A combination approach of pseudotime analysis and mathematical modeling for understanding drug-resistant mechanisms

by Shigeyuki Magi, Sewon Ki, Masao Ukai, Elisa Domínguez-Hüttinger, Atsuhiko T Naito, Yutaka Suzuki, Mariko Okada
Published 2021-09-01

Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjec...

by Ai Goto, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama
Published 2018-06-01

Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blocker...

by Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Atsuhiko T. Naito, Ai Goto, Koki Chiba, Yuko Sekino, Yasunari Kanda, Atsushi Sugiyama
Published 2018-08-01

Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs

by Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Hiroko Izumi-Nakaseko
Published 2019-03-01

Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector...

by Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Atsuhiko T. Naito, Yasunari Kanda, Akio Matsumoto, Hiroko Izumi-Nakaseko
Published 2019-08-01

Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets

by Hiroko Izumi-Nakaseko, Yasunari Kanda, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Takeshi Wada, Kentaro Ando, Atsuhiko T. Naito, Yuko Sekino, Atsushi Sugiyama
Published 2017-09-01

Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs

by Koki Chiba, Takeshi Wada, Yuji Nakamura, Xin Cao, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Koichiro Tanaka, Atsuhiko T. Naito, Atsushi Sugiyama
Published 2017-08-01

Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death

by Ai Goto, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kumiko Kitta, Kiyotaka Hoshiai, Koki Chiba, Kentaro Ando, Yasuki Akie, Atsuhiko T. Naito, Atsushi Sugiyama
Published 2018-11-01

Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction.

by Masato Kanda, Toshio Nagai, Toshinao Takahashi, Mei Lan Liu, Naomichi Kondou, Atsuhiko T Naito, Hiroshi Akazawa, Goro Sashida, Atsushi Iwama, Issei Komuro, Yoshio Kobayashi
Published 2016-01-01

Gremlin enhances the determined path to cardiomyogenesis.

by Daisuke Kami, Ichiro Shiojima, Hatsune Makino, Kenji Matsumoto, Yoriko Takahashi, Ryuga Ishii, Atsuhiko T Naito, Masashi Toyoda, Hirohisa Saito, Masatoshi Watanabe, Issei Komuro, Akihiro Umezawa
Published 2008-06-01

Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs

by Kentaro Ando, Akira Takahara, Yuji Nakamura, Takeshi Wada, Koki Chiba, Ai Goto, Nur Jaharat Lubna, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kiyotaka Hoshiai, Yasuki Akie, Atsuhiko T. Naito, Atsushi Sugiyama
Published 2018-02-01

Effects of moxifloxacin on the proarrhythmic surrogate markers in healthy Filipino subjects: Exposure-response modeling using ECG data of thorough QT/QTc study

by Suchitra Matsukura, Yuji Nakamura, Kiyotaka Hoshiai, Takashi Hayashi, Tadashi Koga, Ai Goto, Koki Chiba, Nur Jaharat Lubna, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama
Published 2018-04-01

Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes

by Hideki Yasutake, Jong-Kook Lee, Akihito Hashimoto, Kiyoshi Masuyama, Jun Li, Yuki Kuramoto, Shuichiro Higo, Shungo Hikoso, Kyoko Hidaka, Atsuhiko T. Naito, Shigeru Miyagawa, Yoshiki Sawa, Issei Komuro, Yasushi Sakata
Published 2021-05-01

Optimizing the Direction and Order of the Motion Unveiled the Ability of Conventional Monolayers of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Show Frequency-Dep...

by Hiroko Izumi-Nakaseko, Koki Chiba, Mihoko Hagiwara-Nagasawa, Ayano Satsuka, Ai Goto, Yoshio Nunoi, Ryuichi Kambayashi, Akio Matsumoto, Yoshinori Takei, Yasunari Kanda, Atsuhiko T. Naito, Atsushi Sugiyama, Atsushi Sugiyama, Atsushi Sugiyama
Published 2020-09-01

Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure

by Toshihiro Yamaguchi, Tomokazu S. Sumida, Seitaro Nomura, Masahiro Satoh, Tomoaki Higo, Masamichi Ito, Toshiyuki Ko, Kanna Fujita, Mary E. Sweet, Atsushi Sanbe, Kenji Yoshimi, Ichiro Manabe, Toshikuni Sasaoka, Matthew R. G. Taylor, Haruhiro Toko, Eiki Takimoto, Atsuhiko T. Naito, Issei Komuro
Published 2020-08-01

DNA single-strand break-induced DNA damage response causes heart failure

by Tomoaki Higo, Atsuhiko T. Naito, Tomokazu Sumida, Masato Shibamoto, Katsuki Okada, Seitaro Nomura, Akito Nakagawa, Toshihiro Yamaguchi, Taku Sakai, Akihito Hashimoto, Yuki Kuramoto, Masamichi Ito, Shungo Hikoso, Hiroshi Akazawa, Jong-Kook Lee, Ichiro Shiojima, Peter J. McKinnon, Yasushi Sakata, Issei Komuro
Published 2017-04-01

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

by Seitaro Nomura, Masahiro Satoh, Takanori Fujita, Tomoaki Higo, Tomokazu Sumida, Toshiyuki Ko, Toshihiro Yamaguchi, Takashige Tobita, Atsuhiko T. Naito, Masamichi Ito, Kanna Fujita, Mutsuo Harada, Haruhiro Toko, Yoshio Kobayashi, Kaoru Ito, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Hiroyuki Aburatani, Issei Komuro
Published 2018-10-01

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure.

by Takehiro Kamo, Hiroshi Akazawa, Wataru Suda, Akiko Saga-Kamo, Yu Shimizu, Hiroki Yagi, Qing Liu, Seitaro Nomura, Atsuhiko T Naito, Norifumi Takeda, Mutsuo Harada, Haruhiro Toko, Hidetoshi Kumagai, Yuichi Ikeda, Eiki Takimoto, Jun-Ichi Suzuki, Kenya Honda, Hidetoshi Morita, Masahira Hattori, Issei Komuro
Published 2017-01-01