Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.

by Marie-Jo Halaby, Anne Hakem, Li Li, Samah El Ghamrasni, Shriram Venkatesan, Prakash M Hande, Otto Sanchez, Razqallah Hakem
Published 2013-01-01

Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome.

by Toshiyuki Bohgaki, Miyuki Bohgaki, Renato Cardoso, Stephanie Panier, Dimphy Zeegers, Li Li, Grant S Stewart, Otto Sanchez, M Prakash Hande, Daniel Durocher, Anne Hakem, Razqallah Hakem
Published 2011-04-01

Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.

by Samah El Ghamrasni, Ashwin Pamidi, Marie Jo Halaby, Miyuki Bohgaki, Renato Cardoso, Li Li, Shriram Venkatesan, Swaminathan Sethu, Atsushi Hirao, Tak W Mak, Manoor Prakash Hande, Anne Hakem, Razqallah Hakem
Published 2011-05-01

RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation

by Kiran Kumar Naidu Guturi, Miyuki Bohgaki, Toshiyuki Bohgaki, Tharan Srikumar, Deborah Ng, Ramya Kumareswaran, Samah El Ghamrasni, Justin Jeon, Parasvi Patel, Mohamed Saad Eldin, Rob Bristow, Peter Cheung, Grant S. Stewart, Brian Raught, Anne Hakem, Razqallah Hakem
Published 2016-08-01

Role of Pirh2 in mediating the regulation of p53 and c-Myc.

by Anne Hakem, Miyuki Bohgaki, Bénédicte Lemmers, Elisabeth Tai, Leonardo Salmena, Elzbieta Matysiak-Zablocki, Yong-Sam Jung, Jana Karaskova, Lilia Kaustov, Shili Duan, Jason Madore, Paul Boutros, Yi Sheng, Marta Chesi, P Leif Bergsagel, Bayardo Perez-Ordonez, Anne-Marie Mes-Masson, Linda Penn, Jeremy Squire, Xinbin Chen, Igor Jurisica, Cheryl Arrowsmith, Otto Sanchez, Samuel Benchimol, Razqallah Hakem
Published 2011-11-01