GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field

by Musante, CJ, Abernethy, DR, Allerheiligen, SR, Zager, MG, Lauffenburger, Douglas A
Published 2017

Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions

by Naegle, Kristen Marie, White, Forest M., Lauffenburger, Douglas A., Yaffe, Michael B.
Published 2014

A mammalian functional-genetic approach to characterizing cancer therapeutics

by Williams, Richard T., Jiang, Hai, Hemann, Michael, Pritchard, Justin R., Lauffenburger, Douglas A
Published 2011

Qualitatively Different T Cell Phenotypic Responses to IL-2 versus IL-15 Are Unified by Identical Dependences on Receptor Signal Strength and Duration

by Arneja, Abhinav, Johnson, Hannah, Gabrovsek, Laura, White, Forest M., Lauffenburger, Douglas A
Published 2015

High-throughput protease activity cytometry reveals dose-dependent heterogeneity in PMA-mediated ADAM17 activation

by Wu, Lidan, Claas, Allison Mary, Sarkar, Aniruddh, Lauffenburger, Douglas A, Han, Jongyoon
Published 2017

Logic-Based Models for the Analysis of Cell Signaling Networks

by Morris, Melody Kay, Saez-Rodriguez, Julio, Sorger, Peter K., Lauffenburger, Douglas A.
Published 2012

Detecting Kinase Activities from Single Cell Lysate Using Concentration-Enhanced Mobility Shift Assay

by Cheow, Lih Feng, Sarkar, Aniruddh, Kolitz, Sarah, Han, Jongyoon, Lauffenburger, Douglas A.
Published 2015

Systematic Analysis of Quantitative Logic Model Ensembles Predicts Drug Combination Effects on Cell Signaling Networks

by Morris, Melody Kay, Clarke, David C., Osimiri, Lindsey C., Lauffenburger, Douglas A
Published 2017

Lipids promote survival, proliferation, and maintenance of differentiation of rat liver sinusoidal endothelial cells in vitro

by Hang, Ta-Chun, Lauffenburger, Douglas A., Griffith, Linda G., Stolz, Donna B.
Published 2014

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8⁺ T cells

by Palmer, Megan Joan, Mahajan, Vinay S., Chen, Jianzhu, Irvine, Darrell J, Lauffenburger, Douglas A
Published 2012

CD4+ T cell-dependent and CD4+ T cell-independent cytokine-chemokine network changes in the immune responses of HIV-infected individuals

by Lauffenburger, Douglas A, Szeto, Gregory, Alter, Galit, Irvine, Darrell J, Arnold, Kelly B.
Published 2017

Decision tree modeling predicts effects of inhibiting contractility signaling on cell motility

by Kharait, Sourabh, Hautaniemi, Sampsa, Wu, Shan, Iwabu, Akihiro, Lauffenburger, Douglas A., Wells, Alan
Published 2010

Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

by Kleiman, Laura B, Maiwald, Thomas, Conzelmann, Holger, Lauffenburger, Douglas A, Sorger, Peter K
Published 2015

Approaches to in vitro tissue regeneration with application for human disease modeling and drug development

by Young, Carissa L., Lauffenburger, Douglas A., Griffith, Linda G., Borenstein, Jeffrey T., Ebrahimkhani, Mohammad Reza
Published 2015

Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition

by Claas, Allison Mary, Atta, Lyla H., Gordonov, Simon, Meyer, Aaron Samuel, Lauffenburger, Douglas A
Published 2018

O[superscript 6]-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation

by Noonan, Ericka M., Shah, Dharini, Yaffe, Michael B, Lauffenburger, Douglas A, Samson, Leona D
Published 2014

Low-volume multiplexed proteolytic activity assay and inhibitor analysis through a pico-injector array

by Ng, Ee Xien, Jing, Tengyang, Chen, Chia-Hung, Miller, Miles Aaron, Lauffenburger, Douglas A
Published 2018

Time series modeling of live-cell shape dynamics for image-based phenotypic profiling

by Wells, Alan, Gordonov, Simon, Hwang, Mun Kyung, Gertler, Frank, Lauffenburger, Douglas A, Bathe, Mark
Published 2017

RAS Mutations Impact TNF-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits along with non-ERK Pathway Effects

by Kreeger, Pamela K., Alford, Shannon K., Mandhana, Roli, Haigis, Kevin M., Lauffenburger, Douglas A
Published 2010

Sustained epidermal growth factor receptor levels and activation by tethered ligand binding enhances osteogenic differentiation of multi-potent marrow stromal cells

by Platt, Manu O., Roman, Arian J., Wells, Alan, Lauffenburger, Douglas A., Griffith, Linda G.
Published 2012