Selection of a Single Domain Antibody, Specific for an HLA-Bound Epitope of the Mycobacterial Ag85B Antigen

by Paola A. Ortega, Mayra Silva-Miranda, Mayra Silva-Miranda, Alfredo Torres-Larios, Eduardo Campos-Chávez, Kees C. L. C. M. Franken, Tom H. M. Ottenhoff, Juraj Ivanyi, Clara Espitia, Clara Espitia
Published 2020-10-01

Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children

by John Espen Gjøen, Synne Jenum, Dhanasekaran Sivakumaran, Aparna Mukherjee, Ragini Macaden, Sushil K. Kabra, Rakesh Lodha, Tom H. M. Ottenhoff, Marielle C. Haks, Timothy Mark Doherty, Christian Ritz, Harleen M. S. Grewal
Published 2017-07-01

Antibody Subclass and Glycosylation Shift Following Effective TB Treatment

by Patricia S. Grace, Patricia S. Grace, Sepideh Dolatshahi, Lenette L. Lu, Adam Cain, Fabrizio Palmieri, Linda Petrone, Sarah M. Fortune, Tom H. M. Ottenhoff, Douglas A. Lauffenburger, Delia Goletti, Simone A. Joosten, Galit Alter
Published 2021-07-01

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

by Cornelis J. Korbee, Matthias T. Heemskerk, Dragi Kocev, Elisabeth van Strijen, Omid Rabiee, Kees L. M. C. Franken, Louis Wilson, Nigel D. L. Savage, Sašo Džeroski, Mariëlle C. Haks, Tom H. M. Ottenhoff
Published 2018-01-01

Polymorphisms in autophagy genes and susceptibility to tuberculosis.

by Mario Songane, Johanneke Kleinnijenhuis, Bachti Alisjahbana, Edhyana Sahiratmadja, Ida Parwati, Marije Oosting, Theo S Plantinga, Leo A B Joosten, Mihai G Netea, Tom H M Ottenhoff, Esther van de Vosse, Reinout van Crevel
Published 2012-01-01

Identification of probable early-onset biomarkers for tuberculosis disease progression.

by Jayne S Sutherland, Philip C Hill, Ifedayo M Adetifa, Bouke C de Jong, Simon Donkor, Simone A Joosten, Lizet Opmeer, Marielle C Haks, Tom H M Ottenhoff, Richard A Adegbola, Martin O C Ota
Published 2011-01-01

Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana

by Ernest Adankwah, Christian Lundtoft, Alptekin Güler, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Ertan Mayatepek, Ellis Owusu-Dabo, Ellis Owusu-Dabo, Richard Odame Phillips, Richard Odame Phillips, Norman Nausch, Marc Jacobsen
Published 2019-07-01

Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment.

by Leopold D Tientcheu, Mariëlle C Haks, Schadrac C Agbla, Jayne S Sutherland, Ifedayo M Adetifa, Simon Donkor, Edwin Quinten, Mohammed Daramy, Martin Antonio, Beate Kampmann, Tom H M Ottenhoff, Hazel M Dockrell, Martin O Ota
Published 2016-05-01

Analysis of Mycobacterium tuberculosis-specific CD8 T-cells in patients with active tuberculosis and in individuals with latent infection.

by Nadia Caccamo, Giuliana Guggino, Serena Meraviglia, Giuseppe Gelsomino, Paola Di Carlo, Lucina Titone, Marialuisa Bocchino, Domenico Galati, Alessandro Matarese, Jan Nouta, Michel R Klein, Alfredo Salerno, Alessandro Sanduzzi, Francesco Dieli, Tom H M Ottenhoff
Published 2009-01-01

A novel view on the pathogenesis of complications after intravesical BCG for bladder cancer

by Manu P. Bilsen, Krista E. van Meijgaarden, Hanna K. de Jong, Simone A. Joosten, Corine Prins, Lucia J.M. Kroft, Jacqueline T. Jonker, Stijn Crobach, Rob C. Pelger, Tom H.M. Ottenhoff, Sandra M. Arend
Published 2018-07-01

Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

by Simone A Joosten, Krista E van Meijgaarden, Pascale C van Weeren, Fatima Kazi, Annemieke Geluk, Nigel D L Savage, Jan W Drijfhout, Darren R Flower, Willem A Hanekom, Michèl R Klein, Tom H M Ottenhoff
Published 2010-02-01

Disparate Tuberculosis Disease Development in Macaque Species Is Associated With Innate Immunity

by Karin Dijkman, Richard A. W. Vervenne, Claudia C. Sombroek, Charelle Boot, Sam O. Hofman, Krista E. van Meijgaarden, Tom H. M. Ottenhoff, Clemens H. M. Kocken, Krista G. Haanstra, Michel P. M. Vierboom, Frank A. W. Verreck
Published 2019-11-01

Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies...

by Krista E van Meijgaarden, Bhagwati Khatri, Steven G Smith, Anne M F H Drittij, Roelof A de Paus, Jelle J Goeman, Mei M Ho, Hazel M Dockrell, Helen McShane, Simone A Joosten, Tom H M Ottenhoff
Published 2018-01-01

NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis.

by Gerben Ferwerda, Stephen E Girardin, Bart-Jan Kullberg, Lionel Le Bourhis, Dirk J de Jong, Dennis M L Langenberg, Reinout van Crevel, Gosse J Adema, Tom H M Ottenhoff, Jos W M Van der Meer, Mihai G Netea
Published 2005-11-01

Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine

by Francesco Santoro, Alessia Donato, Simone Lucchesi, Sara Sorgi, Alice Gerlini, Marielle C. Haks, Tom H. M. Ottenhoff, Patricia Gonzalez-Dias, VSV-EBOVAC Consortium, VSV-EBOPLUS Consortium, Helder I. Nakaya, Angela Huttner, Claire-Anne Siegrist, Donata Medaglini, Gianni Pozzi
Published 2021-01-01

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines.

by Steven G Smith, Kaatje Smits, Simone A Joosten, Krista E van Meijgaarden, Iman Satti, Helen A Fletcher, Nadia Caccamo, Francesco Dieli, Francoise Mascart, Helen McShane, Hazel M Dockrell, Tom H M Ottenhoff, TBVI TB Biomarker Working Group
Published 2015-01-01

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish

by Jôsimar D. Moreira, Jôsimar D. Moreira, Bjørn E. V. Koch, Suzanne van Veen, Kimberley V. Walburg, Frank Vrieling, Tânia Mara Pinto Dabés Guimarães, Annemarie H. Meijer, Herman P. Spaink, Tom H. M. Ottenhoff, Mariëlle C. Haks, Matthias T. Heemskerk
Published 2020-02-01

Genetic association and expression studies indicate a role of toll-like receptor 8 in pulmonary tuberculosis.

by Sonia Davila, Martin L Hibberd, Ranjeeta Hari Dass, Hazel E E Wong, Edhyana Sahiratmadja, Carine Bonnard, Bachti Alisjahbana, Jeffrey S Szeszko, Yanina Balabanova, Francis Drobniewski, Reinout van Crevel, Esther van de Vosse, Sergey Nejentsev, Tom H M Ottenhoff, Mark Seielstad
Published 2008-10-01

Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method.

by Susanna Commandeur, Mariateresa Coppola, Karin Dijkman, Annemieke H Friggen, Krista E van Meijgaarden, Susan J F van den Eeden, Louis Wilson, Jolien J van der Ploeg-van Schip, Kees L M C Franken, Annemieke Geluk, Tom H M Ottenhoff
Published 2014-01-01

T-cell regulation in lepromatous leprosy.

by Kidist Bobosha, Louis Wilson, Krista E van Meijgaarden, Yonas Bekele, Martha Zewdie, Jolien J van der Ploeg-van Schip, Markos Abebe, Jemal Hussein, Saraswoti Khadge, Kapil D Neupane, Deanna A Hagge, Ekaterina S Jordanova, Abraham Aseffa, Tom H M Ottenhoff, Annemieke Geluk
Published 2014-04-01