New Insights into Genome Structure: Genes of a Feather Stick Together

by Hnisz, Denes, Young, Richard A.
Published 2018

Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control

by Hnisz, Denes, Day, Daniel S., Young, Richard A.
Published 2018

Transcriptional Addiction in Cancer

by Bradner, James E., Hnisz, Denes, Young, Richard A.
Published 2018

Regulation and Dysregulation of Chromosome Structure in Cancer

by Hnisz, Denes, Schuijers, Jurian, Li, Charles Han, Young, Richard A.
Published 2018

A Phase Separation Model for Transcriptional Control

by Hnisz, Denes, Young, Richard A., Chakraborty, Arup K., Sharp, Phillip A., Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology
Published 2018

Convergence of Developmental and Oncogenic Signaling Pathways at Transcriptional Super-Enhancers

by Hnisz, Denes, Schuijers, Jurian, Lin, Charles Y, Abraham, Brian J, Lee, Tong Ihn, Bradner, James E, Weintraub, Abraham Selby, Young, Richard A.
Published 2017

Super-Enhancers in the Control of Cell Identity and Disease

by Hnisz, Denes, Abraham, Brian Joseph, Lee, Tong Ihn, Lau, Ashley, Saint-Andre, Violaine, Sigova, Alla A., Hoke, Heather Ashley, Young, Richard A.
Published 2016

Transcriptional Dysregulation of MYC Reveals Common Enhancer-Docking Mechanism

by Schuijers, Jurian, Day, Daniel Sindt, Hnisz, Denes, Lee, Tong Ihn, Manteiga, John Colonnese, Weintraub, Abraham Selby, Zamudio Montes de Oca, Alicia, Young, Richard A.
Published 2018

Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

by Dowen, Jill M, Fan, Zi Peng, Hnisz, Denes, Ren, Gang, Abraham, Brian J, Weintraub, Abraham S, Schuijers, Jurian, Lee, Tong Ihn, Zhao, Keji, Zhang, Lyndon Nuoxi, Young, Richard A.
Published 2016

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

by Whyte, Warren A, Orlando, David A, Hnisz, Denes, Abraham, Brian J, Lin, Charles Y, Kagey, Michael H, Rahl, Peter B, Lee, Tong Ihn, Young, Richard A, Young, Richard A.
Published 2016

Rescue of Fragile X Syndrome Neurons by DNA Methylation Editing of the FMR1 Gene

by Liu, X. Shawn, Wu, Hao, Krzisch, Marine, Wu, Xuebing, Graef, John, Muffat, Julien, Hnisz, Denes, Li, Charles Han, Yuan, Bingbing, Xu, Chuanyun, Li, Yun, Vershkov, Dan, Cacace, Angela, Young, Richard A., Jaenisch, Rudolf
Published 2020

3D Chromosome Regulatory Landscape of Human Pluripotent Cells

by Ji, Xiong, Powell, Benjamin E, Shachar, Sigal, Hnisz, Denes, Pegoraro, Gianluca, Lee, Tong Ihn, Misteli, Tom, Dadon, Daniel Benjamin, Fan, Zi Peng, Borges-Rivera, Diego Ramon, Weintraub, Abraham Selby, Jaenisch, Rudolf, Young, Richard A.
Published 2017

Small genomic insertions form enhancers that misregulate oncogenes

by Hnisz, Denes, Li, Zhaodong, Weichert-Leahey, Nina, Rahman, Sunniyat, Liu, Yu, Etchin, Julia, Li, Benshang, Shen, Shuhong, Zhang, Jinghui, Look, A. Thomas, Mansour, Marc R., Abraham, Brian Joseph, Weintraub, Abraham Selby, Kwiatkowski, Nick, Li, Charles Han, Lee, Tong Ihn, Young, Richard A.
Published 2017

YY1 Is a Structural Regulator of Enhancer-Promoter Loops

by Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Bradner, James E., Gray, Nathanael S., Weintraub, Abraham Selby, Li, Charles Han, Zamudio Montes de Oca, Alicia, Jaenisch, Rudolf, Young, Richard A.
Published 2018

Coactivator condensation at super-enhancers links phase separation and gene control

by Sabari, Benjamin R., Dall'Agnese, Alessandra, Boija, Ann, Klein, Isaac A., Abraham, Brian J., Hannett, Nancy M., Guo, Yang E., Day, Daniel S., Schuijers, Jurian, Hnisz, Denes, Lee, Tong Ihn, Coffey, Eliot Leo, Shrinivas, Krishna, Zamudio Montes de Oca, Alicia, Manteiga, John Colonnese, Li, Charles Han, Vasile, Eliza, Cisse, Ibrahim I, Chakraborty, Arup K, Sharp, Phillip A., Young, Richard A.
Published 2019

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

by Clark, Victoria E, Harmancı, Akdes Serin, Bai, Hanwen, Youngblood, Mark W, Lee, Tong Ihn, Baranoski, Jacob F, Ercan-Sencicek, A Gulhan, Abraham, Brian J, Weintraub, Abraham S, Hnisz, Denes, Simon, Matthias, Krischek, Boris, Erson-Omay, E Zeynep, Henegariu, Octavian, Carrión-Grant, Geneive, Mishra-Gorur, Ketu, Durán, Daniel, Goldmann, Johanna E, Schramm, Johannes, Goldbrunner, Roland, Piepmeier, Joseph M, Vortmeyer, Alexander O, Günel, Jennifer Moliterno, Bilgüvar, Kaya, Yasuno, Katsuhito, Günel, Murat, Young, Richard A.
Published 2017

STAG2 loss reshapes oncogenic enhancer-promoter looping in Ewing sarcoma

by Adane, Biniam, Alexe, Gabriela, Seong, Bo Kyung A., Lu, Diana, Hwang, Elizabeth E., Hnisz, Denes, Lareau, Caleb A., Ross, Linda, Lin, Shan, Dela Cruz, Filemon S., Richardson, Melissa, Weintraub, Abraham Selby, Wang, Sarah, Iniguez, Amanda Balboni, Dharia, Neekesh V., Conway, Amy Saur, Robichaud, Amanda L., Tanenbaum, Benjamin, Krill-Burger, John M., Vazquez, Francisca, Schenone, Monica, Berman, Jason N., Kung, Andrew L., Carr, Steven A., Aryee, Martin J., Young, Richard A., Crompton, Brian D., Stegmaier, Kimberly
Published 2021