Epigenetic mechanisms in pulmonary arterial hypertension: the need for global perspectives

by Prakash Chelladurai, Werner Seeger, Soni Savai Pullamsetti
Published 2016-06-01

Exposomes to Exosomes: Exosomes as Tools to Study Epigenetic Adaptive Mechanisms in High-Altitude Humans

by Manju Padmasekar, Rajkumar Savai, Werner Seeger, Soni Savai Pullamsetti
Published 2021-08-01

Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer

by Steffen Kiehl, Tobias Zimmermann, Rajkumar Savai, Soni S. Pullamsetti, Werner Seeger, Marek Bartkuhn, Reinhard H. Dammann
Published 2017-06-01

Hidden Treasures: Macrophage Long Non-Coding RNAs in Lung Cancer Progression

by Annika Karger, Rajender Nandigama, Albrecht Stenzinger, Friedrich Grimminger, Soni Savai Pullamsetti, Werner Seeger, Rajkumar Savai
Published 2021-08-01

Metabolism in tumour-associated macrophages: a quid pro quo with the tumour microenvironment

by Xiang Zheng, Siavash Mansouri, Annika Krager, Friedrich Grimminger, Werner Seeger, Soni S. Pullamsetti, Craig E. Wheelock, Rajkumar Savai
Published 2020-10-01

Depletion of Numb and Numblike in Murine Lung Epithelial Cells Ameliorates Bleomycin-Induced Lung Fibrosis by Inhibiting the β-Catenin Signaling Pathway

by Alessandro Ianni, Michael Hofmann, Poonam Kumari, Shahriar Tarighi, Hamza M Al-Tamari, André Görgens, Bernd Giebel, Hendrik Nolte, Marcus Krüger, Isabelle Salwig, Isabelle Salwig, Soni Savai Pullamsetti, Soni Savai Pullamsetti, Andreas Günther, Andreas Günther, André Schneider, Thomas Braun, Thomas Braun
Published 2021-05-01

Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling.

by Xia Tian, Christina Vroom, Hossein Ardeschir Ghofrani, Norbert Weissmann, Ewa Bieniek, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly, Soni Savai Pullamsetti
Published 2011-04-01

Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.

by Piotr Sklepkiewicz, Ralph Theo Schermuly, Xia Tian, Hossein Ardeschir Ghofrani, Norbert Weissmann, Daniel Sedding, Tarek Kashour, Werner Seeger, Friedrich Grimminger, Soni Savai Pullamsetti
Published 2011-04-01

Hot topics in the mechanisms of pulmonary arterial hypertension disease: cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure

by Edda Spiekerkoetter, Elena A. Goncharova, Christophe Guignabert, Kurt Stenmark, Grazyna Kwapiszewska, Marlene Rabinovitch, Norbert Voelkel, Harm J. Bogaard, Brian Graham, Soni S. Pullamsetti, Wolfgang M. Kuebler
Published 2019-11-01

Evaluation of Angiogenesis Using Micro-Computed Tomography in a Xenograft Mouse Model of Lung Cancer

by Rajkumar Savai, Alexander Claus Langheinrich, Ralph Theo Schermuly, Soni Savai Pullamsetti, Rio Dumitrascu, Horst Traupe, Wigbert Stephan Rau, Werner Seeger, Friedrich Grimminger, Gamal Andre Banat
Published 2009-01-01

Epigenetic Inactivation of the Tumor Suppressor <i>IRX1</i> Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis

by Miriam M. Küster, Marc A. Schneider, Antje M. Richter, Sarah Richtmann, Hauke Winter, Mark Kriegsmann, Soni S. Pullamsetti, Thorsten Stiewe, Rajkumar Savai, Thomas Muley, Reinhard H. Dammann
Published 2020-11-01

Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma.

by G-Andre Banat, Aleksandra Tretyn, Soni Savai Pullamsetti, Jochen Wilhelm, Andreas Weigert, Catherine Olesch, Katharina Ebel, Thorsten Stiewe, Friedrich Grimminger, Werner Seeger, Ludger Fink, Rajkumar Savai
Published 2015-01-01

FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis

by Hamza M Al‐Tamari, Swati Dabral, Anja Schmall, Pouya Sarvari, Clemens Ruppert, Jihye Paik, Ronald A DePinho, Friedrich Grimminger, Oliver Eickelberg, Andreas Guenther, Werner Seeger, Rajkumar Savai, Soni S Pullamsetti
Published 2018-02-01

Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican

by David Brunn, Kati Turkowski, Stefan Günther, Andreas Weigert, Thomas Muley, Mark Kriegsmann, Hauke Winter, Reinhard H. Dammann, Georgios T. Stathopoulos, Michael Thomas, Andreas Guenther, Friedrich Grimminger, Soni S. Pullamsetti, Werner Seeger, Rajkumar Savai
Published 2021-01-01

A RASSF1A-HIF1α loop drives Warburg effect in cancer and pulmonary hypertension

by Swati Dabral, Christian Muecke, Chanil Valasarajan, Mario Schmoranzer, Astrid Wietelmann, Gregg L. Semenza, Michael Meister, Thomas Muley, Tamina Seeger-Nukpezah, Christos Samakovlis, Norbert Weissmann, Friedrich Grimminger, Werner Seeger, Rajkumar Savai, Soni S. Pullamsetti
Published 2019-05-01

Fibroblast Growth Factor—14 Acts as Tumor Suppressor in Lung Adenocarcinomas

by Kati Turkowski, Frederik Herzberg, Stefan Günther, David Brunn, Andreas Weigert, Michael Meister, Thomas Muley, Mark Kriegsmann, Marc A. Schneider, Hauke Winter, Michael Thomas, Friedrich Grimminger, Werner Seeger, Soni Savai Pullamsetti, Rajkumar Savai
Published 2020-07-01

5-HT2B Receptor Antagonists Inhibit Fibrosis and Protect from RV Heart Failure

by Wiebke Janssen, Yves Schymura, Tatyana Novoyatleva, Baktybek Kojonazarov, Mario Boehm, Astrid Wietelmann, Himal Luitel, Kirsten Murmann, Damian Richard Krompiec, Aleksandra Tretyn, Soni Savai Pullamsetti, Norbert Weissmann, Werner Seeger, Hossein Ardeschir Ghofrani, Ralph Theo Schermuly
Published 2015-01-01

Effects of macitentan and tadalafil monotherapy or their combination on the right ventricle and plasma metabolites in pulmonary hypertensive rats

by Argen Mamazhakypov, Astrid Weiß, Sven Zukunft, Akylbek Sydykov, Baktybek Kojonazarov, Jochen Wilhelm, Christina Vroom, Aleksandar Petrovic, Djuro Kosanovic, Norbert Weissmann, Werner Seeger, Ingrid Fleming, Marc Iglarz, Friedrich Grimminger, Hossein A. Ghofrani, Soni S. Pullamsetti, Ralph T. Schermuly
Published 2020-11-01

Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes

by Caroline Bouchard, Peeyush Sahu, Marion Meixner, René Reiner Nötzold, Marco B. Rust, Elisabeth Kremmer, Regina Feederle, Gene Hart-Smith, Florian Finkernagel, Marek Bartkuhn, Soni Savai Pullamsetti, Andrea Nist, Thorsten Stiewe, Sjaak Philipsen, Uta-Maria Bauer
Published 2018-09-01

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

by Astrid Weiss, Moritz Christian Neubauer, Dinesh Yerabolu, Baktybek Kojonazarov, Beate Christiane Schlueter, Lavinia Neubert, Danny Jonigk, Nelli Baal, Clemens Ruppert, Peter Dorfmuller, Soni Savai Pullamsetti, Norbert Weissmann, Hossein-Ardeschir Ghofrani, Friedrich Grimminger, Werner Seeger, Ralph Theo Schermuly
Published 2019-05-01