Dual Molecular Signals Mediate the Bacterial Response to Outer-Membrane Stress

by Lima, Santiago, Guo, Monica S., Chaba, Rachna, Gross, Carol A., Sauer, Robert T
Published 2015

Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

by Schmitz, Karl R., Carney, Daniel W., Sello, Jason K., Sauer, Robert T
Published 2015

Roles of the ClpX IGF loops in ClpP association, dissociation, and protein degradation

by Amor, Alvaro J., Schmitz, Karl R., Baker, Tania A., Sauer, Robert T.
Published 2022

Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX

by Stinson, Benjamin Michael, Baytshtok, Vladimir, Schmitz, Karl Robert, Baker, Tania, Sauer, Robert T.
Published 2017

Crystal structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine

by Glynn, Steven E., Martin, Andreas, Nager, Andrew Ross, Baker, Tania, Sauer, Robert T
Published 2012

Substrate-guided optimization of the syringolins yields potent proteasome inhibitors with activity against leukemia cell lines

by Totaro, Kyle A., Barthelme, Dominik, Simpson, Peter T., Sello, Jason K., Sauer, Robert T.
Published 2017

Architecture and assembly of the archaeal Cdc48*20S proteasome

by Barthelme, Dominik, Chen, James Z., Grabenstatter, Jonathan Dean, Baker, Tania, Sauer, Robert T
Published 2014

Mechanochemical basis of protein degradation by a double-ring AAA+ machine

by Iosefson, Ohad, Olivares, Adrian O., Baker, Tania, Nager, Andrew Ross, Sauer, Robert T
Published 2015

Distinct quaternary structures of the AAA+ Lon protease control substrate degradation

by Vieux (Kloss), Wohlever, Matthew Lee, Chen, James Z., Baker, Tania, Sauer, Robert T
Published 2013

Effect of directional pulling on mechanical protein degradation by ATP-dependent proteolytic machines

by Olivares, Adrian O., Kotamarthi, Hema Chandra, Stein, Benjamin Joseph, Sauer, Robert T., Baker, Tania
Published 2018

Highly Dynamic Interactions Maintain Kinetic Stability of the ClpXP Protease During the ATP-Fueled Mechanical Cycle

by Sello, Jason K., Sauer, Robert T., Amor, Alvaro Jorge, Baker, Tania, Schmitz, Karl R.
Published 2017

Examination of a Structural Model of Peptidomimicry by Cyclic Acyldepsipeptide Antibiotics in Their Interaction with the ClpP Peptidase

by Carney, Daniel W., Scruse, Anthony C., Sello, Jason K., Schmitz, Karl Robert, Sauer, Robert T.
Published 2017

Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity

by Carney, Daniel W., Schmitz, Karl R., Truong, Jonathan V., Sello, Jason K., Sauer, Robert T
Published 2015

Signal integration by DegS and RseB governs the  E-mediated envelope stress response in Escherichia coli

by Chaba, Rachna, Alba, Benjamin M., Guo, Monica S., Sohn, Jungsan, Ahuja, Nidhi, Gross, Carol A., Sauer, Robert T
Published 2014

Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine

by Stinson, Benjamin Michael, Nager, Andrew Ross, Glynn, Steven E., Schmitz, Karl R., Baker, Tania, Sauer, Robert T
Published 2013

Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism

by Yin, Yeshi, Withers, T. Ryan, Wang, Xin, Yu, Hongwei D., de Regt, Anna Katherine, Baker, Tania, Sauer, Robert T.
Published 2017

A Simple Fragment of Cyclic Acyldepsipeptides Is Necessary and Sufficient for ClpP Activation and Antibacterial Activity

by Carney, Daniel W., Compton, Corey L., Stevens, Julia P., Sello, Jason K., Schmitz, Karl Robert, Sauer, Robert T.
Published 2017

Deciphering the Roles of Multicomponent Recognition Signals by the AAA+ Unfoldase ClpX

by Montaño, Sherwin P., Rice, Phoebe A., Sauer, Robert T., Baker, Tania, Ling, Lorraine, Ph. D. Massachusetts Institute of Technology
Published 2017

Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens

by Amberg-Johnson, Katherine, Ganesan, Suresh M., Lorenzi, Hernan A., Niles, Jacquin C., Yeh, Ellen, Hari, Sanjay B., Sauer, Robert T.
Published 2018

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium Tuberculosis Proteasome

by Totaro, Kyle A., Barthelme, Dominik, Simpson, Peter T., Jiang, Xiuju, Lin, Gang, Nathan, Carl F., Sauer, Robert T., Sello, Jason K.
Published 2018