Vaccination with <i>Schistosoma mansoni</i> Cholinesterases Reduces the Parasite Burden and Egg Viability in a Mouse Model of Schistosomiasis

by Bemnet A. Tedla, Darren Pickering, Luke Becker, Alex Loukas, Mark S. Pearson
Published 2020-04-01

Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signalling and drug detoxification and are essential for parasite survival.

by Bemnet A Tedla, Javier Sotillo, Darren Pickering, Ramon M Eichenberger, Stephanie Ryan, Luke Becker, Alex Loukas, Mark S Pearson
Published 2019-12-01

<i>Schistosoma Haematobium</i> Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis

by Gebeyaw G. Mekonnen, Bemnet A. Tedla, Darren Pickering, Luke Becker, Lei Wang, Bin Zhan, Maria Elena Bottazzi, Alex Loukas, Javier Sotillo, Mark S. Pearson
Published 2020-07-01

Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases.

by Madhu K Sundaraneedi, Bemnet A Tedla, Ramon M Eichenberger, Luke Becker, Darren Pickering, Michael J Smout, Siji Rajan, Phurpa Wangchuk, F Richard Keene, Alex Loukas, J Grant Collins, Mark S Pearson
Published 2017-12-01

Immunomics-Guided Antigen Discovery for Praziquantel-Induced Vaccination in Urogenital Human Schistosomiasis

by Mark S. Pearson, Bemnet A. Tedla, Luke Becker, Rie Nakajima, Al Jasinskas, Takafira Mduluza, Takafira Mduluza, Francisca Mutapi, Francisca Mutapi, Claude Oeuvray, Beatrice Greco, Javier Sotillo, Javier Sotillo, Philip L. Felgner, Alex Loukas
Published 2021-05-01