Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice

by Jayagopi Surendar, Indulekha Karunakaran, Stefan J. Frohberger, Marianne Koschel, Achim Hoerauf, Achim Hoerauf, Marc P. Hübner
Published 2020-04-01

Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.

by Sabine Specht, Kenneth M Pfarr, Sandra Arriens, Marc P Hübner, Ute Klarmann-Schulz, Marianne Koschel, Sonja Sternberg, Coralie Martin, Louise Ford, Mark J Taylor, Achim Hoerauf
Published 2018-01-01

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.

by Marc P Hübner, Alexandra Ehrens, Marianne Koschel, Bettina Dubben, Franziska Lenz, Stefan J Frohberger, Sabine Specht, Ludo Quirynen, Sophie Lachau-Durand, Fetene Tekle, Benny Baeten, Marc Engelen, Charles D Mackenzie, Achim Hoerauf
Published 2019-01-01

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.

by Marc P Hübner, Coralie Martin, Sabine Specht, Marianne Koschel, Bettina Dubben, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Dominique Struever, Edward Mitre, Nathaly Vallarino-Lhermitte, Suzanne Gokool, Sara Lustigman, Manfred Schneider, Simon Townson, Achim Hoerauf, Ivan Scandale
Published 2020-07-01

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.

by Marc P Hübner, Marianne Koschel, Dominique Struever, Venelin Nikolov, Stefan J Frohberger, Alexandra Ehrens, Martina Fendler, Iliana Johannes, Thomas W von Geldern, Kennan Marsh, Joseph D Turner, Mark J Taylor, Stephen A Ward, Kenneth Pfarr, Dale J Kempf, Achim Hoerauf
Published 2019-08-01

Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.

by Andrea Schiefer, Marc P Hübner, Anna Krome, Christine Lämmer, Alexandra Ehrens, Tilman Aden, Marianne Koschel, Helene Neufeld, Lillibeth Chaverra-Muñoz, Rolf Jansen, Stefan Kehraus, Gabriele M König, Domen Pogorevc, Rolf Müller, Marc Stadler, Stephan Hüttel, Thomas Hesterkamp, Karl Wagner, Kenneth Pfarr, Achim Hoerauf
Published 2020-12-01

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.

by Alexandra Ehrens, Christopher S Lunde, Robert T Jacobs, Dominique Struever, Marianne Koschel, Stefan J Frohberger, Franziska Lenz, Martina Fendler, Joseph D Turner, Stephen A Ward, Mark J Taylor, Yvonne R Freund, Rianna Stefanakis, Eric Easom, Xianfeng Li, Jacob J Plattner, Achim Hoerauf, Marc P Hübner
Published 2020-01-01

Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.

by Thomas W von Geldern, Howard E Morton, Rick F Clark, Brian S Brown, Kelly L Johnston, Louise Ford, Sabine Specht, Robert A Carr, Deanne F Stolarik, Junli Ma, Matthew J Rieser, Dominique Struever, Stefan J Frohberger, Marianne Koschel, Alexandra Ehrens, Joseph D Turner, Marc P Hübner, Achim Hoerauf, Mark J Taylor, Stephen A Ward, Kennan Marsh, Dale J Kempf
Published 2019-02-01

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

by Marc P. Hübner, Emma Gunderson, Ian Vogel, Christina A. Bulman, K.C. Lim, Marianne Koschel, Alexandra Ehrens, Stefan J. Frohberger, Martina Fendler, Nancy Tricoche, Denis Voronin, Andrew Steven, Victor Chi, Malina A. Bakowski, Ashley K. Woods, H. Michael Petrassi, Case W. McNamara, Brenda Beerntsen, Laura Chappell, William Sullivan, Mark J. Taylor, Joseph D. Turner, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari
Published 2020-04-01