Article Computational Biology Humans Mutation biology evolution genetics human mutation Algorithms Anti-Infective Agents Antineoplastic Agents Bourque distances Computer Simulation Disease Progression Dose-Response Relationship, Drug Drug Resistance, Microbial Drug Resistance, Neoplasm Evolution, Molecular Host Microbial Interactions Labeled phylogenetic trees Leukemia, Myeloid, Acute Markov chain Models, Biological Models, Statistical Mutation Rate Mutation trees Neoplasms Phenotype Robinson−Foulds distance