkka Soininen, Jyrki Lötjönen, Steen G. Hasselbalch, Wiesje M. van derFlier
Published 2018-01-01