Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice

by Jayagopi Surendar, Indulekha Karunakaran, Stefan J. Frohberger, Marianne Koschel, Achim Hoerauf, Achim Hoerauf, Marc P. Hübner
Published 2020-04-01

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils

by Stefan J. Frohberger, Jesuthas Ajendra, Jayagopi Surendar, Wiebke Stamminger, Alexandra Ehrens, Benedikt C. Buerfent, Katrin Gentil, Achim Hoerauf, Marc P. Hübner
Published 2019-05-01

IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation.

by Frédéric Fercoq, Estelle Remion, Stefan J Frohberger, Nathaly Vallarino-Lhermitte, Achim Hoerauf, John Le Quesne, Frédéric Landmann, Marc P Hübner, Leo M Carlin, Coralie Martin
Published 2019-08-01

Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis

by Jayagopi Surendar, Jayagopi Surendar, Stefan J. Frohberger, Indulekha Karunakaran, Vanessa Schmitt, Wiebke Stamminger, Anna-Lena Neumann, Christoph Wilhelm, Achim Hoerauf, Achim Hoerauf, Marc P. Hübner
Published 2019-10-01

S100A8/S100A9 deficiency increases neutrophil activation and protective immune responses against invading infective L3 larvae of the filarial nematode Litomosoides sigmodontis.

by Stefan J Frohberger, Frederic Fercoq, Anna-Lena Neumann, Jayagopi Surendar, Wiebke Stamminger, Alexandra Ehrens, Indulekha Karunakaran, Estelle Remion, Thomas Vogl, Achim Hoerauf, Coralie Martin, Marc P Hübner
Published 2020-02-01

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

by Marc P Hübner, Alexandra Ehrens, Marianne Koschel, Bettina Dubben, Franziska Lenz, Stefan J Frohberger, Sabine Specht, Ludo Quirynen, Sophie Lachau-Durand, Fetene Tekle, Benny Baeten, Marc Engelen, Charles D Mackenzie, Achim Hoerauf
Published 2019-01-01

Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside

by Marc P. Hübner, Simon Townson, Suzanne Gokool, Senyo Tagboto, Mary J. Maclean, Guilherme G. Verocai, Adrian J. Wolstenholme, Stefan J. Frohberger, Achim Hoerauf, Sabine Specht, Ivan Scandale, Achim Harder, Martin Glenschek-Sieberth, Steffen R. Hahnel, Daniel Kulke
Published 2021-12-01

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.

by Marc P Hübner, Coralie Martin, Sabine Specht, Marianne Koschel, Bettina Dubben, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Dominique Struever, Edward Mitre, Nathaly Vallarino-Lhermitte, Suzanne Gokool, Sara Lustigman, Manfred Schneider, Simon Townson, Achim Hoerauf, Ivan Scandale
Published 2020-07-01

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.

by Marc P Hübner, Marianne Koschel, Dominique Struever, Venelin Nikolov, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Thomas W von Geldern, Kennan Marsh, Joseph D Turner, Mark J Taylor, Stephen A Ward, Kenneth Pfarr, Dale J Kempf, Achim Hoerauf
Published 2019-08-01

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.

by Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Published 2020-01-01

Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

by Anna K. Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Tilman Aden, Stefan J. Frohberger, Álvaro López Mármol, Dnyaneshwar Kapote, Rolf Jansen, Lillibeth Chaverra-Muñoz, Marc P. Hübner, Kenneth Pfarr, Thomas Hesterkamp, Marc Stadler, Michael Gütschow, Gabriele M. König, Achim Hoerauf, Karl G. Wagner
Published 2020-11-01

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

by Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Published 2019-02-01

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

by Marc P. Hübner, Emma Gunderson, Ian Vogel, Christina A. Bulman, K.C. Lim, Marianne Koschel, Alexandra Ehrens, Stefan J. Frohberger, Martina Fendler, Nancy Tricoche, Denis Voronin, Andrew Steven, Victor Chi, Malina A. Bakowski, Ashley K. Woods, H. Michael Petrassi, Case W. McNamara, Brenda Beerntsen, Laura Chappell, William Sullivan, Mark J. Taylor, Joseph D. Turner, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari
Published 2020-04-01