Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

by Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y, Abraham, Brian J, Lee, Tong Ihn, Bradner, James E, Weintraub, Abraham Selby, Young, Richard A.
Published 2017

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

by Schuijers, Jurian, Day, Daniel Sindt, Hnisz, Denes, Lee, Tong Ihn, Manteiga, John Colonnese, Weintraub, Abraham Selby, Zamudio Montes de Oca, Alicia, Young, Richard A.
Published 2018

Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

by Dowen, Jill M, Fan, Zi Peng, Hnisz, Denes, Ren, Gang, Abraham, Brian J, Weintraub, Abraham S, Schuijers, Jurian, Lee, Tong Ihn, Zhao, Keji, Zhang, Lyndon Nuoxi, Young, Richard A.
Published 2016

3D Chromosome Regulatory Landscape of Human Pluripotent Cells

by Ji, Xiong, Powell, Benjamin E, Shachar, Sigal, Hnisz, Denes, Pegoraro, Gianluca, Lee, Tong Ihn, Misteli, Tom, Dadon, Daniel Benjamin, Fan, Zi Peng, Borges-Rivera, Diego Ramon, Weintraub, Abraham Selby, Jaenisch, Rudolf, Young, Richard A.
Published 2017

PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes

by Weintraub, Abraham S., Buenrostro, Jason D., Cheng, Christine S., Regev, Aviv, Young, Richard A., Soto Feliciano, Yadira M., Bartlebaugh, Jordan M. E., Sanchez-Rivera, Francisco Javier, Bhutkar, Arjun, Jacks, Tyler E., Hemann, Michael, Liu, Yunpeng,S.M.Massachusetts Institute of Technology
Published 2018

Small genomic insertions form enhancers that misregulate oncogenes

by Hnisz, Denes, Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Weintraub, Abraham Selby, Kwiatkowski, Nick, Li, Charles Han, Lee, Tong Ihn, Young, Richard A.
Published 2017

Activation of proto-oncogenes by disruption of chromosome neighborhoods

by Hnisz, D., Day, D. S., Valton, A.-L, Bak, R. O., Goldmann, J., Lajoie, B. R., Sigova, A. A., Lee, T. I., Porteus, M. H., Dekker, J., Weintraub, Abraham Selby, Li, Charles Han, Reddy, Jessica, Borges-Rivera, Diego Ramon, Jaenisch, Rudolf, Fan, Zi Peng, Young, Richard A.
Published 2017

YY1 Is a Structural Regulator of Enhancer-Promoter Loops

by Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Bradner, James E., Gray, Nathanael S., Weintraub, Abraham Selby, Li, Charles Han, Zamudio Montes de Oca, Alicia, Jaenisch, Rudolf, Young, Richard A.
Published 2018

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

by Clark, Victoria E, Harmancı, Akdes Serin, Bai, Hanwen, Youngblood, Mark W, Lee, Tong Ihn, Baranoski, Jacob F, Ercan-Sencicek, A Gulhan, Abraham, Brian J, Weintraub, Abraham S, Hnisz, Denes, Simon, Matthias, Krischek, Boris, Erson-Omay, E Zeynep, Henegariu, Octavian, Carrión-Grant, Geneive, Mishra-Gorur, Ketu, Durán, Daniel, Goldmann, Johanna E, Schramm, Johannes, Goldbrunner, Roland, Piepmeier, Joseph M, Vortmeyer, Alexander O, Günel, Jennifer Moliterno, Bilgüvar, Kaya, Yasuno, Katsuhito, Günel, Murat, Young, Richard A.
Published 2017

STAG2 loss reshapes oncogenic enhancer-promoter looping in Ewing sarcoma

by Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham Selby, Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly
Published 2021