A model for how signal duration can determine distinct outcomes of gene transcription programs.

by Kevin D Fowler, Vijay K Kuchroo, Arup K Chakraborty
Published 2012-01-01

Combinatorial prediction of marker panels from single‐cell transcriptomic data

by Conor Delaney, Alexandra Schnell, Louis V Cammarata, Aaron Yao‐Smith, Aviv Regev, Vijay K Kuchroo, Meromit Singer
Published 2019-10-01

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

by Gerd Meyer zu Horste, Chuan Wu, Chao Wang, Le Cong, Mathias Pawlak, Youjin Lee, Wassim Elyaman, Sheng Xiao, Aviv Regev, Vijay K. Kuchroo
Published 2016-07-01

TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection.

by Pushpa Jayaraman, Miye K Jacques, Chen Zhu, Katherine M Steblenko, Britni L Stowell, Asaf Madi, Ana C Anderson, Vijay K Kuchroo, Samuel M Behar
Published 2016-03-01

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

by Amit K. Gandhi, Zhen-Yu J. Sun, Walter M. Kim, Yu-Hwa Huang, Yasuyuki Kondo, Daniel A. Bonsor, Eric J. Sundberg, Gerhard Wagner, Vijay K. Kuchroo, Gregory A. Petsko, Richard S. Blumberg
Published 2021-03-01

Chronic stress physically spares but functionally impairs innate-like invariant T cells

by Patrick T. Rudak, Joshua Choi, Katie M. Parkins, Kelly L. Summers, Dwayne N. Jackson, Paula J. Foster, Anton I. Skaro, Ken Leslie, Vivian C. McAlister, Vijay K. Kuchroo, Wataru Inoue, Olivier Lantz, S.M. Mansour Haeryfar
Published 2021-04-01

Checkpoint Receptor TIGIT Expressed on Tim-1+ B Cells Regulates Tissue Inflammation

by Sheng Xiao, Lloyd Bod, Nathalie Pochet, Savithri Balasubramanian Kota, Dan Hu, Asaf Madi, Jessica Kilpatrick, Jingwen Shi, Allen Ho, Huiyuan Zhang, Raymond Sobel, Howard L. Weiner, Terry B. Strom, Francisco J. Quintana, Nicole Joller, Vijay K. Kuchroo
Published 2020-07-01

WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis

by Amlan Biswas, Dror S. Shouval, Alexandra Griffith, Jeremy A. Goettel, Michael Field, Yu Hui Kang, Liza Konnikova, Erin Janssen, Naresh Singh Redhu, Adrian J. Thrasher, Talal Chatila, Vijay K. Kuchroo, Raif S Geha, Luigi D. Notarangelo, Sung-Yun Pai, Bruce H. Horwitz, Scott B. Snapper
Published 2018-05-01

Blockade of Tim-3 binding to phosphatidylserine and CEACAM1 is a shared feature of anti-Tim-3 antibodies that have functional efficacy

by Catherine A. Sabatos-Peyton, James Nevin, Ansgar Brock, John D. Venable, Dewar J. Tan, Nasim Kassam, Fangmin Xu, John Taraszka, Luke Wesemann, Thomas Pertel, Nandini Acharya, Max Klapholz, Yassaman Etminan, Xiaomo Jiang, Yu-Hwa Huang, Richard S. Blumberg, Vijay K. Kuchroo, Ana C. Anderson
Published 2018-02-01

Transcriptional signature of human pro-inflammatory TH17 cells identifies reduced IL10 gene expression in multiple sclerosis

by Dan Hu, Samuele Notarbartolo, Tom Croonenborghs, Bonny Patel, Ron Cialic, Tun-Hsiang Yang, Dominik Aschenbrenner, Karin M. Andersson, Marco Gattorno, Minh Pham, Pia Kivisakk, Isabelle V. Pierre, Youjin Lee, Karun Kiani, Maria Bokarewa, Emily Tjon, Nathalie Pochet, Federica Sallusto, Vijay K. Kuchroo, Howard L. Weiner
Published 2017-11-01