Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L × GSK3β mice by delaying brainstem tauopathy

by Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver, Hervé Maurin, Fred Van Leuven
Published 2014-07-01

Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.

by Hervé Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski, Mathias V Schmidt, Sebastian Kuegler, Fred Van Leuven
Published 2013-01-01

Syntenin-knock out reduces exosome turnover and viral transduction

by Rudra Kashyap, Marielle Balzano, Benoit Lechat, Kathleen Lambaerts, Antonio Luis Egea-Jimenez, Frédérique Lembo, Joanna Fares, Sofie Meeussen, Sebastian Kügler, Anton Roebroek, Guido David, Pascale Zimmermann
Published 2021-02-01

AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.

by Tomasz Jaworski, Ilse Dewachter, Benoit Lechat, Sophie Croes, Annelies Termont, David Demedts, Peter Borghgraef, Herman Devijver, Robert K Filipkowski, Leszek Kaczmarek, Sebastian Kügler, Fred Van Leuven
Published 2009-10-01

Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.

by Hervé Maurin, Seon-Ah Chong, Igor Kraev, Heather Davies, Anna Kremer, Claire Marie Seymour, Benoit Lechat, Tomasz Jaworski, Peter Borghgraef, Herman Devijver, Geert Callewaert, Michael G Stewart, Fred Van Leuven
Published 2014-01-01

Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain

by Jan R. Detrez, Hervé Maurin, Kristof Van Kolen, Roland Willems, Julien Colombelli, Benoit Lechat, Bart Roucourt, Fred Van Leuven, Sarah Baatout, Peter Larsen, Rony Nuydens, Jean-Pierre Timmermans, Winnok H. De Vos
Published 2019-07-01

GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylationResearch in context

by Malgorzata Urbanska, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Bartosz Caban, Karolina Nader, Barbara Pijet, Katarzyna Kalita, Agata Gozdz, Herman Devijver, Benoit Lechat, Tomasz Jaworski, Wieslawa Grajkowska, Krzysztof Sadowski, Sergiusz Jozwiak, Katarzyna Kotulska, Jan Konopacki, Fred Van Leuven, Erwin A. van Vliet, Eleonora Aronica, Jacek Jaworski
Published 2019-01-01