Efficacy of cyclooctadepsipeptides and aminophenylamidines against larval, immature and mature adult stages of a parasitologically characterized trichurosis model in mice.

by Daniel Kulke, Jürgen Krücken, Achim Harder, Georg von Samson-Himmelstjerna
Published 2014-02-01

SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.

by Claudia Welz, Nina Krüger, Monika Schniederjans, Sandra M Miltsch, Jürgen Krücken, Marcus Guest, Lindy Holden-Dye, Achim Harder, Georg von Samson-Himmelstjerna
Published 2011-04-01

The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.

by Anna Crisford, Ulrich Ebbinghaus-Kintscher, Eva Schoenhense, Achim Harder, Klaus Raming, Ita O'Kelly, Kelechi Ndukwe, Vincent O'Connor, Robert J Walker, Lindy Holden-Dye
Published 2015-01-01

Development of emodepside as a possible adulticidal treatment for human onchocerciasis-The fruit of a successful industrial-academic collaboration.

by Jürgen Krücken, Lindy Holden-Dye, Jennifer Keiser, Roger K Prichard, Simon Townson, Benjamin L Makepeace, Marc P Hübner, Steffen R Hahnel, Ivan Scandale, Achim Harder, Daniel Kulke
Published 2021-07-01

Characterization of the Ca2+-gated and voltage-dependent K+-channel Slo-1 of nematodes and its interaction with emodepside.

by Daniel Kulke, Georg von Samson-Himmelstjerna, Sandra M Miltsch, Adrian J Wolstenholme, Aaron R Jex, Robin B Gasser, Cristina Ballesteros, Timothy G Geary, Jennifer Keiser, Simon Townson, Achim Harder, Jürgen Krücken
Published 2014-12-01

Phylogenetic characterization of β-tubulins and development of pyrosequencing assays for benzimidazole resistance in cattle nematodes.

by Janina Demeler, Nina Krüger, Jürgen Krücken, Vera C von der Heyden, Sabrina Ramünke, Ursula Küttler, Sandra Miltsch, Michael López Cepeda, Malcolm Knox, Jozef Vercruysse, Peter Geldhof, Achim Harder, Georg von Samson-Himmelstjerna
Published 2013-01-01

Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside

by Marc P. Hübner, Simon Townson, Suzanne Gokool, Senyo Tagboto, Mary J. Maclean, Guilherme G. Verocai, Adrian J. Wolstenholme, Stefan J. Frohberger, Achim Hoerauf, Sabine Specht, Ivan Scandale, Achim Harder, Martin Glenschek-Sieberth, Steffen R. Hahnel, Daniel Kulke
Published 2021-12-01