Validation of Babesia proteasome as a drug target

by Marie Jalovecka, David Hartmann, Yukiko Miyamoto, Lars Eckmann, Ondrej Hajdusek, Anthony J. O'Donoghue, Daniel Sojka
Published 2018-12-01

Activity profiling of peptidases in Angiostrongylus costaricensis first-stage larvae and adult worms.

by Karina M Rebello, James H McKerrow, Ester M Mota, Anthony J O Donoghue, Ana Gisele C Neves-Ferreira
Published 2018-10-01

Cysteine and Aspartyl Proteases Contribute to Protein Digestion in the Gut of Freshwater Planaria.

by Louise S Goupil, Sam L Ivry, Ivy Hsieh, Brian M Suzuki, Charles S Craik, Anthony J O'Donoghue, James H McKerrow
Published 2016-08-01

Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystati...

by Hana Dvořáková, Roman Leontovyč, Tomáš Macháček, Anthony J. O'Donoghue, Ondřej Šedo, Zbyněk Zdráhal, Charles S. Craik, Conor R. Caffrey, Petr Horák, Libor Mikeš
Published 2020-02-01

Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase.

by Anthony J O'Donoghue, Ye Jin, Giselle M Knudsen, Natascha C Perera, Dieter E Jenne, John E Murphy, Charles S Craik, Terry W Hermiston
Published 2013-01-01

Integrated Activity and Genetic Profiling of Secreted Peptidases in Cryptococcus neoformans Reveals an Aspartyl Peptidase Required for Low pH Survival and Virulence.

by Starlynn C Clarke, Phillip A Dumesic, Christina M Homer, Anthony J O'Donoghue, Florencia La Greca, Lenka Pallova, Pavel Majer, Hiten D Madhani, Charles S Craik
Published 2016-12-01

The Pseudomonas aeruginosa protease LasB directly activates IL-1β

by Josh Sun, Doris L. LaRock, Elaine A. Skowronski, Jacqueline M. Kimmey, Joshua Olson, Zhenze Jiang, Anthony J. O'Donoghue, Victor Nizet, Christopher N. LaRock
Published 2020-10-01

Molecular characterization and functional analysis of the Schistosoma mekongi Ca2+-dependent cysteine protease (calpain)

by Salisa Chaimon, Yanin Limpanont, Onrapak Reamtong, Sumate Ampawong, Orawan Phuphisut, Phiraphol Chusongsang, Jiraporn Ruangsittichai, Usa Boonyuen, Dorn Watthanakulpanich, Anthony J. O’Donoghue, Conor R. Caffrey, Poom Adisakwattana
Published 2019-07-01

High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma

by Elisa Maffioli, Zhenze Jiang, Simona Nonnis, Armando Negri, Valentina Romeo, Christopher B. Lietz, Vivian Hook, Giuseppe Ristagno, Giuseppe Baselli, Erik B. Kistler, Federico Aletti, Anthony J. O’Donoghue, Gabriella Tedeschi
Published 2020-09-01

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties.

by Adrian Leontovyč, Lenka Ulrychová, Anthony J O'Donoghue, Jiří Vondrášek, Lucie Marešová, Martin Hubálek, Pavla Fajtová, Marta Chanová, Zhenze Jiang, Charles S Craik, Conor R Caffrey, Michael Mareš, Jan Dvořák, Martin Horn
Published 2018-04-01

Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica.

by Ileana Corvo, Anthony J O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Alegra Eroy-Reveles, Leda Roche, James H McKerrow, John P Dalton, Charles S Craik, Conor R Caffrey, José F Tort
Published 2013-01-01

Immunoproteasome functions explained by divergence in cleavage specificity and regulation

by Michael B Winter, Florencia La Greca, Shirin Arastu-Kapur, Francesco Caiazza, Peter Cimermancic, Tonia J Buchholz, Janet L Anderl, Matthew Ravalin, Markus F Bohn, Andrej Sali, Anthony J O'Donoghue, Charles S Craik
Published 2017-11-01

Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L

by Ileana Corvo, Florencia Ferraro, Alicia Merlino, Kathrin Zuberbühler, Anthony J. O'Donoghue, Lucía Pastro, Natalia Pi-Denis, Tatiana Basika, Leda Roche, James H. McKerrow, Charles S. Craik, Conor R. Caffrey, José F. Tort
Published 2018-04-01

Neutrophilic proteolysis in the cystic fibrosis lung correlates with a pathogenic microbiome

by Robert A. Quinn, Sandeep Adem, Robert H. Mills, William Comstock, Lindsay DeRight Goldasich, Gregory Humphrey, Alexander A. Aksenov, Alexei V. Melnik, Ricardo da Silva, Gail Ackermann, Nuno Bandeira, David J. Gonzalez, Doug Conrad, Anthony J. O’Donoghue, Rob Knight, Pieter C. Dorrestein
Published 2019-02-01