Mitochondrial ATP-Dependent Proteases—Biological Function and Potential Anti-Cancer Targets

by Yue Feng, Kazem Nouri, Aaron D. Schimmer
Published 2021-04-01

Cyclic AMP‐hydrolyzing phosphodiesterase inhibitors potentiate statin‐induced cancer cell death

by Joseph Longo, Aleksandra A. Pandyra, Paweł Stachura, Mark D. Minden, Aaron D. Schimmer, Linda Z. Penn
Published 2020-10-01

A novel formulation of tigecycline has enhanced stability and sustained antibacterial and antileukemic activity.

by Yulia Jitkova, Marcela Gronda, Rose Hurren, Xiaoming Wang, Carolyn A Goard, Bozhena Jhas, Aaron D Schimmer
Published 2014-01-01

Correction: The Natural Pesticide Dihydrorotenone Induces Human Plasma Cell Apoptosis by Triggering Endoplasmic Reticulum Stress and Activating p38 Signaling Pathway.

by Jieyu Zhang, Juan Tang, Biyin Cao, Zubin Zhang, Jie Li, Aaron D Schimmer, Sudan He, Xinliang Mao
Published 2020-01-01

Transduction of Primary AML Cells with Lentiviral Vector for In Vitro Study or In Vivo Engraftment

by Aaron D. Schimmer, Rashim Pal Singh, Ayesh K. Seneviratne, Geethu E. Thomas, Neil MacLean, Rose Hurren
Published 2020-12-01

The natural pesticide dihydrorotenone induces human plasma cell apoptosis by triggering endoplasmic reticulum stress and activating p38 signaling pathway.

by Jieyu Zhang, Juan Tang, Biyin Cao, Zubin Zhang, Jie Li, Aaron D Schimmer, Sudan He, Xinliang Mao
Published 2013-01-01

Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma.

by Manujendra N Saha, Hua Jiang, Yijun Yang, Xiaoyun Zhu, Xiaoming Wang, Aaron D Schimmer, Lugui Qiu, Hong Chang
Published 2012-01-01

COVID‐19: a pandemic experience that illuminates potential reforms to health research

by Hannah N Kozlowski, Michael E Farkouh, Meredith S Irwin, Laszlo G Radvanyi, Aaron D Schimmer, Uri Tabori, Norman D Rosenblum
Published 2020-11-01

Glycogen synthase kinase-3 inhibition sensitizes pancreatic cancer cells to TRAIL-induced apoptosis.

by Shadi Mamaghani, Craig D Simpson, Pinjiang M Cao, May Cheung, Sue Chow, Bizhan Bandarchi, Aaron D Schimmer, David W Hedley
Published 2012-01-01

A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia.

by Aaron D Schimmer, Azra Raza, Thomas H Carter, David Claxton, Harry Erba, Daniel J DeAngelo, Martin S Tallman, Carolyn Goard, Gautam Borthakur
Published 2014-01-01

RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs.

by Tyler J W Robinson, Jeff C Liu, Frederick Vizeacoumar, Thomas Sun, Neil Maclean, Sean E Egan, Aaron D Schimmer, Alessandro Datti, Eldad Zacksenhaus
Published 2013-01-01

MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells

by Amir Bahat, Andres Goldman, Yehudit Zaltsman, Dilshad H. Khan, Coral Halperin, Emmanuel Amzallag, Vladislav Krupalnik, Michael Mullokandov, Alon Silberman, Ayelet Erez, Aaron D. Schimmer, Jacob H. Hanna, Atan Gross
Published 2018-12-01

Metabolic adaptation to chronic inhibition of mitochondrial protein synthesis in acute myeloid leukemia cells.

by Bozhena Jhas, Shrivani Sriskanthadevan, Marko Skrtic, Mahadeo A Sukhai, Veronique Voisin, Yulia Jitkova, Marcela Gronda, Rose Hurren, Rob C Laister, Gary D Bader, Mark D Minden, Aaron D Schimmer
Published 2013-01-01

Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism.

by Rida Mourtada, Sonali B Fonseca, Simon P Wisnovsky, Mark P Pereira, Xiaoming Wang, Rose Hurren, Jeremy Parfitt, Lesley Larsen, Robin A J Smith, Michael P Murphy, Aaron D Schimmer, Shana O Kelley
Published 2013-01-01

A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

by Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Published 2021-03-01

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

by Gregory A. Reed, Gary J. Schiller, Suman Kambhampati, Martin S. Tallman, Dan Douer, Mark D. Minden, Karen W. Yee, Vikas Gupta, Joseph Brandwein, Yulia Jitkova, Marcela Gronda, Rose Hurren, Aisha Shamas‐Din, Andre C. Schuh, Aaron D. Schimmer
Published 2016-11-01

Suppression of cancer progression by MGAT1 shRNA knockdown.

by Reza Beheshti Zavareh, Mahadeo A Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Craig D Simpson, Neil Maclean, Francis Zih, Troy Ketela, Carol J Swallow, Jason Moffat, David R Rose, Harry Schachter, Aaron D Schimmer, James W Dennis
Published 2012-01-01

Mutations in UBA3 confer resistance to the NEDD8-activating enzyme inhibitor MLN4924 in human leukemic cells.

by G Wei Xu, Julia I Toth, Sara R da Silva, Stacey-Lynn Paiva, Julie L Lukkarila, Rose Hurren, Neil Maclean, Mahadeo A Sukhai, Rabindra N Bhattacharjee, Carolyn A Goard, Bruno Medeiros, Patrick T Gunning, Sirano Dhe-Paganon, Matthew D Petroski, Aaron D Schimmer
Published 2014-01-01

Risk of Thrombosis in Adult Philadelphia-Positive ALL Treated with an Asparaginase-Free ALL Regimen

by Ruiqi Chen, Xing Liu, Arjun D. Law, Solaf Kanfar, Dawn Maze, Steven M. Chan, Vikas Gupta, Karen W. Yee, Mark D. Minden, Aaron D. Schimmer, Andre C. Schuh, Caroline J. McNamara, Tracy Murphy, Anna Xu, Umberto Falcone, Jack Seki, Hassan Sibai
Published 2021-12-01

A porphodimethene chemical inhibitor of uroporphyrinogen decarboxylase.

by Kenneth W Yip, Zhan Zhang, Noriko Sakemura-Nakatsugawa, Jui-Wen Huang, Nhu Mai Vu, Yi-Kun Chiang, Chih-Lung Lin, Jennifer Y Y Kwan, Shijun Yue, Yulia Jitkova, Terence To, Payam Zahedi, Emil F Pai, Aaron D Schimmer, Jonathan F Lovell, Jonathan L Sessler, Fei-Fei Liu
Published 2014-01-01