Versatility of Approximating Single-Particle Electron Microscopy Density Maps Using Pseudoatoms and Approximation-Accuracy Control

by Slavica Jonić, Carlos Oscar S. Sorzano
Published 2016-01-01

3DCONS-DB: A Database of Position-Specific Scoring Matrices in Protein Structures

by Ruben Sanchez-Garcia, Carlos Oscar Sanchez Sorzano, Jose Maria Carazo, Joan Segura
Published 2017-12-01

FlexAlign: An Accurate and Fast Algorithm for Movie Alignment in Cryo-Electron Microscopy

by David Střelák, Jiří Filipovič, Amaya Jiménez-Moreno, Jose María Carazo, Carlos Óscar S. Sorzano
Published 2020-06-01

Improving Adaptive and Memory Immune Responses of an HIV/AIDS Vaccine Candidate MVA-B by Deletion of Vaccinia Virus Genes (C6L and K7R) Blocking Interferon Signaling Pathways.

by Juan García-Arriaza, Pilar Arnáez, Carmen E Gómez, Carlos Óscar S Sorzano, Mariano Esteban
Published 2013-01-01

DeepRes: a new deep-learning- and aspect-based local resolution method for electron-microscopy maps

by Erney Ramírez-Aportela, Javier Mota, Pablo Conesa, Jose Maria Carazo, Carlos Oscar S. Sorzano
Published 2019-11-01

Immune Modulation of NYVAC-Based HIV Vaccines by Combined Deletion of Viral Genes that Act on Several Signalling Pathways

by Carmen Elena Gómez, Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Oscar S. Sorzano, Mariano Esteban
Published 2017-12-01

Deep Consensus, a deep learning-based approach for particle pruning in cryo-electron microscopy

by Ruben Sanchez-Garcia, Joan Segura, David Maluenda, Jose Maria Carazo, Carlos Oscar S. Sorzano
Published 2018-11-01

Measuring local-directional resolution and local anisotropy in cryo-EM maps

by Jose Luis Vilas, Hemant D. Tagare, Javier Vargas, Jose Maria Carazo, Carlos Oscar S. Sorzano
Published 2020-01-01

Immunogenic profiling in mice of a HIV/AIDS vaccine candidate (MVA-B) expressing four HIV-1 antigens and potentiation by specific gene deletions.

by Juan García-Arriaza, José Luis Nájera, Carmen E Gómez, Carlos Oscar S Sorzano, Mariano Esteban
Published 2010-01-01

High quality long-term CD4+ and CD8+ effector memory populations stimulated by DNA-LACK/MVA-LACK regimen in Leishmania major BALB/c model of infection.

by Lucas Sánchez-Sampedro, Carmen Elena Gómez, Ernesto Mejías-Pérez, Carlos Oscar S Sorzano, Mariano Esteban
Published 2012-01-01

DeepEMhancer: a deep learning solution for cryo-EM volume post-processing

by Ruben Sanchez-Garcia, Josue Gomez-Blanco, Ana Cuervo, Jose Maria Carazo, Carlos Oscar S. Sorzano, Javier Vargas
Published 2021-07-01

Removal of the C6 Vaccinia Virus Interferon-β Inhibitor in the Hepatitis C Vaccine Candidate MVA-HCV Elicited in Mice High Immunogenicity in Spite of Reduced Host Gene Expression

by María Q. Marín, Patricia Pérez, Carmen E. Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Juan García-Arriaza
Published 2018-08-01

A Novel MVA-Based HIV Vaccine Candidate (MVA-gp145-GPN) Co-Expressing Clade C Membrane-Bound Trimeric gp145 Env and Gag-Induced Virus-Like Particles (VLPs) Triggered Broad and Mult...

by Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Oscar S. Sorzano, Lidia Saiz, Pilar Mediavilla, Mariano Esteban, Carmen Elena Gómez
Published 2019-02-01

Induction of Broad and Polyfunctional HIV-1-Specific T Cell Responses by the Multiepitopic Protein TMEP-B Vectored by MVA Virus

by Beatriz Perdiguero, Cristina Sánchez-Corzo, Carlos Oscar S. Sorzano, Pilar Mediavilla, Lidia Saiz, Mariano Esteban, Carmen Elena Gómez
Published 2019-06-01

A human multi-epitope recombinant vaccinia virus as a universal T cell vaccine candidate against influenza virus.

by Alan G Goodman, Paul P Heinen, Susana Guerra, Aneesh Vijayan, Carlos Oscar S Sorzano, Carmen E Gomez, Mariano Esteban
Published 2011-01-01

Deletion of Vaccinia Virus A40R Gene Improves the Immunogenicity of the HIV-1 Vaccine Candidate MVA-B

by Patricia Pérez, María Q. Marín, Adrián Lázaro-Frías, Carlos Óscar S. Sorzano, Carmen E. Gómez, Mariano Esteban, Juan García-Arriaza
Published 2020-02-01

Potent HIV-1-Specific CD8 T Cell Responses Induced in Mice after Priming with a Multiepitopic DNA-TMEP and Boosting with the HIV Vaccine MVA-B

by Beatriz Perdiguero, Suresh C. Raman, Cristina Sánchez-Corzo, Carlos Oscar S. Sorzano, José Ramón Valverde, Mariano Esteban, Carmen Elena Gómez
Published 2018-08-01

A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.

by Juan García-Arriaza, José Luis Nájera, Carmen E Gómez, Nolawit Tewabe, Carlos Oscar S Sorzano, Thierry Calandra, Thierry Roger, Mariano Esteban
Published 2011-01-01

Deletion of the vaccinia virus gene A46R, encoding for an inhibitor of TLR signalling, is an effective approach to enhance the immunogenicity in mice of the HIV/AIDS vaccine candid...

by Beatriz Perdiguero, Carmen Elena Gómez, Mauro Di Pilato, Carlos Oscar S Sorzano, Julie Delaloye, Thierry Roger, Thierry Calandra, Giuseppe Pantaleo, Mariano Esteban
Published 2013-01-01

FSC-Q: a CryoEM map-to-atomic model quality validation based on the local Fourier shell correlation

by Erney Ramírez-Aportela, David Maluenda, Yunior C. Fonseca, Pablo Conesa, Roberto Marabini, J. Bernard Heymann, Jose Maria Carazo, Carlos Oscar S. Sorzano
Published 2021-01-01