Hereditary Spastic Paraplegia: From Genes, Cells and Networks to Novel Pathways for Drug Discovery

by Alan Mackay-Sim
Published 2021-03-01

Directional Persistence of Cell Migration in Schizophrenia Patient-Derived Olfactory Cells

by Jing Yang Tee, Alan Mackay-Sim
Published 2021-08-01

Characterization of Olfactory Stem Cells

by Andrew Wetzig, Alan Mackay-Sim, Wayne Murrell
Published 2011-12-01

Patient-Derived Stem Cell Models in SPAST HSP: Disease Modelling and Drug Discovery

by Gautam Wali, Carolyn M. Sue, Alan Mackay-Sim
Published 2018-07-01

Leukaemia inhibitory factor stimulates proliferation of olfactory neuronal progenitors via inducible nitric oxide synthase.

by Estefania Lopez-Arenas, Alan Mackay-Sim, Juan Bacigalupo, Lorena Sulz
Published 2012-01-01

Could Cells from Your Nose Fix Your Heart? Transplantation of Olfactory Stem Cells in a Rat Model of Cardiac Infarction

by Cameron McDonald, Alan Mackay-Sim, Denis Crane, Wayne Murrell
Published 2010-01-01

Single cell morphology distinguishes genotype and drug effect in Hereditary Spastic Paraplegia

by Gautam Wali, Shlomo Berkovsky, Daniel R. Whiten, Alan Mackay-Sim, Carolyn M. Sue
Published 2021-08-01

Reprogramming of human olfactory neurosphere-derived cells from olfactory mucosal biopsies of a control cohort

by Hannah C. Leeson, Zoe Hunter, Harman Kaur Chaggar, Alan Mackay-Sim, Ernst J. Wolvetang
Published 2021-10-01

Oxidative Stress-Induced Axon Fragmentation Is a Consequence of Reduced Axonal Transport in Hereditary Spastic Paraplegia SPAST Patient Neurons

by Gautam Wali, Gautam Wali, Erandhi Liyanage, Nicholas F. Blair, Nicholas F. Blair, Ratneswary Sutharsan, Ratneswary Sutharsan, Jin-Sung Park, Jin-Sung Park, Alan Mackay-Sim, Alan Mackay-Sim, Carolyn M. Sue, Carolyn M. Sue
Published 2020-05-01

Transplantation of neuronal-primed human bone marrow mesenchymal stem cells in hemiparkinsonian rodents.

by Melissa L M Khoo, Helen Tao, Adrian C B Meedeniya, Alan Mackay-Sim, David D F Ma
Published 2011-01-01

Ataxia Telangiectasia iPSC line generated from a patient olfactory biopsy identifies novel disease-causing mutations

by Hannah C. Leeson, Zoe Hunter, Harman Kaur Chaggar, Martin F. Lavin, Alan Mackay-Sim, Ernst J. Wolvetang
Published 2021-10-01

Low dose tubulin-binding drugs rescue peroxisome trafficking deficit in patient-derived stem cells in Hereditary Spastic Paraplegia

by Yongjun Fan, Gautam Wali, Ratneswary Sutharsan, Bernadette Bellette, Denis I. Crane, Carolyn M. Sue, Alan Mackay-Sim
Published 2014-05-01

Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFβ-mediated axonogenesis.

by Shane Stegeman, Lachlan A Jolly, Susitha Premarathne, Jozef Gecz, Linda J Richards, Alan Mackay-Sim, Stephen A Wood
Published 2013-01-01

Mitochondrial Function in Hereditary Spastic Paraplegia: Deficits in SPG7 but Not SPAST Patient-Derived Stem Cells

by Gautam Wali, Gautam Wali, Kishore Raj Kumar, Kishore Raj Kumar, Kishore Raj Kumar, Kishore Raj Kumar, Kishore Raj Kumar, Erandhi Liyanage, Ryan L. Davis, Ryan L. Davis, Ryan L. Davis, Alan Mackay-Sim, Alan Mackay-Sim, Carolyn M. Sue, Carolyn M. Sue, Carolyn M. Sue
Published 2020-08-01

Multipotent human stromal cells isolated from cord blood, term placenta and adult bone marrow show distinct differences in gene expression pattern

by Nicholas Matigian, Gary Brooke, Faten Zaibak, Tony Rossetti, Katarina Kollar, Rebecca Pelekanos, Celena Heazlewood, Alan Mackay-Sim, Christine A. Wells, Kerry Atkinson
Published 2015-03-01

A cross-study transcriptional analysis of Parkinson's disease.

by Greg T Sutherland, Nicholas A Matigian, Alistair M Chalk, Matthew J Anderson, Peter A Silburn, Alan Mackay-Sim, Christine A Wells, George D Mellick
Published 2009-01-01

DNA methylation in schizophrenia in different patient-derived cell types

by Alejandra M. Vitale, Nicholas A. Matigian, Alexandre S. Cristino, Katia Nones, Sugandha Ravishankar, Bernadette Bellette, Yongjun Fan, Stephen A. Wood, Ernst Wolvetang, Alan Mackay-Sim
Published 2017-01-01

A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations

by Greger Abrahamsen, Yongjun Fan, Nicholas Matigian, Gautam Wali, Bernadette Bellette, Ratneswary Sutharsan, Jyothy Raju, Stephen A. Wood, David Veivers, Carolyn M. Sue, Alan Mackay-Sim
Published 2013-03-01

A patient-derived stem cell model of hereditary spastic paraplegia with SPAST mutations

by Greger Abrahamsen, Yongjun Fan, Nicholas Matigian, Gautam Wali, Bernadette Bellette, Ratneswary Sutharsan, Jyothy Raju, Stephen A. Wood, David Veivers, Carolyn M. Sue, Alan Mackay-Sim
Published 2015-10-01

Variance of gene expression identifies altered network constraints in neurological disease.

by Jessica C Mar, Nicholas A Matigian, Alan Mackay-Sim, George D Mellick, Carolyn M Sue, Peter A Silburn, John J McGrath, John Quackenbush, Christine A Wells
Published 2011-08-01