Duvelisib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Phosphoinositide 3-Kinases

by Daniel A. Rodrigues, Fernanda S. Sagrillo, Carlos A. M. Fraga
Published 2019-05-01

Síntese de β-cetoésteres cíclicos: novo procedimento para ciclizações de Dieckmann empregando ALCL3 e trietilamina Synthesis of β-keto esters: new easy procedure for diec...

by Emerson P. Peçanha, Eliezer J. Barreiro, Carlos A. M. Fraga
Published 1997-08-01

A química medicinal de N-acilidrazonas: novos compostos-protótipos de fármacos analgésicos, antiinflamatórios e anti-trombóticos Medicinal chemistry of N-acylhydrazones: novel lead...

by Eliezer J. Barreiro, Carlos A. M. Fraga, Ana L. P. Miranda, Carlos R. Rodrigues
Published 2002-02-01

MAOS and Medicinal Chemistry: Some Important Examples from the Last Years

by Carlos A. M. Fraga, Nailton M. Nascimento-Júnior, Arthur E. Kümmerle, Eliezer J. Barreiro
Published 2011-11-01

Discovery of Novel Orally Active Tetrahydro-Naphthyl-N-Acylhydrazones with In Vivo Anti-TNF-α Effect and Remarkable Anti-Inflammatory Properties.

by Natália M Cordeiro, Rosana H C N Freitas, Carlos A M Fraga, Patricia D Fernandes
Published 2016-01-01

(2E)-N′-[(E)-4-Chlorobenzylidene]-3-phenylprop-2-enohydrazide monohydrate

by Samir A. Carvalho, Edson F. da Silva, Carlos A. M. Fraga, Solange M. S. V. Wardell, James L. Wardell, Edward R. T. Tiekink
Published 2010-09-01

(2E)-N′-[(E)-2-Hydroxybenzylidene]-3-phenylprop-2-enohydrazide

by Samir A. Carvalho, Edson F. da Silva, Carlos A. M. Fraga, Solange M. S. V. Wardell, James L. Wardell, Edward R. T. Tiekink
Published 2012-07-01

(2E)-N′-[(E)-Benzylidene]-3-phenylprop-2-enohydrazide from synchrotron radiation

by Samir A. Carvalho, Edson F. da Silva, Carlos A. M. Fraga, Solange M. S. V. Wardell, James L. Wardell, Edward R. T. Tiekink
Published 2012-07-01

1-Methyl-7-(4-nitrophenyl)-3-phenylpyrazolo[3,4-b]pyrrolo[3,4-d]pyridine-6,8(3H,7H)-dione

by Ricardo Menegatti, Valéria de Oliveira, Eliezer J. Barreiro, Carlos A. M. Fraga, Cecília M. A. Oliveira, Jose R. Sabino
Published 2008-12-01

Novel potent imidazo[1,2-a]pyridine-N-Glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies.

by Renata B Lacerda, Natália M Sales, Leandro L da Silva, Roberta Tesch, Ana Luisa P Miranda, Eliezer J Barreiro, Patricia D Fernandes, Carlos A M Fraga
Published 2014-01-01

Discovery of novel orally active anti-inflammatory N-phenylpyrazolyl-N-glycinyl-hydrazone derivatives that inhibit TNF-α production.

by Renata B Lacerda, Leandro L da Silva, Cleverton K F de Lima, Eduardo Miguez, Ana Luisa P Miranda, Stefan A Laufer, Eliezer J Barreiro, Carlos A M Fraga
Published 2012-01-01

Different molecular conformations in the crystal structures of three 5-nitroimidazolyl derivatives

by Luis F. B. Osorio, Samir A. Carvalho, Edson F. da Silva, Carlos A. M. Fraga, Solange M. S. V. Wardell, Bruce F. Milne, James L. Wardell, William T. A. Harrison
Published 2018-03-01

Evaluation of Functional Selectivity of Haloperidol, Clozapine, and LASSBio-579, an Experimental Compound With Antipsychotic-Like Actions in Rodents, at G Protein and Arrestin Sign...

by Rafaela R. Silva, Lucas T. Parreiras-e-Silva, Thais E.T. Pompeu, Diego A. Duarte, Carlos A.M. Fraga, Eliezer J. Barreiro, Ricardo Menegatti, Claudio M. Costa-Neto, François Noël
Published 2019-06-01

Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives

by Rosana H.C.N. Freitas, Juliana M.C. Barbosa, Patrícia Bernardino, Vitor Sueth-Santiago, Solange M.S.V. Wardell, James L. Wardell, Débora Decoté-Ricardo, Tatiana G. Melo, Edson F. da Silva, Kelly Salomão, Carlos A.M. Fraga
Published 2020-07-01

Design, Synthesis, Experimental and Theoretical Characterization of a New Multitarget 2-Thienyl-<i>N</i>-Acylhydrazone Derivative

by Isadora T. S. Bastos, Pedro de Sena M. Pinheiro, Fanny N. Costa, Miguel D. Rocha, Carlos Mauricio R. Sant’Anna, Delson Braz, Everton T. Souza, Marco A. Martins, Eliezer J. Barreiro, Fabio F. Ferreira, Regina C. Barroso, Carlos A. M. Fraga
Published 2018-11-01

LASSBio-1135: a dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain.

by Cleverton K F Lima, Rafael M Silva, Renata B Lacerda, Bruna L R Santos, Rafaela V Silva, Luciana S Amaral, Luís E M Quintas, Carlos A M Fraga, Eliezer J Barreiro, Marília Z P Guimaraes, Ana L P Miranda
Published 2014-01-01

LASSBio-897 Reduces Lung Injury Induced by Silica Particles in Mice: Potential Interaction with the A2A Receptor

by Vinicius F. Carvalho, Tatiana P. T. Ferreira, Ana C. S. de Arantes, François Noël, François Noël, Roberta Tesch, Roberta Tesch, Carlos M. R. Sant’Anna, Eliezer J. L. Barreiro, Eliezer J. L. Barreiro, Carlos A. M. Fraga, Patrícia M. Rodrigues e Silva, Patrícia M. Rodrigues e Silva, Marco A. Martins, Marco A. Martins
Published 2017-10-01