Direct nose to brain delivery of small molecules: critical analysis of data from a standardized in vivo screening model in rats

by Deborah Dhuyvetter, Fetene Tekle, Maxim Nazarov, Rob J. Vreeken, Herman Borghys, Frederik Rombouts, Ilse Lenaerts, Astrid Bottelbergs
Published 2020-01-01

Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation

by Simon Verheijden, Astrid Bottelbergs, Olga Krysko, Dmitri V. Krysko, Lien Beckers, Stephanie De Munter, Paul P. Van Veldhoven, Sabine Wyns, Wim Kulik, Klaus-Armin Nave, Matt S. Ramer, Peter Carmeliet, Celia M. Kassmann, Myriam Baes
Published 2013-10-01

CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia

by Chritica Lodder, Isabelle Scheyltjens, Ilie Cosmin Stancu, Pablo Botella Lucena, Manuel Gutiérrez de Ravé, Sarah Vanherle, Tim Vanmierlo, Niels Cremers, Hannah Vanrusselt, Bert Brône, Bernard Hanseeuw, Jean-Noël Octave, Astrid Bottelbergs, Kiavash Movahedi, Ilse Dewachter
Published 2021-06-01

Passive immunotherapy with a novel antibody against 3pE-modified Aβ demonstrates potential for enhanced efficacy and favorable safety in combination with BACE inhibitor treatment i...

by Jonathan Janssens, Bart Hermans, Marc Vandermeeren, Erio Barale-Thomas, Marianne Borgers, Roland Willems, Greet Meulders, Cindy Wintmolders, Dries Van den Bulck, Astrid Bottelbergs, Luc Ver Donck, Peter Larsen, Dieder Moechars, Wilson Edwards, Marc Mercken, Bianca Van Broeck
Published 2021-07-01

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

by Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A. Kemp, Marc Mercken, Kurt R. Brunden, John Q. Trojanowski, Ilse Dewachter, Virginia M.Y. Lee, Diederik Moechars
Published 2015-01-01

Diffusion kurtosis imaging allows the early detection and longitudinal follow-up of amyloid-β-induced pathology

by Jelle Praet, Nikolay V. Manyakov, Leacky Muchene, Zhenhua Mai, Vasilis Terzopoulos, Steve de Backer, An Torremans, Pieter-Jan Guns, Tom Van De Casteele, Astrid Bottelbergs, Bianca Van Broeck, Jan Sijbers, Dirk Smeets, Ziv Shkedy, Luc Bijnens, Darrel J. Pemberton, Mark E. Schmidt, Annemie Van der Linden, Marleen Verhoye
Published 2018-01-01

Comparison of New Tau PET-Tracer Candidates With [F]T808 and [F]T807

by Lieven Declercq Pharmacist, Sofie Celen PhD, Joan Lecina PhD, Muneer Ahamed PhD, Thomas Tousseyn Prof, MD, PhD, Diederik Moechars PhD, Jesus Alcazar PhD, Manuela Ariza PhD, Katleen Fierens PhD, Astrid Bottelbergs PhD, Jonas Mariën PhD, Rik Vandenberghe Prof, MD, PhD, Ignacio Jose Andres PhD, Koen Van Laere Prof, MD, PhD, Alfons Verbruggen Prof, PhD, Guy Bormans Prof, PhD
Published 2016-01-01