Efficacy of a Covalent Microtubule Stabilizer in Taxane-Resistant Ovarian Cancer Models

by Samantha S. Yee, April L. Risinger
Published 2021-07-01

Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

by Lin Du, Samantha S. Yee, Karthik Ramachandran, April L. Risinger
Published 2020-01-01

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

by Peter M LoCoco, April L Risinger, Hudson R Smith, Teresa S Chavera, Kelly A Berg, William P Clarke
Published 2017-11-01

Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

by Cristina C. Rohena, April L. Risinger, Ravi Kumar Vyas Devambatla, Nicholas F. Dybdal-Hargreaves, Roma Kaul, Shruti Choudhary, Aleem Gangjee, Susan L. Mooberry
Published 2016-12-01

Didemnaketals F and G, New Bioactive Spiroketals from a Red Sea Ascidian Didemnum Species

by Lamiaa A. Shaala, Diaa T.A. Youssef, Sabrin R.M. Ibrahim, Gamal A. Mohamed, Jihan M. Badr, April L. Risinger, Susan L. Mooberry
Published 2014-09-01

Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential

by Charles S. Fermaintt, Thilini Peramuna, Shengxin Cai, Leila Takahashi-Ruiz, Jacob Nathaniel Essif, Corena V. Grant, Barry R. O’Keefe, Susan L. Mooberry, Robert H. Cichewicz, April L. Risinger
Published 2021-06-01

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

by Francisco de Asís Balaguer, Tobias Mühlethaler, Juan Estévez-Gallego, Enrique Calvo, Juan Francisco Giménez-Abián, April L. Risinger, Erik J. Sorensen, Christopher D. Vanderwal, Karl-Heinz Altmann, Susan L. Mooberry, Michel O. Steinmetz, María Ángela Oliva, Andrea E. Prota, J. Fernando Díaz
Published 2019-03-01