Myeloid Cell Modulation by Tumor-Derived Extracellular Vesicles

by Ihor Arkhypov, Samantha Lasser, Vera Petrova, Rebekka Weber, Christopher Groth, Jochen Utikal, Peter Altevogt, Viktor Umansky
Published 2020-08-01

Myeloid-Derived Suppressor Cells Hinder the Anti-Cancer Activity of Immune Checkpoint Inhibitors

by Rebekka Weber, Rebekka Weber, Rebekka Weber, Viktor Fleming, Viktor Fleming, Viktor Fleming, Xiaoying Hu, Xiaoying Hu, Vasyl Nagibin, Vasyl Nagibin, Christopher Groth, Christopher Groth, Peter Altevogt, Peter Altevogt, Jochen Utikal, Jochen Utikal, Viktor Umansky, Viktor Umansky
Published 2018-06-01

Predicting response to pembrolizumab in metastatic melanoma by a new personalization algorithm

by Neta Tsur, Yuri Kogan, Evgenia Avizov-Khodak, Désirée Vaeth, Nils Vogler, Jochen Utikal, Michal Lotem, Zvia Agur
Published 2019-10-01

Mithramycin A and Mithralog EC-8042 Inhibit SETDB1 Expression and Its Oncogenic Activity in Malignant Melanoma

by Aniello Federico, Tamara Steinfass, Lionel Larribère, Daniel Novak, Francisco Morís, Luz-Elena Núñez, Viktor Umansky, Jochen Utikal
Published 2020-09-01

NF1-RAC1 axis regulates migration of the melanocytic lineage

by Lionel Larribère, Yohanes Cakrapradipta Wibowo, Nitin Patil, Mohammed Abba, Isabel Tundidor, Rubén Gerardo Aguiñón Olivares, Heike Allgayer, Jochen Utikal
Published 2020-12-01

Desmoglein 2 depletion leads to increased migration and upregulation of the chemoattractant secretoneurin in melanoma cells.

by Wiebke K Peitsch, Yvette Doerflinger, Reiner Fischer-Colbrie, Volker Huck, Alexander T Bauer, Jochen Utikal, Sergij Goerdt, Stefan W Schneider
Published 2014-01-01

Multiple epidermotropic melanoma metastases developing during BRAF and MEK inhibitor therapy

by Raphael Reinhard, MD, Christoffer Gebhardt, MD, Nolwenn Maurier, MD, Lionel Larribère, PhD, Azadeh Orouji, MD, Jochen Utikal, MD
Published 2018-03-01

Enhanced expression of CD39 and CD73 on T cells in the regulation of anti-tumor immune responses

by Ivan Shevchenko, Andreas Mathes, Christopher Groth, Svetlana Karakhanova, Verena Müller, Jochen Utikal, Jens Werner, Alexandr V. Bazhin, Viktor Umansky
Published 2020-01-01

An RNAi Screen Reveals an Essential Role for HIPK4 in Human Skin Epithelial Differentiation from iPSCs

by Lionel Larribère, Marta Galach, Daniel Novak, Karla Arévalo, Hans Christian Volz, Hans-Jürgen Stark, Petra Boukamp, Michael Boutros, Jochen Utikal
Published 2017-10-01

Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons

by Sandra Horschitz, Friederike Matthäus, Anja Groß, Jan Rosner, Marta Galach, Wolfgang Greffrath, Rolf-Detlef Treede, Jochen Utikal, Patrick Schloss, Andreas Meyer-Lindenberg
Published 2015-07-01

Eosinophil accumulation predicts response to melanoma treatment with immune checkpoint inhibitors

by Sonja C. S. Simon, Xiaoying Hu, Jasper Panten, Mareike Grees, Simon Renders, Daniel Thomas, Rebekka Weber, Torsten J. Schulze, Jochen Utikal, Viktor Umansky
Published 2020-01-01

391 A first-in-human study of intratumoral SAR441000, an mRNA mixture encoding IL-12sc, interferon alpha2b, GM-CSF and IL-15sushi as monotherapy and in combination with cemiplimab...

by Evelyna Derhovanessian, Nicolas Acquavella, Christophe Massard, Carmen Loquai, Jochen Utikal, Jean-Francois Baurain, Oliver Bechter, Marie-Laure Ozoux, Rahul Marpadga, Esteban-Rodrigo Imedio
Published 2020-11-01

Optimized dendritic cell vaccination induces potent CD8 T cell responses and anti-tumor effects in transgenic mouse melanoma models

by Mareike Grees, Adi Sharbi-Yunger, Christos Evangelou, Daniel Baumann, Gal Cafri, Esther Tzehoval, Stefan B. Eichmüller, Rienk Offringa, Jochen Utikal, Lea Eisenbach, Viktor Umansky
Published 2018-07-01

Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response

by Mathias Bernhardt, Daniel Novak, Yassen Assenov, Elias Orouji, Nathalie Knappe, Kasia Weina, Maike Reith, Lionel Larribere, Christoffer Gebhardt, Christoph Plass, Viktor Umansky, Jochen Utikal
Published 2017-05-01

HER3-Receptor-Mediated STAT3 Activation Plays a Central Role in Adaptive Resistance toward Vemurafenib in Melanoma

by Laura Hüser, Marianthi-Maria Kokkaleniou, Karol Granados, Jennifer Dworacek, Aniello Federico, Marlene Vierthaler, Daniel Novak, Ihor Arkhypov, Thomas Hielscher, Viktor Umansky, Peter Altevogt, Jochen Utikal
Published 2020-12-01

TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes

by Katherine Sattler, Ibrahim El-Battrawy, Lukas Cyganek, Siegfried Lang, Huan Lan, Xin Li, Zhihan Zhao, Jochen Utikal, Thomas Wieland, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin
Published 2021-07-01

Early Exanthema Upon Vemurafenib Plus Cobimetinib Is Associated With a Favorable Treatment Outcome in Metastatic Melanoma: A Retrospective Multicenter DeCOG Study

by Katharina C. Kähler, Ralf Gutzmer, Friedegrund Meier, Friedegrund Meier, Lisa Zimmer, Markus Heppt, Anja Gesierich, Kai-Martin Thoms, Jochen Utikal, Jochen Utikal, Jessica C. Hassel, Carmen Loquai, Claudia Pföhler, Lucie Heinzerling, Lucie Heinzerling, Martin Kaatz, Daniela Göppner, Annette Pflugfelder, Ann-Sophie Bohne, Imke Satzger, Lydia Reinhardt, Lydia Reinhardt, Jan-Malte Placke, Dirk Schadendorf, Selma Ugurel
Published 2021-05-01

Imidazopyridines as Potent KDM5 Demethylase Inhibitors Promoting Reprogramming Efficiency of Human iPSCs

by Yasamin Dabiri, Rodrigo A. Gama-Brambila, Katerina Taškova, Kristina Herold, Stefanie Reuter, James Adjaye, Jochen Utikal, Ralf Mrowka, Jichang Wang, Miguel A. Andrade-Navarro, Xinlai Cheng
Published 2019-02-01

Willingness to pay for a cure of low-risk melanoma patients in Germany.

by Matthias Augustin, Christine Blome, Andrea Forschner, Ralf Gutzmer, Axel Hauschild, Lucie Heinzerling, Elisabeth Livingstone, Carmen Loquai, Dirk Schadendorf, Jochen Utikal, Tobias Wagner, Sophia Wilden, Katharina C Kähler
Published 2018-01-01

Patient Preferences in Adjuvant and Palliative Treatment of Advanced Melanoma: A Discrete Choice Experiment

by Juliane Weilandt, Katharina Diehl, Marthe Lisa Schaarschmidt, Felix Kieker, Bianca Sasama, Melanie Pronk, Jan Ohletz, Andreas Könnecke, Verena Müller, Jochen Utikal, Uwe Hillen, Wolfgang Harth, Wiebke K. Peitsch
Published 2020-03-01